Search Results - jennifer+elisseeff

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A Natural Anti-inflammatory Treatment to Reduce Corneal Scarring and Dry Eye

Unmet Need:According to the WHO, approximately 4.9 million people globally are affected by bacteria that leads to corneal scarring of the eye (WHO). Additionally, in the United States alone 4.88 million people age 50 and older suffer from dry eye, which may lead to scarring of the cornea (Healthline). The cornea serves as a window to the eye, and transparency...

Published: 5/10/2024 | Inventor(s): Jennifer Elisseeff, Liam Chung, Xiaokun Wang

Keywords(s):

Category(s): Clinical and Disease Specializations > Ophthalmology, Clinical and Disease Specializations > Ophthalmology > Dry Eye Syndrome, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Medical Devices > Regenerative Medicine

Hexosamine Analogs for Regenerative Medicine and Diseases Associated with the Musculoskeletal System

Unmet Need:Osteoarthritis (OA) is the most common form of arthritis, affecting an estimated 32.5 million adults in the United States, with an increasing incidence as the population ages (see CDC) . OA is associated with considerable morbidity as a consequence of joint damage, resulting in pain, loss of joint range of motion, and disability. The disease...

Published: 5/9/2024 | Inventor(s): Kevin Yarema, Jennifer Elisseeff, Jeannine Coburn, Udayanath Aich

Keywords(s): Antagonists/Inhibitors, Arthritis, Biologics, Carbohydrates, Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Joint Disorders, Novel, Osteoarthritis, Predicted Novelty, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Rheumatology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Rheumatology > Arthritis, Clinical and Disease Specializations > Rheumatology > Osteoarthritis

Novel Gene Targets for Treatments Relating to Wound Healing, Immuno-oncology, and Fibrotic Disease

Unmet Need Hundreds of thousands of patients worldwide are affected by inflammatory diseases caused by a preexisting condition (inflammatory arthritis, psoriasis) or rejection of a foreign body (medical implant, open wounds). This is caused by the over/underexpression of certain phenotypes of macrophages within patients, yielding a disruption in homeostasis...

Published: 5/9/2024 | Inventor(s): Jennifer Elisseeff, Christopher Cherry, Sven Sommerfeld

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Wound Healing, Clinical and Disease Specializations > Fibrosis, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Targets

Targeting Interleukin 17 and Senescent Cells for Treatment of the Foreign Body Response

Unmet Need13 million medical devices are implanted annually in the United States. Synthetic biomaterials are the building blocks of these implanted devices. Although biomaterials are selected for durability and minimal host immune response, all implanted biomaterials induce the foreign body response (FBR) to some degree, which creates a capsule of fibrous...

Published: 5/9/2024 | Inventor(s): Jennifer Elisseeff, Drew Pardoll, Franck Housseau, Liam Chung

Keywords(s): Antagonists/Inhibitors, Implants, Small Molecules, Target, Therapeutic Devices, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations > Traumatic Injury, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Medical Devices > Prosthetics

Cellulose-Based Hydrogels and Methods of Making Thereof

Unmet NeedHydrogels are water-insoluble polymers with the ability to swell without dissolution and to retain a large portion of solution within their structure. They have many uses, including contact lenses, wound dressings, tissue regenerative applications, orthopedic applications, drug delivery systems, sanitary napkins, cosmetic implants, and other...

Published: 5/9/2024 | Inventor(s): Julia Patrone, Morgana Trexler, Marcia Patchan, Xiomara Calderon-Colon, Jennifer Breidenich, Jeffrey Maranchi, Jennifer Elisseeff, Jenna Graham, Oliver Schein

Keywords(s): Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Extracellular Matrix Scaffolds for Combination Immunotherapy

Unmet NeedThe critically important goal of regenerative medicine is the stimulation of in vivo wound healing and the production of functional tissue to repair or replace tissues loss to injury or disease. Extracellular matrix (ECM) materials are acellular tissue derived scaffolds commonly used in tissue regeneration following malignant or benign tumor...

Published: 5/9/2024 | Inventor(s): Jennifer Elisseeff, Matthew Wolf

Keywords(s): Cancers, Cell Therapy/Immunotherapy, Combination, Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutic Matter, Therapeutics, Therapy Type, Tissue Engineering/Regenerative Devices

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Medical Devices > Regenerative Medicine

Cyclodextrin-incorporated Collagen Membrane for Biomedical Uses

Unmet NeedCorneal lacerations are a common type of eye injury. These can occur in varying degrees of severity, and in many cases the wound is non-self-sealing. This type of injury requires significant intervention including sutures and, in some cases, many layers of grafts. During the course of treatment patients are required to wear bandages that can...

Published: 5/9/2024 | Inventor(s): Jennifer Elisseeff, Qiongyu Guo, Shoumyo Majumdar

Keywords(s): Drug Delivery Device, Implanted Device, Implants, Prosthetic Device, Prosthetics, Therapeutic Devices, Therapeutics

Category(s): Technology Classifications > Medical Devices > Prosthetics, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices

Cornea Mimetic Biomaterials: Vitrified Collagen-cyclodextrin Implants

Unmet Need:Due to eye injuries and ocular diseases such as keratitis and keratoconus, nearly 5 million patients in the world suffer from corneal blindness. The cornea is a transparent multilayered tissue of the eye that consists of epithelial and endothelial layers and helps focus the light on the retina. However, injuries to the cornea can cause corneal...

Published: 5/9/2024 | Inventor(s): Jennifer Elisseeff, Qiongyu Guo, Shoumyo Majumdar, Anirudha Singh

Keywords(s): Disease Indication, Eye Disorders, Implanted Device, Implants, Keratoconus, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Ophthalmology, Clinical and Disease Specializations > Ophthalmology > Keratoconus

Wound Healing Compositions Comprising Biocompatible Cellulose Hydrogel Membranes and Methods of Use Thereof

Published: 5/9/2024 | Inventor(s): Jennifer Elisseeff, Daniel Mulreany, Qiongyu Guo, Morgana Trexler, Jennifer Breidenich, Jeffrey Maranchi, Iossif Strehin, Jemin Chae, Oliver Schein, Russel Mccally, Jenna Graham, Julia Patrone, Marcia Patchan, Xiomara Calderon-Colon

Keywords(s): Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

3D-printed Bone Extracellular Matrix Scaffold

Decellularized bone particulates are mixed with polycaprolactone (PCL) or another thermoplastic material. The material, when heated above a specific temperature, becomes a viscous liquid PCL suspension with bone particulates that can be extruded from an extrusion-based three-dimensional printer. This allows for the construction of anatomically shaped,...

Published: 5/9/2024 | Inventor(s): Warren Grayson, Jennifer Elisseeff, Ben Hung, Ethan Nyberg, Tram Nguyen

Keywords(s): Disease Indication, Implants, Skeletal Disorders, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices

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