Search Results - valina+dawson

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Diagnosis of PD and Related α-synucleinopathies through Assessment of and c-Abl Pathway Molecules from Serum or Plasma L1Cam+ Exosomes

Unmet NeedMore than 10 million people worldwide are currently living with Parkinson’s disease (PD), which is a neurodegenerative disorder that affects movement through degeneration of the dopamine-producing (DA) neurons in the brain. The cause of PD is currently unknown, and no specific tests exist to diagnose the disease. Neurologists diagnose PD based...

Published: 5/9/2024 | Inventor(s): Ted Dawson, Liana Rosenthal, Saurav Brahmachari, Tae-In Kam, Valina Dawson

Keywords(s):

Category(s): Technology Classifications > Diagnostics > Diagnostic Biomarkers

Farnesylation of PARIS Prevents Dopaminergic Neurodegeneration in Models of Parkinson’s Disease

Unmet Need: Parkinson's disease (PD) is an incurable progressive neurodegenerative disease. It is characterized clinically by motor dysfunction that is due to the preferential loss of dopaminergic neurons in the brain. Current treatment strategies for PD are mainly limited to the management of the motor symptoms with drugs such as L-DOPA or dopamine...

Published: 5/9/2024 | Inventor(s): Ted Dawson, Valina Dawson, Joo-Ho Shin, Yunjong Lee, Areum Jo

Keywords(s): Agonists/Promoters, CNS and Neurological Disorders, Disease Indication, Non-novel, Off-the-shelf, Parkinson's Disease, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Parkinson's Disease

Detection of PAR for a Diagnosis in the CSF of Parkinson’s Disease (PD) Patients

Unmet Need Parkinson’s disease (PD) is a common neurodegenerative disease characterized by a gradual loss of all motor function. Currently, no diagnostic test exists for PD. Nevertheless, the early diagnosis of PD is critical for successful disease management as pharmacological treatments like levodopa are most effective when administered at the earliest...

Published: 5/9/2024 | Inventor(s): Ted Dawson, Valina Dawson, Tae-In Kam, Liana Rosenthal, Shaida Andrabi

Keywords(s): Assay, Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Parkinson's Disease

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Parkinson's Disease

Cultured Networks of Excitatory Projection Neurons and Inhibitory Interneurons for Studying Human Cortical Neurotoxicity

Unmet Need: Translating neuroprotective treatments from discovery in cell and animal models to the clinic has proven challenging. To reduce the gap between basic studies of neurotoxicity and neuroprotection and clinically relevant therapies, JHU scientists developed a human cortical neuron culture system from human embryonic stem cells or human inducible...

Published: 5/9/2024 | Inventor(s): Ted Dawson, Valina Dawson, Jinchong Xu, Jing Fan

Keywords(s): Antagonists/Inhibitors, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Neurons, Small Molecules, Stroke, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Stroke, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

Identification of LAG3 as the α-synuclein Neuronal Transmission Receptor

Unmet Need: Parkinson’s disease (PD) is the second most common neurodegenerative disorder and leads to slowness of movement, tremor, rigidity, and, in the later stages of PD, cognitive impairment. Pathologically, PD is characterized by the accumulation of α-synuclein in Lewy bodies and neurites. Emerging evidence indicates that the pathogenesis of Parkinson's...

Published: 5/9/2024 | Inventor(s): Ted Dawson, Valina Dawson, Han Seok Ko, Xiaobo Mao, Dario Vignali, Creg Workman

Keywords(s): Biomarker, CNS and Neurological Disorders, Disease Indication, Mechanism-of-action Biomarker, Parkinson's Disease, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities

Identification of a Novel AIF3 Isoform

TITLEIdentification of a novel AIF3 isoformCASE NUMBERC13339 ABSTRACTApoptosis-inducing factor (AIF) is a bifunctional flavoprotein with a vital function in bioenergetics within mitochondria and a lethal function in cell death when it moves to the nucleus. We identified a novel AIF isoform AIF3 in mouse brain by 5’ RACE. AIF3 lacks exons 2 and 3, which...

Published: 5/9/2024 | Inventor(s): Ted Dawson, Valina Dawson, Masayuki Sasaki, Yingfei Wang

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Growth Factors, Neurodegeneration, Neurodegenerative Diseases, Recombinant Proteins, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Generation of Tetracycline-Regulatable Conditional AIMP2 (Aminoacyl-tRNA Synthetase Complex-interacting Multifunctional Protein 2) Transgenic Mice

Transgenic Mouse Model for Parkinson’s Disease JHU REF: [C12196] Invention novelty: This tangible material is a transgenic mice model expressing AIMP2 (Aminoacyl-tRNA synthetase complex-interacting multifunctional protein 2), a protein strongly associated with pathogenesis of Parkinson’s disease (PD). Value Proposition: No animal models overexpressing...

Published: 5/9/2024 | Inventor(s): Lino Tessarollo, Valina Dawson, Yunjong Lee, Debbie Swing, Ted Dawson

Keywords(s): CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Parkinson's Disease, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Discovery and Characterization of Thorase Protein - transgenic mice

C11179: Trangenic AAA+ ATPase Thorase Knock-out mouse lineValue Proposition: Published as Zhang et al. The AAA(+) ATPase Thorase Regulates AMPA Receptor-Dependent Synaptic Plasticity and Behavior. Cell. 2011. Apr 15;145(2):284-99.Technical Details: Many millions of people battle chronic neurological conditions and diseases worldwide. This discovery...

Published: 5/9/2024 | Inventor(s): Jianmin Zhang, Ted Dawson, Valina Dawson

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Parkinson's Disease

Conditional Alpha Synuclein Transgenic Mice

C10840: Conditional Alpha Synuclein Transgenic MiceValue Proposition: JHU Inventors have developed conditional alpha-synuclein transgenic mice that can express A53T, E46K or C-terminally truncated alpha-synuclein. ADVANTAGES - Effects of different pathological variants of the alpha-synuclein protein can be directly compared in the ROSA26-alphaSyn mice...

Published: 5/9/2024 | Inventor(s): Valina Dawson, Mingyao Ying, Darren Moore, Ted Dawson

Phosphospecific LRRK2 Antibodies to Monitor Activation State of LRRK2

C10751: Phosphospecific LRRK2 Antibodies to Monitor Activation State of LRRK2Value Proposition: Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are responsible for late-onset autosomal dominant Parkinson's disease (PD). LRRK2 may have roles in pathogenesis of several neurodegenerative disorders. Inventors have produced antibodies that can...

Published: 5/9/2024 | Inventor(s): Darren Moore, Xiaojie Li, Valina Dawson, Ted Dawson

Keywords(s): Antibodies, Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Parkinson's Disease, Polyclonal Antibodies, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Research Tools > Antibodies, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

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