Search Results - chronic+pain

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Cell-Permeable Protein Therapeutic for Pain and Itch

Novelty:Identification of a mutant peptide with strong inhibitory effect on nociceptor TRPA1, useful for the prevention and treatment of chronic and acute pain and itch.Value Proposition:Dysregulation of ion channels is associated with various debilitating conditions, including chronic pain and itch. Transient receptor potential ankyrin 1 (TRPA1), an...

Published: 5/9/2024 | Inventor(s): Hao-Jui Weng, Xinzhong Dong

Keywords(s): Biologics, Biomarker, Chronic Pain, CNS and Neurological Disorders, Disease Indication, Mechanism of Action Biomarker, Peptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Pain, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Pain > Chronic Pain

C13683 - Anti-Tmem100 Antibody

Invention Novelty: The Johns Hopkins researchers have developed rabbit polyclonal antibody specifically against Tmem100 that is suitable is suitable for immunohistochemical staining of tissue sections and western blot to detect Tmem100 protein level. Value Proposition: Tmem100 is a 134-amino acid, two-transmembrane protein highly conserved in vertebrates...

Published: 5/9/2024 | Inventor(s): Xinzhong Dong

Keywords(s): Antibodies, Chronic Pain, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Polyclonal Antibodies, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Research Tools > Antibodies, Clinical and Disease Specializations > Pain, Technology Classifications > Research Tools

C13783 - Pirt-Cre Mice

Invention novelty: JHU researchers have generated generated Pirt-Cre mice in which Cre recombinase is expressed specifically in all primary sensory neurons in dorsal root ganglion (DRG) under the control of Pirt promoter. Value Proposition:Primary sensory neurons in dorsal root ganglion (DRG) play essential role in initiating, transmitting, and modulating...

Published: 5/9/2024 | Inventor(s): Xinzhong Dong

Keywords(s): Basic Research Biomarker, Chronic Pain, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Itch, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Itch

Buccal and Intranasal Delivery of Fospropofol

INVENTION NOVELTY This invention provides for novel formulations and delivery methods of the propofol prodrug, fospropofol, allowing for its use in additional indications beyond anesthesia, including migraine, analgesia, and emesis treatment. VALUE PROPOSITION Propofol and its water soluble prodrug, fospropofol, are short-acting anesthetics used...

Published: 5/9/2024 | Inventor(s): Barbara Slusher, Rana Rais, James Vornov

Keywords(s): Chronic Pain, CNS and Neurological Disorders, Disease Indication, Migraine, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Migraine, Clinical and Disease Specializations > Pain, Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

A High Throughput Screen Utilizing Newly Discovered Intramolecular Neuronal Calcium Channel interactions to Discover New Analgesics

Unmet NeedChronic pain management continues to be a medical and public health imperative. N-type calcium channel blockers, such as FDA approved Prialt® (ziconotide), have been found to have analgesic effects (blocking pain signals from the nerves to the brain) and to work synergistically with opioids. Unfortunately, drugs like Prialt have serious adverse...

Published: 5/9/2024 | Inventor(s): Heather Agler, David Yue

Keywords(s): Basic Research Biomarker, Cell Model, Chronic Pain, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Neurons, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Pain