Search Results - xinzhong+dong

6 Results

Sort By:

Cell-Permeable Protein Therapeutic for Pain and Itch

Novelty:Identification of a mutant peptide with strong inhibitory effect on nociceptor TRPA1, useful for the prevention and treatment of chronic and acute pain and itch.Value Proposition:Dysregulation of ion channels is associated with various debilitating conditions, including chronic pain and itch. Transient receptor potential ankyrin 1 (TRPA1), an...

Published: 5/9/2024 | Inventor(s): Hao-Jui Weng, Xinzhong Dong

Keywords(s): Biologics, Biomarker, Chronic Pain, CNS and Neurological Disorders, Disease Indication, Mechanism of Action Biomarker, Peptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Pain, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Pain > Chronic Pain

C13683 - Anti-Tmem100 Antibody

Invention Novelty: The Johns Hopkins researchers have developed rabbit polyclonal antibody specifically against Tmem100 that is suitable is suitable for immunohistochemical staining of tissue sections and western blot to detect Tmem100 protein level. Value Proposition: Tmem100 is a 134-amino acid, two-transmembrane protein highly conserved in vertebrates...

Published: 5/9/2024 | Inventor(s): Xinzhong Dong

Keywords(s): Antibodies, Chronic Pain, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Polyclonal Antibodies, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Research Tools > Antibodies, Clinical and Disease Specializations > Pain, Technology Classifications > Research Tools

C13783 - Pirt-Cre Mice

Invention novelty: JHU researchers have generated generated Pirt-Cre mice in which Cre recombinase is expressed specifically in all primary sensory neurons in dorsal root ganglion (DRG) under the control of Pirt promoter. Value Proposition:Primary sensory neurons in dorsal root ganglion (DRG) play essential role in initiating, transmitting, and modulating...

Published: 5/9/2024 | Inventor(s): Xinzhong Dong

Keywords(s): Basic Research Biomarker, Chronic Pain, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Itch, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Itch

Pirt-GCaMP3 Mice

Invention novelty: Primary sensory neurons in the DRG play essential role in initiating somatosensory such as pain, itch, and touch by directly sensing various sensory stimuli like mechanical, chemical, and thermal stimuli. Dysfunction of these neurons often leads to various pathological conditions including chronic pain and itch. Currently, no one...

Published: 5/9/2024 | Inventor(s): Xinzhong Dong

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Itch, Knock In Mouse Model, Mouse Model, Neuropathy

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Itch, Clinical and Disease Specializations > Neurology > Neuropathy

Chloroquine-induced Itch is Mediated by Mrgs

C10519: Methods and Compositions for Treating Itch Value Proposition: Inventors have identified a cell receptor family known as Mrgprs that is exclusively expressed in a small subset of neurons. In vitro and animal studies suggest that the Mrg receptor family directly mediates chloroquine (CQ) induced itch. Identification and characterization of Mrgprs...

Published: 5/9/2024 | Inventor(s): David Anderson, Qin Liu, Xinzhong Dong

Keywords(s): Biomarker, CNS and Neurological Disorders, Disease Indication, Infectious Diseases, Inflammatory Disorders, Itch, Malaria, Mechanism of Action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Inflammation, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Neurology > Itch

C10396 - Rabbit Polyclonal Anti-Pirt Antibody.

Description:Polyclonal antibody that recognizes (Pirt) protein. Technical Overview:Transient receptor potential vanilloid 1 (TRPV1) is a molecular sensor of pain. Its channel activity can be modulated by several mechanisms. JHU researchers describe a membrane protein, called phosphoinositide interacting regulator of TRP (Pirt), which is expressed specifically...

Published: 5/9/2024 | Inventor(s): Xinzhong Dong

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Proteomics/Immunoassays, Proteomics/Immunoassays Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools