Search Results - xu+cao

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Novel therapeutic strategy for ankylosing spondylitis and novel preventative strategy for fibrotic scar formation following spinal cord injury

Unmet Need / Invention Novelty: Current treatments for ankylosing spondylitis (AS) and spinal cord injury (SCI) fail to halt progression of AS or prevent the fibrotic scar formation following SCI respectively. There is an unmet need to develop therapeutic strategies that bring disease remission in AS and prevent fibrotic scar formation following SCI.Technical...

Published: 5/10/2024 | Inventor(s): Xu Cao

Keywords(s):

Category(s): Clinical and Disease Specializations > Musculoskeletal > Osteoporosis

Sialylation of TLR2 Recognized by Siglec15 Initiates Cell-Fusion of Osteoclasts

Unmet Need:According to the NIH, up to 24 million Americans suffer from autoimmune disease and the prevalence is rising. Additionally, by 2020 one in two Americans over age 50 are expected to be at risk for developing osteoporosis of the hip and even more will be at risk developing osteoporosis at any site in the skeleton. Research is ongoing to hinder...

Published: 5/10/2024 | Inventor(s): Xu Cao

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity

Therapeutic application of H3K27 demethylase inhibitor for pediatric and juvenile osteoporosis

Unmet NeedChildhood and adolescence are critical periods for bone growth and mineral accrual. Bone mass and strength in this period are influenced by genetic/epigenetic factors, activity, nutrition, and hormones. For children with genetic skeletal disorders or chronic disease, bone growth and mineral accrual are often compromised, leading to osteoporosis...

Published: 5/9/2024 | Inventor(s): Mei Wan, Xu Cao

Keywords(s): Antagonists/Inhibitors, Disease Indication, Osteoporosis, Skeletal Disorders, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Musculoskeletal > Osteoporosis

Prostaglandin E2 Mediates Sensory Nerve for Bone Formation and Pain of Skeletal Diseases

Unmet NeedMore than 50 million US adults are affected by arthritis, a joint disorder that can result in persistent pain. There is no cure for arthritis, and in the end stages of the disease, joint replacement is often needed. Current approaches to treat arthritis aim to control pain via the use of analgesics and nonsteroidal anti-inflammatory drugs...

Published: 5/9/2024 | Inventor(s): Xu Cao

Keywords(s): Arthritis, Disease Indication, Joint Disorders, Osteoarthritis, Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Rheumatology > Osteoarthritis, Technology Classifications > Therapeutic Modalities > Targets

Therapeutic Treatment or Prevention of Heterotopic Ossification

Unmet Need Heterotopic ossification (HO) is the process of bone formation outside of the skeleton in areas such as soft tissue surrounding the joint. When this occurs, patients experience a high increase in pain and limited range of motion in their joint. HO can be caused by trauma to the hip or leg and even when patients have experienced traumatic...

Published: 5/9/2024 | Inventor(s): Xu Cao

Keywords(s): Disease Indication, Single, Skeletal Disorders, Targeted Therapy, Therapeutic Matter, Therapeutics, Therapy Type, Traumatic Injury

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Traumatic Injury, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities

Therapeutic Treating or Preventing Enthesopathy

Unmet NeedOver half of sports injuries involve tendons and entheses (the sites of attachment between ligament and bone). Enthesopathy, a disorder involving the attachment of tendon or ligament, represents one-fourth of tendon diseases and is a difficult disorder to treat. Tendon disorders, which include enthesopathy, represent a considerable socioeconomic...

Published: 5/9/2024 | Inventor(s): Xu Cao

Keywords(s): Disease Indication, Joint Disorders, Single, Skeletal Disorders, Targeted Therapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Rheumatology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Targets