Search Results - clinical+and+disease+specializations+%3e+wound+healing

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Delayed Lagging Strand Synthesis Promotes Male Fertility during Aging

Value Proposition: · Induces stem cells from non-stem cells through modification of gene expression or function. · Relies on influencing a single DNA replication component rather than multiple molecular factors. · Successfully rescues both male and female fertility in Drosophila aging model. Technology...

Published: 5/17/2024 | Inventor(s): Xin Chen, Brendon Davis, Rajesh Ranjan

Keywords(s):

Category(s): Clinical and Disease Specializations > Reproductive Health > Fertility, Clinical and Disease Specializations > Wound Healing

Dextran Hydrogel Scaffolds Enhance Angiogenic Responses and Promote Complete Skin Regeneration During Burn Wound Healing

Unmet Need:Third-degree burns involve damage to both the epidermal and dermal layers and may also entail damage to underlying muscles, bones, and tendons. Such burns heal with thick scars, which result in contractures that distort the surrounding tissue. Deep third-degree burns usually require skin grafting to achieve wound closure, but the cosmetic...

Published: 5/9/2024 | Inventor(s): Guoming Sun, Xianjie Zhang, John Harmon, Sharon Gerecht

Keywords(s): Disease Indication, Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Nanoparticle Compositions for Sustained Delivery of Pro-regenerative Growth Factors for Nerve Repair, Preparation Processes of the Same, and Treatment Methods Using the Same

Unmet NeedGlobal incidence rates for peripheral nerve injury (PNI) are not well aggregated. However, US data collected shows that 20 million Americans suffer from peripheral nerve injury caused by trauma and medical disorders. [16] When a tension-free early repair is possible, microsurgical direct nerve repair with epineural sutures remains the gold...

Published: 5/10/2024 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Chenhu Qiu, Sashank Reddy, Yicheng Zhang, Thomas Harris, Philip Hanwright, Karim Sarhane, Nicholas von Guionneau, Erica Lee

Keywords(s):

Category(s): Clinical and Disease Specializations > Wound Healing, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Novel Gene Targets for Treatments Relating to Wound Healing, Immuno-oncology, and Fibrotic Disease

Unmet Need Hundreds of thousands of patients worldwide are affected by inflammatory diseases caused by a preexisting condition (inflammatory arthritis, psoriasis) or rejection of a foreign body (medical implant, open wounds). This is caused by the over/underexpression of certain phenotypes of macrophages within patients, yielding a disruption in homeostasis...

Published: 5/9/2024 | Inventor(s): Jennifer Elisseeff, Christopher Cherry, Sven Sommerfeld

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Wound Healing, Clinical and Disease Specializations > Fibrosis, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Targets

Multiphase Transitioning Peptride Hydrogel for Use in Vascular Anastamosis

Unmet NeedThe formation of vascular anastomosis, the joining of two blood vessels, is a fairly common procedure utilized by many surgeons. All vascular bypass operations and solid organ transplants require anastomoses. However, as the vessels being anastomosed become smaller or less firm, surgeons have exponentially increasing rates of failure. In...

Published: 5/9/2024 | Inventor(s): Daniel Smith, Johanna Grahammer, Joel Schneider, Gerald Brandacher, Gabriel Brat

Keywords(s): Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

Non-immunosuppressive FK506 analogs and use thereof

Unmet NeedChronic, nonhealing wounds are estimated to affect approximately 2% of the general population, and the cost of caring for these wounds exceeds $50 billion per year. These costs are expected to rise due to the increasing prevalence of diabetes and other diseases that hinder wound healing. Chronic infections increase morbidity and mortality...

Published: 5/9/2024 | Inventor(s): Jun Liu, Zhaoli Sun, Brandon Peiffer, Yuefan Wang, Le Qi, Zufeng Guo, Hanjing Peng, Ali Ahmadi

Keywords(s): Antagonists/Inhibitors, Combination, Disease Indication, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics, Therapy Type, Transplants

Category(s): Clinical and Disease Specializations > Wound Healing, Technology Classifications > Therapeutic Modalities > Small Molecules

Cancer in Angiogenesis

Unmet NeedIn the United States alone, almost 8.5 million people suffer from peripheral artery disease (PAD). The market for PAD and Peripheral Vascular Disease (PVD) is expected to reach $378.53 million with a CAGR of 7.06% by 2024. Therapeutic angiogenesis are therapies aimed at growing new vessels into compromised tissue. Wound healing, PAD, and coronary...

Published: 5/9/2024 | Inventor(s): Andrew Schulick

Keywords(s): Biologics, Cardiovascular Diseases, Cell Model, Coronary Heart Disease, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Peripheral Artery Disease, Stem Cells, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics, Whole cell, Wound Healing

Category(s): Technology Classifications > Therapeutic Modalities > Stem Cells, Clinical and Disease Specializations > Wound Healing, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Research Tools > Stem Cells

Wound Healing Compositions Comprising Biocompatible Cellulose Hydrogel Membranes and Methods of Use Thereof

Unmet NeedCorneal lacerations are a common type of eye injury. These can occur in varying degrees of severity, and in many cases the wound is non-self-sealing. This type of injury requires significant intervention including sutures and, in some cases, many layers of grafts. During the course of treatment patients are required to wear bandages that can...

Published: 5/9/2024 | Inventor(s): Jennifer Elisseeff, Daniel Mulreany, Qiongyu Guo, Morgana Trexler, Jennifer Breidenich, Jeffrey Maranchi, Iossif Strehin, Jemin Chae, Oliver Schein, Russel Mccally, Jenna Graham, Julia Patrone, Marcia Patchan, Xiomara Calderon-Colon

Keywords(s): Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Angiotensin Type 1 Receptor Autoantibody in Wound Healing

Unmet Need:Chronic wounds are among the most common, painful, debilitating and costly conditions in diabetics and in older adults, and are an important portal for bacterial infections that often lead to amputations, sepsis and mortality. In diabetic and aging skin, chronic inflammation commonly accompanies poor wound healing and increases the risk for...

Published: 5/9/2024 | Inventor(s): Peter Abadir, Jeremy Walston, Alka Jain, Neal Fedarko

Keywords(s): Biomarker, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Prognostic Biomarker, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Outgassing of Hyperbarically Loaded Polymeric Materials for Biomedical Applications

Unmet NeedTherapeutic gas delivery remains one of the greatest challenges in tissue engineering. Consequently many technologies and approaches have been developed but all lackeffective ways to deliver sufficient therapeutic gas, such as oxygen, to targeted regions within deeper tissue. This invention introduces a means of delivering therapeutic gases...

Published: 5/9/2024 | Inventor(s): Warren Grayson, Colin Cook

Keywords(s): Disease Indication, Drug Delivery Vehicle, Implantation Method, Implanted Device, Implants, Therapeutic Devices, Therapeutic Matter, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Wound Healing

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