Search Results - parkinson%27s+disease

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Inhibition of rip kinases for treating neurodegenerative disorders

Unmet NeedNeurodegenerative disorders are a heterogeneous group that includes Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), dementia, and Huntington’s disease. These disorders result from progressive degeneration of the structure, function, and network of neurons in the central nervous...

Published: 5/9/2024 | Inventor(s): Seulki Lee, Han Seok Ko, Ted Dawson, Martin Pomper, Donghoon Kim, Yumin Oh, Seung-Hwan Kwon, Yong Joo Park

Keywords(s): Alzheimer's Disease, Antagonists/Inhibitors, CNS and Neurological Disorders, Disease Indication, Neurodegenerative Diseases, Parkinson's Disease, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Parkinson’s Disease

Farnesylation of PARIS Prevents Dopaminergic Neurodegeneration in Models of Parkinson’s Disease

Unmet Need: Parkinson's disease (PD) is an incurable progressive neurodegenerative disease. It is characterized clinically by motor dysfunction that is due to the preferential loss of dopaminergic neurons in the brain. Current treatment strategies for PD are mainly limited to the management of the motor symptoms with drugs such as L-DOPA or dopamine...

Published: 5/9/2024 | Inventor(s): Ted Dawson, Valina Dawson, Joo-Ho Shin, Yunjong Lee, Areum Jo

Keywords(s): Agonists/Promoters, CNS and Neurological Disorders, Disease Indication, Non-novel, Off-the-shelf, Parkinson's Disease, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Parkinson's Disease

Detection of PAR for a Diagnosis in the CSF of Parkinson’s Disease (PD) Patients

Unmet Need Parkinson’s disease (PD) is a common neurodegenerative disease characterized by a gradual loss of all motor function. Currently, no diagnostic test exists for PD. Nevertheless, the early diagnosis of PD is critical for successful disease management as pharmacological treatments like levodopa are most effective when administered at the earliest...

Published: 5/9/2024 | Inventor(s): Ted Dawson, Valina Dawson, Tae-In Kam, Liana Rosenthal, Shaida Andrabi

Keywords(s): Assay, Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Parkinson's Disease

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Parkinson's Disease

Stimulation of Dendrite Growth and Spine Formation by Norrin and LGR6: A Target for Therapy in CNS Injury and Degeneration

Unmet NeedAstroglial dysfunction is associated with the development of numerous central nervous system (CNS) diseases, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Huntington’s disease (HD). Astroglia are the homeostatic cells of the central nervous system and play key roles in the development and support of neuronal...

Published: 5/9/2024 | Inventor(s): Sean Miller, Jeffrey Rothstein

Keywords(s): Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Biologics, CNS and Neurological Disorders, Dementia, Disease Indication, Huntington's Disease, Parkinson's Disease, Protein, Target, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Neurology > Amyotrophic Lateral Sclerosis, Clinical and Disease Specializations > Neurology > Dementia, Technology Classifications > Therapeutic Modalities > Proteins, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Parkinson’s Disease

Identification of LAG3 as the α-synuclein Neuronal Transmission Receptor

Unmet Need: Parkinson’s disease (PD) is the second most common neurodegenerative disorder and leads to slowness of movement, tremor, rigidity, and, in the later stages of PD, cognitive impairment. Pathologically, PD is characterized by the accumulation of α-synuclein in Lewy bodies and neurites. Emerging evidence indicates that the pathogenesis of Parkinson's...

Published: 5/9/2024 | Inventor(s): Ted Dawson, Valina Dawson, Han Seok Ko, Xiaobo Mao, Dario Vignali, Creg Workman

Keywords(s): Biomarker, CNS and Neurological Disorders, Disease Indication, Mechanism-of-action Biomarker, Parkinson's Disease, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities

Generation of Tetracycline-Regulatable Conditional AIMP2 (Aminoacyl-tRNA Synthetase Complex-interacting Multifunctional Protein 2) Transgenic Mice

Transgenic Mouse Model for Parkinson’s Disease JHU REF: [C12196] Invention novelty: This tangible material is a transgenic mice model expressing AIMP2 (Aminoacyl-tRNA synthetase complex-interacting multifunctional protein 2), a protein strongly associated with pathogenesis of Parkinson’s disease (PD). Value Proposition: No animal models overexpressing...

Published: 5/9/2024 | Inventor(s): Lino Tessarollo, Valina Dawson, Yunjong Lee, Debbie Swing, Ted Dawson

Keywords(s): CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Parkinson's Disease, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Non-invasive brain stimulation method for improvement of motor symptoms in Parkinsons Disease

Non-Invasive Treatment to Improve Motor Function for Parkinson’s DiseaseJHU REF: C13031Invention Novelty: A minimally invasive method and device for symptom management and treatment of early stage Parkinson's disease (PD) using transcranial direct current stimulation (tDCS). Value Proposition:Current treatments for PD have known issues associated...

Published: 5/9/2024 | Inventor(s): Zoltan Mari, Yousef Salimpour, Reza Shadmehr

Keywords(s): Brain Stimulation, CNS and Neurological Disorders, Disease Indication, Interventional and Surgical Systems, Parkinson's Disease, Surgical Intervention Method, Transcranial Direct Current Stimulation

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Neurology

Short Chain Fatty Acid (SCFA) - Carbohydrate Bifunctional Hybrid Molecules with Novel Anti-cancer Properties

C04704: Short Chain Fatty Acid (SCFA) - Carbohydrate Bifunctional Hybrid Molecules with Novel Anti-cancer Properties Value Proposition: Butyrate, a natural short chain fatty acid (SCFA), is well-established to have anti-cancer properties via its ability to induce cell cycle arrest and apoptosis in cancer cells. Currently, several clinical trials are...

Published: 5/9/2024 | Inventor(s): Mark Jones, Udayanath Aich, Srinivasagopalan Sampathkumar, Christopher Campbell, Kevin Yarema

Keywords(s): Biologics, Cancers, Carbohydrates, CNS and Neurological Disorders, Disease Indication, Parkinson's Disease, Single, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities

An Inducible Reconstitution and Real-time Quantitative Kinetic System for the Analysis of Catalysis and Inhibition in Membranes

C12181: An assay to evaluate membrane-immersed enzyme kinetics in real time.Novelty: This technology is an inducible and real-time quantitative kinetic assay for the analysis of intra-membrane proteolysis.Value Proposition: Intra-membrane proteases can catalyze hydrolysis immersed within membranes. These enzymes are implicated in diseases such as Alzheimers...

Published: 5/9/2024 | Inventor(s): Seth Dickey, Rosanna Baker, Sinisa Urban

Keywords(s): Alzheimer's Disease, Assay, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, In Vitro Diagnostics, Infectious Diseases, Malaria, Parkinson's Disease, Tuberculosis (TB)

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Clinical and Disease Specializations > Neurology > Parkinson’s Disease

Discovery and Characterization of Thorase Protein - transgenic mice

C11179: Trangenic AAA+ ATPase Thorase Knock-out mouse lineValue Proposition: Published as Zhang et al. The AAA(+) ATPase Thorase Regulates AMPA Receptor-Dependent Synaptic Plasticity and Behavior. Cell. 2011. Apr 15;145(2):284-99.Technical Details: Many millions of people battle chronic neurological conditions and diseases worldwide. This discovery...

Published: 5/9/2024 | Inventor(s): Jianmin Zhang, Ted Dawson, Valina Dawson

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Parkinson's Disease

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