Search Results - udayanath+aich

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Hexosamine Analogs for Regenerative Medicine and Diseases Associated with the Musculoskeletal System

Unmet Need:Osteoarthritis (OA) is the most common form of arthritis, affecting an estimated 32.5 million adults in the United States, with an increasing incidence as the population ages (see CDC) . OA is associated with considerable morbidity as a consequence of joint damage, resulting in pain, loss of joint range of motion, and disability. The disease...

Published: 5/9/2024 | Inventor(s): Kevin Yarema, Jennifer Elisseeff, Jeannine Coburn, Udayanath Aich

Keywords(s): Antagonists/Inhibitors, Arthritis, Biologics, Carbohydrates, Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Joint Disorders, Novel, Osteoarthritis, Predicted Novelty, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Rheumatology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Rheumatology > Arthritis, Clinical and Disease Specializations > Rheumatology > Osteoarthritis

Novel Hexosamine Reagents for Improved Quality Recombinant Glycoprotein Production

Unmet Need: Glycosylation has a major impact on recombinant glycoproteins with important implications for increasing therapeutic use of these compounds. Various approaches are being developed to afford scientists and engineers more control over the type, location, and amount of sugar added to the protein. One technique involves adding sugar reagents...

Published: 5/9/2024 | Inventor(s): Ruben Almaraz, Udayanath Aich, Kevin Yarema

Keywords(s): Buffer/Media Solution, Discovery/Research Tools, Research Reagent, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools

Deconvolution and Selective Control of Specific Biological Activities with Partially Acylated and Mixed SCFA-derivatized Monosaccharide-SCFA Hybrid Molecules

Value Proposition: This invention solves two problems inherent with the use of Short Chain Fatty Acid (SCFA)-monosaccharide hybrid molecules to modulate cellular activity. The first problem is the toxicity of former versions of these compounds. The current invention uses structure activity relationships as it has been discovered to either enhance or...

Published: 5/9/2024 | Inventor(s): Christopher Weier, Srinivasagopalan Sampathkumar, Christopher Campbell, Udayanath Aich, Sean Choi, Michael Meledeo, Kevin Yarema

Keywords(s): Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Short Chain Fatty Acid (SCFA) - Carbohydrate Bifunctional Hybrid Molecules with Novel Anti-cancer Properties

C04704: Short Chain Fatty Acid (SCFA) - Carbohydrate Bifunctional Hybrid Molecules with Novel Anti-cancer Properties Value Proposition: Butyrate, a natural short chain fatty acid (SCFA), is well-established to have anti-cancer properties via its ability to induce cell cycle arrest and apoptosis in cancer cells. Currently, several clinical trials are...

Published: 5/9/2024 | Inventor(s): Mark Jones, Udayanath Aich, Srinivasagopalan Sampathkumar, Christopher Campbell, Kevin Yarema

Keywords(s): Biologics, Cancers, Carbohydrates, CNS and Neurological Disorders, Disease Indication, Parkinson's Disease, Single, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities