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Compositions of Kinetic Nanoparticles containing Nucleic Acids, Polycations, and Lipids with Defined Sizes, and Methods of Producing the Same

Value Proposition:· Scalable, efficient, and tunable nanoparticle creation technique that can deliver a variety of payloads· Polymer-lipid nanoparticles are biodegradable and are being tested for immunogenicity· Can be used for in vivo gene therapy delivery as well as in vitro cell transfection and research applications Technology...

Published: 5/10/2024 | Inventor(s): Hai-Quan Mao, Stephany Tzeng, Jordan Green, Yizong Hu, Sashank Reddy, Leonardo Cheng

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Compositions of Lipid Nanoparticles for Plasmid DNA Delivery to the Liver and Methods for Preparing the Same

Value Proposition:· Library screen of lipid nanoparticles to develop compositions for efficient transfection and tissue-specific delivery.· Selected high efficiency lipid nanoparticles for delivering plasmid DNA, siRNA, and mRNA. Technology Description· Researchers at Johns Hopkins have developed a multi-step screening method to...

Published: 5/10/2024 | Inventor(s): Hai-Quan Mao, Yining Zhu, Sashank Reddy, Ruochen Shen, Ivan Vuong, Jingyao Ma, Leonardo Cheng

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Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Methods for Payload and Size Characterization of Nucleic Acid Nanoparticles

Polymeric and lipid nanoparticles (NPs) are an effective and safe method for therapeutic delivery. At each of the various steps in nanoparticle development and manufacturing (i.e., research and design, quality assurance), assessing the features of these vehicles is essential. Some features (i.e., packaging characteristics, cargo location, structure...

Published: 5/10/2024 | Inventor(s): Tza-Huei (Goes by Jeff) Wang, Hai-Quan Mao, Sixuan Li, Yizong Hu, Andrew Li

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Nucleic Acids

Nanoparticle Compositions for Sustained Delivery of Pro-regenerative Growth Factors for Nerve Repair, Preparation Processes of the Same, and Treatment Methods Using the Same

Unmet NeedGlobal incidence rates for peripheral nerve injury (PNI) are not well aggregated. However, US data collected shows that 20 million Americans suffer from peripheral nerve injury caused by trauma and medical disorders. [16] When a tension-free early repair is possible, microsurgical direct nerve repair with epineural sutures remains the gold...

Published: 5/10/2024 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Chenhu Qiu, Sashank Reddy, Yicheng Zhang, Thomas Harris, Philip Hanwright, Karim Sarhane, Nicholas von Guionneau, Erica Lee

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Category(s): Clinical and Disease Specializations > Wound Healing, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Reprogramming Aluminum Adjuvants to Tailor Immune Response

Unmet NeedVaccination is an important public health intervention that has led to the rapid decline of many infectious diseases. To maximize safety and minimize reactogenicity, vaccine development is gradually shifting from whole, inactivated vaccines to well defined subunit vaccines. However, this approach often suffers from reduced immunogenicity....

Published: 5/10/2024 | Inventor(s): Hai-Quan Mao, Gregory Howard

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Category(s): Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Immunology, Technology Classifications > Therapeutic Modalities > Vaccines

Composition of Shelf-stable Plasmid DNA/PEI Particles with Defined Sizes for Virus Production and Method for Preparation of the Same

Unmet NeedGene therapy has become increasingly popular for treating genetic and acquired diseases, with nearly 1000 ongoing clinical trials globally. These therapies are typically delivered via viral vectors, which are produced in vector production cell lines following transient transfection using nanoparticles such as those made of plasmid DNAs (pDNA)...

Published: 5/10/2024 | Inventor(s): Hai-Quan Mao, Yizong Hu, Yining Zhu

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Gene Therapies

Methods for Preparation of Shelf-stable Plasmid DNA/Polycation Particles with Defined Sizes for Cell Transfection

Published: 5/10/2024 | Inventor(s): Hai-Quan Mao, Yizong Hu, Yining Zhu

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Category(s): Technology Classifications > Therapeutic Modalities > Gene Therapies

Injectable macroporous composite for embolotherapy

Unmet NeedEmbolization as an interventional radiology practice is aimed at occluding or decreasing the blood or lymph flow through the endovascular application of different agents or materials. Therapeutic endovascular embolization can be used to treat acute and potentially fatal bleeds to aneurysms, vascular malformations, and for targeted oncologic...

Published: 5/9/2024 | Inventor(s): Hai-Quan Mao, Shin-Jae Lee, Siddharth Iyer, Mathias Insley, Xingyu Hu, Da In Lee, Christos Georgiades

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Category(s): Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Engineering Tech > Materials

Methods for Continuous Production of Uniform Polyelectrolyte Nanoparticles

Unmet NeedPolyelectrolyte nanoparticles have been widely used for various therapeutic delivery applications, from low molecular weight drugs to peptides and proteins. They are prepared by mixing oppositely charged polymers in aqueous media and are heterogeneous in terms of size and surface charge. However, current production methods rely on bulk mixing...

Published: 5/9/2024 | Inventor(s): Hai-Quan Mao, Jose Santos, Yong Ren, John-Michael Williford

Keywords(s): Drug Delivery Vehicle, Nanoparticles, Therapeutic Matter, Therapeutic Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Functional Fibers for Ex Vivo Expansion of Stem and Progenitor Cells

NeedUmbilical cord blood is a promising alternative source of hematopoietic stem/progenitor cells (HSPCs) for allogeneic and autologous hematopoietic stem cell transplantation for the treatment of a variety of hematological disorders and as supportive therapy for malignant diseases. However, the low number of HSPCs obtainable from a single donor restricts...

Published: 5/9/2024 | Inventor(s): Kam Leong, Kian-Ngiap Chua, Seeram Ramakrishna, Hai-Quan Mao

Keywords(s): Basic Research Biomarker, Cell Model, Discovery/Research Tools, In Vitro Research Tool, Stem Cells

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools

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