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Hexosamine Analogs for Regenerative Medicine and Diseases Associated with the Musculoskeletal System

Unmet Need:Osteoarthritis (OA) is the most common form of arthritis, affecting an estimated 32.5 million adults in the United States, with an increasing incidence as the population ages (see CDC) . OA is associated with considerable morbidity as a consequence of joint damage, resulting in pain, loss of joint range of motion, and disability. The disease...

Published: 5/9/2024 | Inventor(s): Kevin Yarema, Jennifer Elisseeff, Jeannine Coburn, Udayanath Aich

Keywords(s): Antagonists/Inhibitors, Arthritis, Biologics, Carbohydrates, Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Joint Disorders, Novel, Osteoarthritis, Predicted Novelty, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Rheumatology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Rheumatology > Arthritis, Clinical and Disease Specializations > Rheumatology > Osteoarthritis

Prostaglandin E2 Mediates Sensory Nerve for Bone Formation and Pain of Skeletal Diseases

Unmet NeedMore than 50 million US adults are affected by arthritis, a joint disorder that can result in persistent pain. There is no cure for arthritis, and in the end stages of the disease, joint replacement is often needed. Current approaches to treat arthritis aim to control pain via the use of analgesics and nonsteroidal anti-inflammatory drugs...

Published: 5/9/2024 | Inventor(s): Xu Cao

Keywords(s): Arthritis, Disease Indication, Joint Disorders, Osteoarthritis, Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Rheumatology > Osteoarthritis, Technology Classifications > Therapeutic Modalities > Targets