Search Results - clinical+and+disease+specializations+%3e+pain+%3e+chronic+pain

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Care Planning Forms -- Guided Care, 2022

Unmet Need There is a growing number of aging Americans living with multiple morbidities, which has placed immense financial burden on healthcare programs across the country (CMS, 2012). Under the current model, older adult patients seek general medical care from their primary care physician (PCP), and additionally visit specialists for specific...

Published: 5/10/2024 | Inventor(s): Charles (Chad) Boult

Keywords(s):

Category(s): Copyright, Clinical and Disease Specializations > Pain > Chronic Pain

Cell-Permeable Protein Therapeutic for Pain and Itch

Novelty:Identification of a mutant peptide with strong inhibitory effect on nociceptor TRPA1, useful for the prevention and treatment of chronic and acute pain and itch.Value Proposition:Dysregulation of ion channels is associated with various debilitating conditions, including chronic pain and itch. Transient receptor potential ankyrin 1 (TRPA1), an...

Published: 5/9/2024 | Inventor(s): Hao-Jui Weng, Xinzhong Dong

Keywords(s): Biologics, Biomarker, Chronic Pain, CNS and Neurological Disorders, Disease Indication, Mechanism of Action Biomarker, Peptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Pain, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Pain > Chronic Pain

Closed-loop Peripheral Nerve Stimulation for Restoration in Chronic Pain

Unmet NeedChronic pain affects about 100-million adults in the United States and is primarily treated with drugs, which can have significant negative side effects (NIH-Institute of Medicine). A promising alternative therapy is electrical peripheral nerve stimulation (PNS) therapy. However, PNS therapy has been associated with suboptimal efficacy because...

Published: 5/10/2024 | Inventor(s): Sridevi Sarma, Christine Beauchene, Yun Guan, Claire Zurn

Keywords(s):

Category(s): Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices > Therapeutic Devices

Opioid Antagonists for Use in Patients Using Chimeric Antigen Receptor T and NK Cell Therapy

Unmet NeedCancer patients often experience extreme, chronic pain that is addressed through prescription opioids. These opioids can block receptors on NK and T cells, resulting in a reduced ability to initiate apoptosis and therefore a reduced immune response. This, combined with other factors including the cancer itself, chemotherapy and radiation treatments...

Published: 5/10/2024 | Inventor(s): Dermot Maher, Nicola Heller

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Pain, Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Therapeutic Modalities > Gene Therapies

C13683 - Anti-Tmem100 Antibody

Invention Novelty: The Johns Hopkins researchers have developed rabbit polyclonal antibody specifically against Tmem100 that is suitable is suitable for immunohistochemical staining of tissue sections and western blot to detect Tmem100 protein level. Value Proposition: Tmem100 is a 134-amino acid, two-transmembrane protein highly conserved in vertebrates...

Published: 5/9/2024 | Inventor(s): Xinzhong Dong

Keywords(s): Antibodies, Chronic Pain, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Polyclonal Antibodies, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Research Tools > Antibodies, Clinical and Disease Specializations > Pain, Technology Classifications > Research Tools

Buccal and Intranasal Delivery of Fospropofol

INVENTION NOVELTY This invention provides for novel formulations and delivery methods of the propofol prodrug, fospropofol, allowing for its use in additional indications beyond anesthesia, including migraine, analgesia, and emesis treatment. VALUE PROPOSITION Propofol and its water soluble prodrug, fospropofol, are short-acting anesthetics used...

Published: 5/9/2024 | Inventor(s): Barbara Slusher, Rana Rais, James Vornov

Keywords(s): Chronic Pain, CNS and Neurological Disorders, Disease Indication, Migraine, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Migraine, Clinical and Disease Specializations > Pain, Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

A High Throughput Screen Utilizing Newly Discovered Intramolecular Neuronal Calcium Channel interactions to Discover New Analgesics

Unmet NeedChronic pain management continues to be a medical and public health imperative. N-type calcium channel blockers, such as FDA approved Prialt® (ziconotide), have been found to have analgesic effects (blocking pain signals from the nerves to the brain) and to work synergistically with opioids. Unfortunately, drugs like Prialt have serious adverse...

Published: 5/9/2024 | Inventor(s): Heather Agler, David Yue

Keywords(s): Basic Research Biomarker, Cell Model, Chronic Pain, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Neurons, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Pain