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A DNA Vaccine for Eliciting T Cell Immunity in the Lung

Unmet NeedRespiratory pathogens are a major contributor to global economic and public health crises. In the wake of the COVID-19 pandemic, new vaccine technologies have been developed to improve the response to emerging pathogens. However, questions remain regarding how to deal with pathogens that have the potential to cause future pandemics. New vaccination...

Published: 5/10/2024 | Inventor(s): Richard Markham, James Gordy, Petros Karakousis

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Covid-19, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Technology Classifications > Therapeutic Modalities > Vaccines

Polymeric Vaccine for Opioid Addiction

Value Proposition:· Elicits production of anti-Fentanyl antibodies· Leads to long-lasting anti-opioid responses without toxicity· Exhibits 1000-fold increase in antibody production over conventional drug vaccines Technology DescriptionResearchers at Johns Hopkins have developed a polymeric fentanyl vaccine. Upon a primary injection and...

Published: 5/10/2024 | Inventor(s): David Wilson, Sandeep Kumar

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Vaccines, Clinical and Disease Specializations > Pain, Clinical and Disease Specializations > Psychiatry > Addiction

Polymeric Nanoparticle Genetic Vaccines

Value PropositionVersatile immunotherapy platform with the ability to specifically target antigen presenting cells (APCs) ) following systemic delivery and without requiring targeting ligands to improve treatment efficacy. Flexibility to modulate the immune system through activation or inducing tolerance.Useful as a preventative strategy or therapeutic...

Published: 5/10/2024 | Inventor(s): Jordan Green, Elana Ben-Akiva, Johan Karlsson, Stephany Tzeng, Kelly Rhodes, Sarah Neshat

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Immunology, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

Compositions and Methods of Increasing RNA Translation

Value Proposition mRNA use for therapeutic purposes has proven useful in treating a wide array of diseases. Major challenges of mRNA therapies include immunogenicity, poor expression, and low stability. This therapy contains modifications improving mRNA stability, efficiency, and immunogenicity. This technology allows for the translation of almost...

Published: 5/10/2024 | Inventor(s): Jeffery Coller, Zachary Mandell

Keywords(s):

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Vaccines

Peptide for the Prevention and Treatment of Coronavirus Infection

Value Proposition· Peptide-based supramolecular filament that attenuates SARS-CoV virus infectivity in vivo· Leverages ACE2 enzyme-substrate docking activity· Enables therapeutic protein delivery in repairable aerosolsUnmet Need· Respiratory illnesses, including tuberculosis, influenza, and COVID-19, pose a significant worldwide...

Published: 5/10/2024 | Inventor(s): Honggang Cui, Hongpeng Jia, Caleb Anderson

Keywords(s):

Category(s): Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

A T-cell Vaccine for SARS Virus

Unmet Need· In response to the global COVID-19 pandemic, a variety of vaccines have been rapidly developed to prevent serious illness or death from infection by SARS-CoV-2. The gold standard are mRNA vaccines which deliver mRNA to make copies of the SARS-CoV-2 spike protein, which ultimately activates immunes cells to produce antibodies against...

Published: 5/10/2024 | Inventor(s): Maxim Rosario, Bette Korber

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Vaccines

Reprogramming Aluminum Adjuvants to Tailor Immune Response

Unmet NeedVaccination is an important public health intervention that has led to the rapid decline of many infectious diseases. To maximize safety and minimize reactogenicity, vaccine development is gradually shifting from whole, inactivated vaccines to well defined subunit vaccines. However, this approach often suffers from reduced immunogenicity....

Published: 5/10/2024 | Inventor(s): Hai-Quan Mao, Gregory Howard

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Immunology, Technology Classifications > Therapeutic Modalities > Vaccines

Method to Enhance Pulmonary Dendritic Cell-mediated DNA Vaccination

Unmet NeedWith lung diseases, namely influenza and lung cancer, on the rise, pulmonary vaccination is a promising approach to elicit strong immunity to inhaled pathogens and lung cancer compared to systemic immunization strategies. In particular, inhaled DNA vaccination, a rapidly developing field, can potentially promote humoral and cellular immunity...

Published: 5/9/2024 | Inventor(s): Jung Soo Suk, Yoo Chun Kim, Justin Hanes

Keywords(s): Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Immunotherapy, Infectious Diseases, Influenza, Lung Cancer, Nanoparticles, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Tuberculosis (TB), Vaccine

Category(s): Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Clinical and Disease Specializations > Infectious Diseases > Influenza, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology > Lung Cancer, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

A DNAJB1-PRKACA fusion kinase peptide vaccine for patients with fibrolamellar hepatocellular carcinoma

Unmet NeedFibrolamellar carcinoma (FLC) is an extremely rare form of cancer. It affects both men and women in approximately 1 in 5,000,000 people with greater frequency among young adults with a median age of diagnosis of 25. Unfortunately, there is no standard of care therapy for this cancer, and patients with this disease have an expected median survival...

Published: 5/10/2024 | Inventor(s): Mark Yarchoan, Elizabeth Jaffee, Aditya Mohan

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Liver Cancer, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Therapeutic Modalities > Immunotherapies

Multi-epitope Fusion Antigen Vaccine for ETEC

Unmet Need: Enterotoxigenic Escherichia coli (ETEC) is the leading cause of diarrheal diseases worldwide but to date no effective vaccine exists due to the heterogeneity in ETEC strains. There is a need for a vaccine that elicits a broad yet productive immune response against multiple ETEC antigens to provide protection. Technical Details: Researchers...

Published: 5/9/2024 | Inventor(s): Weiping Zhang, David Sack

Keywords(s): Biologics, Disease Indication, Drug Delivery Mechanism, Immunotherapy, Infectious Diseases, Oral Administration, Protein, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Vaccine

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

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