Search Results - clinical+and+disease+specializations+%3e+pain

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Cell-Permeable Protein Therapeutic for Pain and Itch

Novelty:Identification of a mutant peptide with strong inhibitory effect on nociceptor TRPA1, useful for the prevention and treatment of chronic and acute pain and itch.Value Proposition:Dysregulation of ion channels is associated with various debilitating conditions, including chronic pain and itch. Transient receptor potential ankyrin 1 (TRPA1), an...

Published: 5/9/2024 | Inventor(s): Hao-Jui Weng, Xinzhong Dong

Keywords(s): Biologics, Biomarker, Chronic Pain, CNS and Neurological Disorders, Disease Indication, Mechanism of Action Biomarker, Peptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Pain, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Pain > Chronic Pain

Polymeric Vaccine for Opioid Addiction

Value Proposition:· Elicits production of anti-Fentanyl antibodies· Leads to long-lasting anti-opioid responses without toxicity· Exhibits 1000-fold increase in antibody production over conventional drug vaccines Technology DescriptionResearchers at Johns Hopkins have developed a polymeric fentanyl vaccine. Upon a primary injection and...

Published: 5/10/2024 | Inventor(s): David Wilson, Sandeep Kumar

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Vaccines, Clinical and Disease Specializations > Pain, Clinical and Disease Specializations > Psychiatry > Addiction

Opioid Antagonists for Use in Patients Using Chimeric Antigen Receptor T and NK Cell Therapy

Unmet NeedCancer patients often experience extreme, chronic pain that is addressed through prescription opioids. These opioids can block receptors on NK and T cells, resulting in a reduced ability to initiate apoptosis and therefore a reduced immune response. This, combined with other factors including the cancer itself, chemotherapy and radiation treatments...

Published: 5/10/2024 | Inventor(s): Dermot Maher, Nicola Heller

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Pain, Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Therapeutic Modalities > Gene Therapies

Pain Rounds

Unmet NeedThe U.S. Department of Health and Human Services (HHS) recently recognized the trend of “inadequately trained clinicians” performing interventional pain procedures as a contributor to “serious complications and inappropriate utilization.” Historically fellowships accredited by the Accreditation Council for Graduate Medical Education (ACGME)...

Published: 5/10/2024 | Inventor(s): Shravani Durbhakula

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Category(s): Technology Classifications > Computers, Electronics & Software > Education Tech, Clinical and Disease Specializations > Pain, Clinical and Disease Specializations > Neurology

C13683 - Anti-Tmem100 Antibody

Invention Novelty: The Johns Hopkins researchers have developed rabbit polyclonal antibody specifically against Tmem100 that is suitable is suitable for immunohistochemical staining of tissue sections and western blot to detect Tmem100 protein level. Value Proposition: Tmem100 is a 134-amino acid, two-transmembrane protein highly conserved in vertebrates...

Published: 5/9/2024 | Inventor(s): Xinzhong Dong

Keywords(s): Antibodies, Chronic Pain, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Polyclonal Antibodies, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Research Tools > Antibodies, Clinical and Disease Specializations > Pain, Technology Classifications > Research Tools

Buccal and Intranasal Delivery of Fospropofol

INVENTION NOVELTY This invention provides for novel formulations and delivery methods of the propofol prodrug, fospropofol, allowing for its use in additional indications beyond anesthesia, including migraine, analgesia, and emesis treatment. VALUE PROPOSITION Propofol and its water soluble prodrug, fospropofol, are short-acting anesthetics used...

Published: 5/9/2024 | Inventor(s): Barbara Slusher, Rana Rais, James Vornov

Keywords(s): Chronic Pain, CNS and Neurological Disorders, Disease Indication, Migraine, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Migraine, Clinical and Disease Specializations > Pain, Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

A High Throughput Screen Utilizing Newly Discovered Intramolecular Neuronal Calcium Channel interactions to Discover New Analgesics

Unmet NeedChronic pain management continues to be a medical and public health imperative. N-type calcium channel blockers, such as FDA approved Prialt® (ziconotide), have been found to have analgesic effects (blocking pain signals from the nerves to the brain) and to work synergistically with opioids. Unfortunately, drugs like Prialt have serious adverse...

Published: 5/9/2024 | Inventor(s): Heather Agler, David Yue

Keywords(s): Basic Research Biomarker, Cell Model, Chronic Pain, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Neurons, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Pain