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Nanoparticle Modification of Human Adipose-derived Mesenchymal Stem Cells for Brain Cancer and Other Neurological Diseases

Human Adipose-derived Mesenchymal Stem Cells can be engineered to synthesize and release anti-tumor proteins and therefore can be used as “Trojan Horses”. The inventors have created a novel technology which encompasses a solution containing biodegradable, polymeric nanoparticles that is combined with Freshly-extracted Adipose Tissue (F.A.T.) (from...

Published: 5/9/2024 | Inventor(s): Jordan Green, Alfredo Quinones-Hinojosa

Keywords(s): Biologics, Brain Cancer, Cancers, Cell Therapy, CNS and Neurological Disorders, Disease Indication, Drug Delivery Vehicle, Glioma, Nanoparticles, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Whole cell

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology > Glioma

Methods for Continuous Production of Uniform Polyelectrolyte Nanoparticles

Unmet NeedPolyelectrolyte nanoparticles have been widely used for various therapeutic delivery applications, from low molecular weight drugs to peptides and proteins. They are prepared by mixing oppositely charged polymers in aqueous media and are heterogeneous in terms of size and surface charge. However, current production methods rely on bulk mixing...

Published: 5/9/2024 | Inventor(s): Hai-Quan Mao, Jose Santos, Yong Ren, John-Michael Williford

Keywords(s): Drug Delivery Vehicle, Nanoparticles, Therapeutic Matter, Therapeutic Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Lipid Nanoparticles as Oral Vehicles of Immunotherapy

Unmet NeedType 1 diabetes (T1D) affects 1.25 million Americans currently and by 2050, this number is expected to reach 5 million. Though a currently untreatable autoimmune disease, one of the more promising approaches has been a costimulatory blockade of malfunctioning immune cells via administration of CTLA4-Ig. However, its efficacy is impeded by...

Published: 5/9/2024 | Inventor(s): Giorgio Raimondi, Julia Patrone, Xiomara Calderon-Colon, Olivia Tiburzi

Keywords(s): Diabetes, Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Immunotherapy, Metabolic Disorders, Nanoparticles, Oral Administration, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations > Diabetes > Type 1 Diabetes, Clinical and Disease Specializations > Diabetes, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Method to Enhance Pulmonary Dendritic Cell-mediated DNA Vaccination

Unmet NeedWith lung diseases, namely influenza and lung cancer, on the rise, pulmonary vaccination is a promising approach to elicit strong immunity to inhaled pathogens and lung cancer compared to systemic immunization strategies. In particular, inhaled DNA vaccination, a rapidly developing field, can potentially promote humoral and cellular immunity...

Published: 5/9/2024 | Inventor(s): Jung Soo Suk, Yoo Chun Kim, Justin Hanes

Keywords(s): Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Immunotherapy, Infectious Diseases, Influenza, Lung Cancer, Nanoparticles, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Tuberculosis (TB), Vaccine

Category(s): Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Clinical and Disease Specializations > Infectious Diseases > Influenza, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology > Lung Cancer, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

Compositions and Method for Production of Size-Controlled Ternary Nanoparticles for Sustained Release of Peptide Therapeutics

Unmet NeedType 2 diabetes (T2D) contributes to 90% of all cases of diabetes and represents a critical global public health problem. T2D specifically affects glucose metabolism and those with the disease either do not produce enough insulin or do not respond properly to insulin signaling to maintain normal levels of glucose in the blood. Several serious...

Published: 5/9/2024 | Inventor(s): Hai-Quan Mao, Zhiyu He, Yizong Hu, Yongming Chen, Lixin Liu

Keywords(s): Biologics, Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Peptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

Compositionally Defined Plasmid DNA/Polycation Nanoparticles and Methods for Making the Same

Unmet NeedGene therapy can be a cure-all for genetic disorders, and can be a promising therapy for diseases such as cancer, neurodegenerative diseases, neurological disorders, heart disease or diabetes. The success of gene therapy is dependent on the safety, efficacy, and specificity of the treatment. The delivery vehicle, also known as a vector, is...

Published: 5/9/2024 | Inventor(s): Hai-Quan Mao, Yizong Hu, Martin Pomper, Heng-wen Liu, Il Minn, Christopher Ullman, Christine Carrington

Keywords(s): Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Therapeutic Modalities > Gene Therapies, Clinical and Disease Specializations > Oncology

Adhesive/adsorption switch on nanoparticles to increase tumor uptake and delay tumor clearance

Unmet NeedEffective drug delivery to solid tumors remains challenging. Outcome failure rates can reach 90% for current therapeutic approaches for solid tumors. The use of nanoparticles for the delivery of therapeutic agents can enhance the safety, pharmacokinetic profile, and bioavailability of administered drugs, leading to improved therapeutic tolerance...

Published: 5/9/2024 | Inventor(s): Stavroula Sofou, Sarah Stras, Alaina Howe, Aprameya Ganesh Prasad, Dominick Salerno

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Compositions of nucleic acid-containing nanoparticles for in vivo delivery

Unmet NeedGene therapy has the potential to offer a one-time cure for severe, debilitating diseases that were previously untreatable or required chronic therapy. While a few viral-based gene therapies have recently received FDA approval, safety concerns around viral-based gene therapies continue to limit their clinical development. Non-viral strategies...

Published: 5/9/2024 | Inventor(s): Hai-Quan Mao, Il Minn, Yong Ren, Jose Santos, John-Michael Williford, Maani Archang, Martin Pomper

Keywords(s): Drug Delivery Vehicle, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Gene Delivery Particles to Induce Tumor-Derived Antigen Presenting Cells

Unmet Need Melanoma is an aggressive form of skin cancer that is characterized by high multidrug resistance and low survival rates. The median survival time for metastatic melanoma patients is approximately 8-9 months with a 3-year overall survival rate of less than 15%. As such, there is a compelling need for novel targeted melanoma therapies. Immunotherapy...

Published: 5/9/2024 | Inventor(s): Jordan Green, Stephany Tzeng, David Wilson, Randall Meyer

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Immunotherapies

Polymeric Nanoparticle Compositions for Encapsulation and Sustained Release of Protein Therapeutics and Methods for Scalable Production of the Same

Unmet NeedProtein therapeutics are used for a variety of medical treatments, such as cancer, infectious disease, hemophilia, anima, etc. The global market for protein drugs reached $174.7 billion in 2015. Therapeutic proteins support targeted therapeutic processes by compensating the deficiency of an essential protein. To successfully administer protein...

Published: 5/9/2024 | Inventor(s): Hai-Quan Mao, Sashank Reddy, Xiyu Ke, Chenhu Qiu, Daniel Lucena Domingues, Gregory Howard

Keywords(s): Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

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