Search Results - justin+hanes

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Methods and Compositions for Achieving Sustained Intraocular Drug Delivery via Melanin Binding

Unmet Need / Invention Novelty: Intravitreal injection is the gold standard for achieving drug delivery to the posterior segment of the eye. However, achieving effective delivery is challenging and the injections need to be performed frequently which hinders patient compliance. There therefore exists an unmet need to develop a formulation for intraocular...

Published: 5/10/2024 | Inventor(s): Laura Ensign-Hodges, Justin Hanes, Yoo Chun Kim, Tung Heng Hsueh

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Ophthalmology

Compositions and methods for controlled release suprachoroidal drug delivery

Unmet Need / Invention Novelty: Traditional routes of administrating drugs to the eye are limited by lack of efficiency, frequent side effects, and poor patient tolerance of repeated injections into the eye. Injections into the suprachoroidal space (SCS) is an attractive strategy to overcome these limitations and to provide for targeted delivery of...

Published: 5/9/2024 | Inventor(s): Laura Ensign-Hodges, Peter Campochiaro, Justin Hanes, Yoo Chun Kim, Jikui Shen, Jie Fu

Keywords(s): Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Eye Disorders, Hydrogel, Local Ocular, Microspheres, Polymers, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Method for Cervicovaginal Secretion Transplants to Restore Healthy Vaginal Microbiota

Approximately one-third of all women currently have bacterial vaginosis (BV), a condition where the vaginal microbiota is not dominated by lactobacilli. Another one-third of women have mixed vaginal microbiota (intermediate BV), and only one-third of women have healthy, lactobacilli-dominated microbiota. Women with BV are known to have >2-6-fold...

Published: 5/9/2024 | Inventor(s): Justin Hanes, Richard Cone, Laura Ensign-Hodges

Keywords(s): Biologics, Disease Indication, Therapeutic Matter, Therapeutic Substance, Therapeutics, Transplant, Transplants, Women's Health

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Transplantation, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Microbiome, Clinical and Disease Specializations > Women's Health, Technology Classifications > Therapeutic Modalities

Method to Enhance Pulmonary Dendritic Cell-mediated DNA Vaccination

Unmet NeedWith lung diseases, namely influenza and lung cancer, on the rise, pulmonary vaccination is a promising approach to elicit strong immunity to inhaled pathogens and lung cancer compared to systemic immunization strategies. In particular, inhaled DNA vaccination, a rapidly developing field, can potentially promote humoral and cellular immunity...

Published: 5/9/2024 | Inventor(s): Jung Soo Suk, Yoo Chun Kim, Justin Hanes

Keywords(s): Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Immunotherapy, Infectious Diseases, Influenza, Lung Cancer, Nanoparticles, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Tuberculosis (TB), Vaccine

Category(s): Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Clinical and Disease Specializations > Infectious Diseases > Influenza, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology > Lung Cancer, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

Entirely GRAS Material-based Large Brain-Penetrating Nanoparticles for Widespread Therapeutic Distribution in Healthy and Tumor-bearing Brain Tissues

Unmet NeedGlioblastomas account for 45% of all brain cancers, and affect nearly 11,000 men, women and children every year. They are the most debilitating, complex, and treatment-resistant brain tumors. They can become widespread quickly and can grow in multiple areas at once making them difficult to remove completely using surgery or radiation therapy....

Published: 5/9/2024 | Inventor(s): Jung Soo Suk, Karina Negron, Justin Hanes

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Gene Therapies, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Methods to achieve enhanced delivery to the bladder

Unmet Need: Bladder cancer is a global disease, with 540,000 incident cases and 188,000 deaths in 2015 worldwide. In the United States 81,190 patients will be diagnosed in 2018 and 17,240 will die from their disease.(1) The first-line treatment of non-muscle-invasive bladder cancer (NMIBC) is the transurethral resection of bladder tumors (TURBT),...

Published: 5/9/2024 | Inventor(s): Laura Ensign-Hodges, Justin Hanes, Abhijit Date, Trinity Bivalacqua, Max Kates

Keywords(s): Bladder Cancer, Cancers, Chemotherapy, Disease Indication, Drug Delivery Vehicle, Nanoparticles, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Urology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Bladder Cancer

PEGylated Human Heavy Chain Ferritin Nanocages and Their Uses for Therapeutic and Diagnostic Delivery

Unmet Need:Localized delivery of chemotherapeutics to the lung via inhalation provides a straightforward method of directly targeting lung cancers. However, due to the presence of multiple delivery barriers, the effectiveness of the approach has been limited. Here, we disclose an invention of a novel inhalable drug delivery platform capable of...

Published: 5/9/2024 | Inventor(s): Justin Hanes, Jung Soo Suk, Xinglu Huang

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Lung Cancer, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Lung Cancer, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Method to Improve Brain Penetration of Nanoparticles

Unmet Need / Invention Novelty: Drug delivery to the brain is hindered by the brain’s wide perivascular space and protein-dense extracellular matrix, which limits diffusion of drugs from site of administration into the brain parenchyma. Methods are needed to improve the penetration of drugs into the brain parenchyma. Technical Details: Johns Hopkins...

Published: 5/9/2024 | Inventor(s): Clark Zhang, Panagiotis Mastorakos, Jung Soo Suk, Justin Hanes

Keywords(s): Convection Enhanced Delivery (CED), Drug Delivery Mechanism, Drug Delivery Vehicle, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Formulation Method and Use of Highly Stable Biodegradable Gene Vector Platforms Capable of Overcoming Various Biological Barriers

JHU researchers have formulated compact, colloidally stable gene carriers that have a dense surface coverage of hydrophilic and neutrally charged PEG. These gene vectors stably retain their physicochemical characteristics over at least a week in aqueous solution and are highly stable in physiological solutions. Moreover, they demonstrate the ability...

Published: 5/9/2024 | Inventor(s): Panagiotis Mastorakos, Jung Soo Suk, Justin Hanes

Keywords(s): Biologics, Drug Delivery Vehicle, Gene Therapy, Nucleic Acid, Plasmid/Vector, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Engineering Synthetic Brain Penetrating Gene Vectors

Unmet Need:Gene delivery to the central nervous system (CNS) has potential as a means for treating numerous debilitating neurological diseases. Viral gene delivery, though relatively efficient, has been limited by immunogenicity, low packaging capacity and difficulties in manufacture and scale-up. Non-viral gene vectors offer an attractive alternate...

Published: 5/9/2024 | Inventor(s): Graeme Woodworth, Clark Zhang, Panagiotis Mastorakos, Jung Soo Suk, Justin Hanes

Keywords(s): Drug Delivery Vehicle Synthesis Method, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

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