Search Results - clinical+and+disease+specializations+%3e+musculoskeletal

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Semi-hollow or Fully Trabecular Topology Optimized Total Joint Replacement Implants

Unmet NeedOver 2 million joint replacement surgeries are done per year in the United States. However, the biomechanic functionality of joint implants is often limited because of the large discrepancies between the native bone of the patient and the material and structural properties of the metallic implants. In addition to the material of the implant...

Published: 5/9/2024 | Inventor(s): Jarred Bressner, Mikhail Osanov, James Guest

Keywords(s):

Category(s): Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Surgery, Technology Classifications > Medical Devices > Orthopedic Devices, Technology Classifications > Medical Devices > Prosthetics

Therapeutic application of H3K27 demethylase inhibitor for pediatric and juvenile osteoporosis

Unmet NeedChildhood and adolescence are critical periods for bone growth and mineral accrual. Bone mass and strength in this period are influenced by genetic/epigenetic factors, activity, nutrition, and hormones. For children with genetic skeletal disorders or chronic disease, bone growth and mineral accrual are often compromised, leading to osteoporosis...

Published: 5/9/2024 | Inventor(s): Mei Wan, Xu Cao

Keywords(s): Antagonists/Inhibitors, Disease Indication, Osteoporosis, Skeletal Disorders, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Musculoskeletal > Osteoporosis

Biomimetic, Mussel-inspired, Bioactive Bone Graft Substitute Materials for Bony Fusion

Unmet NeedSpinal fusion is the welding together of adjacent vertebrae. Each year, more than 400,000 Americans undergo spinal fusion to treat conditions like neck and back pain, spinal instability, radiculopathy, and myelopathy. These surgeries require many items, such as spinal rods, screws, and cages. In addition, they require a bone graft to fill...

Published: 5/9/2024 | Inventor(s): Timothy Witham, Ethan Cottrill

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Tissue Substrates, Clinical and Disease Specializations > Musculoskeletal

Vertebral Body Manipulation Device and Methods

Unmet NeedSpinal deformity occurs frequently and may affect up to 68% of the elderly population. Left untreated, these deformities may develop into spondylolisthesis, a spinal misalignment caused by a stress fracture in the vertebra and displacement of the vertebra from its original location. Spondylolisthesis occurs in about 5.8% of men and 9.1% of...

Published: 5/9/2024 | Inventor(s): Dan Stoianovici, Jean-Paul Wolinsky

Keywords(s): Disease Indication, Interventional and Surgical Systems, Skeletal Disorders, Surgical Intervention Method

Category(s): Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

Mixed Reality for Cranial and Facial Reconstruction

Unmet NeedCranioplasty is a procedure for skull reconstruction after removal of bone defects such as tumors. This procedure is currently performed by a surgeon using a marker to draw an outline on the implant that represents the actual deformity of a patient’s head. They then use a handheld surgical cutting tool to trim off the edge of the customized...

Published: 5/9/2024 | Inventor(s): Shuya Liu, javad Fotouhi, Chad Gordon, Mehran Armand

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Traumatic Injury > Craniomaxillofacial Trauma

Tll1 Bmp1 Double Mutant – JHU Developed

Invention Novelty: The Johns Hopkins researchers have developed BTKO mice having floxed alleles for both Bmp1 and Tll1, such that they can be conditionally knocked out either temporally, postnatally, or in a tissue-specific, non-lethal manner and have overcome issues of functional redundancy. Value Proposition: Osteogenesis imperfecta (OI), or brittle...

Published: 5/9/2024 | Inventor(s): Se-Jin Lee

Keywords(s): Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Skeletal Disorders, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Therapeutic Treatment or Prevention of Heterotopic Ossification

Unmet Need Heterotopic ossification (HO) is the process of bone formation outside of the skeleton in areas such as soft tissue surrounding the joint. When this occurs, patients experience a high increase in pain and limited range of motion in their joint. HO can be caused by trauma to the hip or leg and even when patients have experienced traumatic...

Published: 5/9/2024 | Inventor(s): Xu Cao

Keywords(s): Disease Indication, Single, Skeletal Disorders, Targeted Therapy, Therapeutic Matter, Therapeutics, Therapy Type, Traumatic Injury

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Traumatic Injury, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities

Therapeutic Treating or Preventing Enthesopathy

Unmet NeedOver half of sports injuries involve tendons and entheses (the sites of attachment between ligament and bone). Enthesopathy, a disorder involving the attachment of tendon or ligament, represents one-fourth of tendon diseases and is a difficult disorder to treat. Tendon disorders, which include enthesopathy, represent a considerable socioeconomic...

Published: 5/9/2024 | Inventor(s): Xu Cao

Keywords(s): Disease Indication, Joint Disorders, Single, Skeletal Disorders, Targeted Therapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Rheumatology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Targets

Remote Center of Motion Robot

Unmet NeedImage-guided interventions (IGI) may be performed based on pre-acquired images, but using the imager at the time of the intervention to directly guide the procedure improves accuracy. Compatibility of robotic devices with the imaging has been a challenging engineering task, especially with magnetic resonance (MR) environment. Technology OverviewThis...

Published: 5/9/2024 | Inventor(s): Dan Stoianovici, Doru Petrisor, Changhan Jun, Sunghwan Lim

Keywords(s): Bone Cancer, Cancers, Disease Indication, Interventional and Surgical Systems, Robotic Surgical System Hardware, Surgical Navigation

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Oncology > Bone Cancer, Technology Classifications > Computers, Electronics & Software > Robotics, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology

3D-printed Bone Extracellular Matrix Scaffold

Decellularized bone particulates are mixed with polycaprolactone (PCL) or another thermoplastic material. The material, when heated above a specific temperature, becomes a viscous liquid PCL suspension with bone particulates that can be extruded from an extrusion-based three-dimensional printer. This allows for the construction of anatomically shaped,...

Published: 5/9/2024 | Inventor(s): Warren Grayson, Jennifer Elisseeff, Ben Hung, Ethan Nyberg, Tram Nguyen

Keywords(s): Disease Indication, Implants, Skeletal Disorders, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices

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