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Artifact Control and Miniaturization of the Safe DC Stimulator for Neural Prostheses
Safe DC Stimulator for Neural ProsthesesJHU Ref #: [C11822] Unmet NeedCurrently, neural prostheses are limited because they excite neurons but cannot efficiently inhibit them. Direct current (DC) can excite, inhibit, or control extracellular potential of target neurons, but DC stimulation is biologically unsafe. The current solution is to direct DC...
Published: 5/9/2024   |   Inventor(s): Charles Della Santina, Gene Fridman
Keywords(s): CNS and Neurological Disorders, Disease Indication, Neuroprosthetic Sensing Algorithms, Neuroprosthetics, Prosthetics, Therapeutic Devices, Therapeutics
Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices > Prosthetics, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Therapeutic Devices
Machine Learning Optimization for a Neural Implant
Unmet NeedElectrical stimulation with neural implants plays a crucial role in restoring sensory and motor function, as well as treating neurological disorders, including Parkinson’s disease[i], seizures, and even psychiatric disorders. Despite decades of research and development, neural implants only result in limited restoration of function in patients...
Published: 5/10/2024   |   Inventor(s): Gene Fridman, Cynthia Steinhardt
Keywords(s):  
Category(s): Copyright, Technology Classifications > Medical Devices > Neurostimulation
Interferential Current Stimulator for Peripheral Nerves
Technology Description·        Researchers at Johns Hopkins have developed a small, wireless, implantable device for the treatment of neurologic disorders (e.g., epilepsy, Parkinsons).·        This device includes only the minimum circuitry required for stimulation, reducing negative side effects associated with standard tethered cuff electrodes.·        The...
Published: 5/15/2024   |   Inventor(s): Ryan Budde, Pedro Irazoqui, Michael Williams
Keywords(s):  
Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Epilepsy, Technology Classifications, Technology Classifications > Medical Devices > Neurostimulation
Closed-loop Peripheral Nerve Stimulation for Restoration in Chronic Pain
Unmet NeedChronic pain affects about 100-million adults in the United States and is primarily treated with drugs, which can have significant negative side effects (NIH-Institute of Medicine). A promising alternative therapy is electrical peripheral nerve stimulation (PNS) therapy. However, PNS therapy has been associated with suboptimal efficacy because...
Published: 5/10/2024   |   Inventor(s): Sridevi Sarma, Christine Beauchene, Yun Guan, Claire Zurn
Keywords(s):  
Category(s): Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices > Therapeutic Devices
Neural Stimulation Alters Native Sensory Perception
Unmet NeedElectrical stimulation to the brain is a new emerging field of research with great potential. As neurons within the brain communicate through electrical charges, the ability to manipulate the delivery of such electrical charges through a stimulation machine may be beneficial for neuro-rehabilitation. Examples of such efforts already underway...
Published: 5/10/2024   |   Inventor(s): Pablo Celnik, Gabriela Cantarero, Ambarish Pawar, David McMullen, Robert Chmielewski, Margaret Thompson, Francesco Tenore, Breanne Christie, Luke Osborn, Matthew Fifer
Keywords(s):  
Category(s): Technology Classifications > Medical Devices > Neurostimulation, Clinical and Disease Specializations > Neurology
Safe Direct Current Stimulator Design for Reduced Power and Increased Reliability
Unmet NeedNeuroprostheses, such as cochlear implants and neural pacemakers, have already been proven to be useful in varying applications. Current neuroprostheses tools typically employ biphasic pulsatile stimulation, a process where electrodes have both a cathodic phase and an anodic phase to pass charge in both directions. Direct current (DC) has...
Published: 5/9/2024   |   Inventor(s): Gene Fridman
Keywords(s): CNS and Neurological Disorders, Computer and Network Systems, Computer Hardware, Disease Indication, Implanted Device, Implants, Neuromodulator, Therapeutic Devices, Therapeutics
Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices
Nerve-sparing Surgical Guidance Using Neuromodulation-based Nerve Localization
Unmet NeedGlobally, prostate cancer is the second leading cause of cancer and the sixth leading cause of cancer-related death in men.  In the U.S., prostate cancer is the most common and diagnosed cancer in males. It is estimated there are 2.5 million men living with prostate cancer in the US, and the number is on the rise. The survival of prostate...
Published: 5/9/2024   |   Inventor(s): Emad Boctor, Jeeun Kang, Arthur Burnett, Jin Kang, Maged Harraz
Keywords(s): Disease Indication, Erectile Dysfunction (ED), Imaging and Sensing Systems, Imaging Modality, Implanted Device, Implants, In Vivo Medical Imaging, Integrated Imaging System, Integrated Robotic and Imaging System, Interventional and Surgical Systems, Men's Health, Neuromodulator, Surgical Navigation, Therapeutic Devices, Therapeutics, Ultrasound (US)
Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices > Surgical, Clinical and Disease Specializations > Men's Health
Initial Proof-of-Concept of Photoacoustic Neural Stimulation; A Potential Approach to Retinal Stimulation: Preliminary In Vitro Study
Unmet NeedNon-cataract related vision loss affects 22.9 million people worldwide. Many of these patients retain partial functionality in their retinas; even though their outer retinas no longer function, visual stimulation can be achieved by sending messages from the inner retinas through the optic nerves. Present efforts to restore vision to these...
Published: 5/9/2024   |   Inventor(s): Emad Boctor, James Spicer, Peter Gehlbach, Jeeun Kang, Maged Harraz
Keywords(s): Disease Indication, Environmental Sensing, Eye Disorders, Imaging and Sensing Systems, Implanted Device, Implants, Neuromodulator, Photodetector, Sensors, Signal Display Software, Therapeutic Devices, Therapeutics
Category(s): Technology Classifications > Computers, Electronics & Software > Sensors, Technology Classifications > Industrial Tech > Energy, Infrastructure & Environment, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Industrial Tech, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices > Neurostimulation
System and Method for Phase Dependent Brain Neuromodulation
Unmet Need                 Neuromodulation is a technology that involves the spatiotemporal alteration of brain activity with electrical, magnetic, or chemical stimulation. Neuromodulation devices can be implantable or non-implantable and target specific areas of the body in order to restore proper activity to a malfunctioning nervous system most commonly...
Published: 5/9/2024   |   Inventor(s): William Anderson, Yousef Salimpour, Leon Chen, Kelly Mills
Keywords(s): Brain Stimulation, CNS and Neurological Disorders, Disease Indication, Implanted Device, Implants, Interventional and Surgical Systems, Neuromodulator, Surgical Intervention Method, Therapeutic Devices, Therapeutics
Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices
Particulate Drug Delivery System to Enable Targeted Ultrasound-gated Release of Neuromodulatory Agents
Targeted, noninvasive neuromodulation of the brain of an otherwise awake subject could revolutionize both basic and clinical neuroscience. Towards this goal, the JHU scientists have developed nanoparticles that allow noninvasive uncaging of a neuromodulatory drug upon the application of focused ultrasound. These nanoparticles are composed of biodegradable...
Published: 5/9/2024   |   Inventor(s): Jordan Green, Raag Airan, Randall Meyer
Keywords(s): CNS and Neurological Disorders, Disease Indication, Drug Delivery Mechanism, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Nerve Disorders and Injury, Therapeutic Matter, Therapeutics
Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices > Neurostimulation
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