Search Results - skeletal+disorders

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Therapeutic application of H3K27 demethylase inhibitor for pediatric and juvenile osteoporosis

Unmet NeedChildhood and adolescence are critical periods for bone growth and mineral accrual. Bone mass and strength in this period are influenced by genetic/epigenetic factors, activity, nutrition, and hormones. For children with genetic skeletal disorders or chronic disease, bone growth and mineral accrual are often compromised, leading to osteoporosis...

Published: 5/9/2024 | Inventor(s): Mei Wan, Xu Cao

Keywords(s): Antagonists/Inhibitors, Disease Indication, Osteoporosis, Skeletal Disorders, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Musculoskeletal > Osteoporosis

Smart Ankle Bracelet for Monitoring Limb Perfusion

Unmet NeedPerfusion is the method in which blood is delivered to tissue in animals. All animal tissues require adequate supplies of blood for sustained health and life. However, there are many surgeries and procedures that can decrease adequate perfusion. For example, critical limb ischemia (CLI), which affects more than 2 million people in the United...

Published: 5/9/2024 | Inventor(s): Andrew Schulick, Luke Marone

Keywords(s): Disease Indication, Orthotics, Skeletal Disorders, Therapeutic Devices, Therapeutics

Category(s): Technology Classifications > Medical Devices > Orthopedic Devices

Vertebral Body Manipulation Device and Methods

Unmet NeedSpinal deformity occurs frequently and may affect up to 68% of the elderly population. Left untreated, these deformities may develop into spondylolisthesis, a spinal misalignment caused by a stress fracture in the vertebra and displacement of the vertebra from its original location. Spondylolisthesis occurs in about 5.8% of men and 9.1% of...

Published: 5/9/2024 | Inventor(s): Dan Stoianovici, Jean-Paul Wolinsky

Keywords(s): Disease Indication, Interventional and Surgical Systems, Skeletal Disorders, Surgical Intervention Method

Category(s): Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

Tll1 Bmp1 Double Mutant – JHU Developed

Invention Novelty: The Johns Hopkins researchers have developed BTKO mice having floxed alleles for both Bmp1 and Tll1, such that they can be conditionally knocked out either temporally, postnatally, or in a tissue-specific, non-lethal manner and have overcome issues of functional redundancy. Value Proposition: Osteogenesis imperfecta (OI), or brittle...

Published: 5/9/2024 | Inventor(s): Se-Jin Lee

Keywords(s): Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Skeletal Disorders, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Therapeutic Treatment or Prevention of Heterotopic Ossification

Unmet Need Heterotopic ossification (HO) is the process of bone formation outside of the skeleton in areas such as soft tissue surrounding the joint. When this occurs, patients experience a high increase in pain and limited range of motion in their joint. HO can be caused by trauma to the hip or leg and even when patients have experienced traumatic...

Published: 5/9/2024 | Inventor(s): Xu Cao

Keywords(s): Disease Indication, Single, Skeletal Disorders, Targeted Therapy, Therapeutic Matter, Therapeutics, Therapy Type, Traumatic Injury

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Traumatic Injury, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities

Therapeutic Treating or Preventing Enthesopathy

Unmet NeedOver half of sports injuries involve tendons and entheses (the sites of attachment between ligament and bone). Enthesopathy, a disorder involving the attachment of tendon or ligament, represents one-fourth of tendon diseases and is a difficult disorder to treat. Tendon disorders, which include enthesopathy, represent a considerable socioeconomic...

Published: 5/9/2024 | Inventor(s): Xu Cao

Keywords(s): Disease Indication, Joint Disorders, Single, Skeletal Disorders, Targeted Therapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Rheumatology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Targets

3D-printed Bone Extracellular Matrix Scaffold

Decellularized bone particulates are mixed with polycaprolactone (PCL) or another thermoplastic material. The material, when heated above a specific temperature, becomes a viscous liquid PCL suspension with bone particulates that can be extruded from an extrusion-based three-dimensional printer. This allows for the construction of anatomically shaped,...

Published: 5/9/2024 | Inventor(s): Warren Grayson, Jennifer Elisseeff, Ben Hung, Ethan Nyberg, Tram Nguyen

Keywords(s): Disease Indication, Implants, Skeletal Disorders, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices

CCL20 Reporter and Conditional Knockout Mice

TITLE CCL20 Reporter and Conditional Knockout MiceCASE NUMBERC13357ABSTRACTCCL20 a member of the macrophage inflammatory protein family and signal through the receptor CCR6, genomic location have been identified as a region important for bone quality. However, the role of CCL20 signaling in regulating...

Published: 5/9/2024 | Inventor(s): Scott Kominsky

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Inflammatory Disorders, Knock Out Mouse Model, Mouse Model, Skeletal Disorders

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Inflammation

Detecting Osteoporosis Using Photoacoustic Spectroscopy

C12808 Photoacoustic Osteoarthritis DiagnosisInvention Novelty: A novel method that performs early detection of osteoarthritis through a low-cost, portable photoacoustic imaging system.Value Proposition: Osteoporosis affects 15 million Americans, with an additional 30 million considered at risk for the disease. The current standard of care for osteoarthritis...

Published: 5/9/2024 | Inventor(s): Jin Kang, Hyun-Jae Kang, Behnoosh Tavakoli, Xiaoyu Guo, Emad Boctor

Keywords(s): Clinical Diagnostics, Diagnostic Tool, Disease Indication, Image Processing Software, Image Reconstruction Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Measurement Tool, Osteoporosis, Photoacoustic, Skeletal Disorders

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal > Osteoporosis, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Medical Devices > Orthopedic Devices

Reprogramming Blood Cells from Healthy Donors and Patients to Pluripotent and Multipotent Stem Cells

C10865: Novel method to reprogram blood cells to pluripotent and multipotent stem cellsValue Proposition: JHU scientists have developed a method to reprogram human CB, adult bone marrow and peripheral blood cells from healthy donors without any pretreatment to pluripotent and multipotent stem cells. • This novel method uses easily accessible...

Published: 5/9/2024 | Inventor(s): Linzhao Cheng

Keywords(s): Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Osteoporosis, Skeletal Disorders, Stem Cells, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools, Clinical and Disease Specializations > Endocrinology