Search Results - chemotherapy

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Methods to achieve enhanced delivery to the bladder

Unmet Need: Bladder cancer is a global disease, with 540,000 incident cases and 188,000 deaths in 2015 worldwide. In the United States 81,190 patients will be diagnosed in 2018 and 17,240 will die from their disease.(1) The first-line treatment of non-muscle-invasive bladder cancer (NMIBC) is the transurethral resection of bladder tumors (TURBT),...

Published: 5/9/2024 | Inventor(s): Laura Ensign-Hodges, Justin Hanes, Abhijit Date, Trinity Bivalacqua, Max Kates

Keywords(s): Bladder Cancer, Cancers, Chemotherapy, Disease Indication, Drug Delivery Vehicle, Nanoparticles, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Urology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Bladder Cancer

Membrane Active Chelators (MACs) as Chemotherapueutic Agents for Treatment of Human African Trypanosomiasis (HAT)

Membrane Activated Chelators (MACs) are proprietary neuroprotective drugs [D-PHARM LTD; Rehovot Isreal] that modulate cell membrane metal ion homeostasis by adopting an inactive conformation outside only in the lipid environment of cell membranes. In this environment, the drugs are able to unable to bind metal ions at their elevated non-physiological...

Published: 5/9/2024 | Inventor(s): Dennis Grab

Keywords(s): Antagonists/Inhibitors, Chemotherapy, Disease Indication, Human African Trypanosomiasis, Human African Trypanosomiasis (HAT), Infectious Diseases, Non-novel, Parasitic Infections, Predicted Novelty, Repurposed, Single, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Human African Trypanosomiasis, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

Therapies to Accelerate Resolution of Acute Lung Inflammation

Acute respiratory distress syndrome (ARDS) is a devastating inflammatory lung disease for which there are no effective targeted therapies. In experimental models of acute lung inflammation and injury, regulatory T cells (Tregs) orchestrate a pro-repair program; Tregs themselves are highly dependent on epigenetic mechanisms such as DNA hypomethylation. ...

Published: 5/9/2024 | Inventor(s): Franco D'alessio, Landon King, Benjamin Singer, Neil Aggarwal

Keywords(s): Acute Respiratory Distress Syndrome, Acute Respiratory Distress Syndrome (ARDS), Antagonists/Inhibitors, Chemotherapy, Disease Indication, Immunotherapy, Lung Disorders, Non-novel, Predicted Novelty, Repurposed, Single, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases > Acute Respiratory Distress Syndrome, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Repurposed Drugs

Self-Assembling Drug-Amphiphiles: A New Platform for the Delivery of Anticancer Chemotherapeutics

UNMET NEEDMany anticancer drug delivery systems suffer from lack of target specificity and drug-loading limitations. Additionally, many drug delivery systems require the use of a nanocarrier, which have certain disadvantages including limitations on the amount of loaded drug and batch to batch variability. This invention is a self-assembled drug-amphiphile...

Published: 5/9/2024 | Inventor(s): Andrew Cheetham, Pengcheng Zhang, Honggang Cui

Keywords(s): Cancers, Chemotherapy, Disease Indication, Drug Delivery Vehicle, Peptides/Prodrugs, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Novel Boronic Chalcone Derivatives and Uses Thereof

Technical Details: A class of anti-cancer agents such as chalcones has shown promising therapeutic efficacy for the management of human cancers. Recent studies have shown that anticancer agents such as chalcones induce apoptosis in variety of cell types, including breast cancers. Biochemical experiments showed that these compounds can disrupt the MDM2/p53...

Published: 5/9/2024 | Inventor(s): Saeed Khan

Keywords(s): Cancers, Chemotherapy, Disease Indication, Single, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

A p105-based NF-(kappa) B Super repressor

C04290: A p105-based NF-(kappa) B Super repressor Technical Details: Nuclear factor (NF)-kB is a family of transcription factors that regulate immune and inflammatory responses, programmed cell death (apoptosis), and developmental processes. In normal cells, NF-kB is latent, and is activated transiently by stimuli and stresses. However, under pathological...

Published: 5/9/2024 | Inventor(s): Li Lin

Keywords(s): Biologics, Cancers, Chemotherapy, Disease Indication, Nucleic Acid, Single, Skin Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities