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A DNA Vaccine for Eliciting T Cell Immunity in the Lung

Unmet NeedRespiratory pathogens are a major contributor to global economic and public health crises. In the wake of the COVID-19 pandemic, new vaccine technologies have been developed to improve the response to emerging pathogens. However, questions remain regarding how to deal with pathogens that have the potential to cause future pandemics. New vaccination...

Published: 5/10/2024 | Inventor(s): Richard Markham, James Gordy, Petros Karakousis

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Covid-19, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Technology Classifications > Therapeutic Modalities > Vaccines

Method to Enhance Pulmonary Dendritic Cell-mediated DNA Vaccination

Unmet NeedWith lung diseases, namely influenza and lung cancer, on the rise, pulmonary vaccination is a promising approach to elicit strong immunity to inhaled pathogens and lung cancer compared to systemic immunization strategies. In particular, inhaled DNA vaccination, a rapidly developing field, can potentially promote humoral and cellular immunity...

Published: 5/9/2024 | Inventor(s): Jung Soo Suk, Yoo Chun Kim, Justin Hanes

Keywords(s): Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Immunotherapy, Infectious Diseases, Influenza, Lung Cancer, Nanoparticles, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Tuberculosis (TB), Vaccine

Category(s): Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Clinical and Disease Specializations > Infectious Diseases > Influenza, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology > Lung Cancer, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

Identification of Novel Coumestan Derivatives as Pks13 Inhibitors against Mycobacterium Tuberculosis

Unmet NeedTuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis (Mtb), which typically impacts the lungs. In 2016, there were 10.4 million new cases of TB and 1.7 million deaths worldwide, with approximately one-fourth of the world’s population infected. As a result, TB is one of the leading infectious disease...

Published: 5/9/2024 | Inventor(s): William Bishai, Shichun Lun, Li-Fang Yu, Shu-Huan Wang, Fan Yang, Jie Tang, Hendra Gunosewoyo, Ashlee Earl, Abigail Manson, Wei Zhang

Keywords(s): Antagonists/Inhibitors, Disease Indication, Infectious Diseases, Myobacterium Tuberculosis, Natural compounds, Non-novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Tuberculosis (TB)

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB)

An Inducible Reconstitution and Real-time Quantitative Kinetic System for the Analysis of Catalysis and Inhibition in Membranes

C12181: An assay to evaluate membrane-immersed enzyme kinetics in real time.Novelty: This technology is an inducible and real-time quantitative kinetic assay for the analysis of intra-membrane proteolysis.Value Proposition: Intra-membrane proteases can catalyze hydrolysis immersed within membranes. These enzymes are implicated in diseases such as Alzheimers...

Published: 5/9/2024 | Inventor(s): Seth Dickey, Rosanna Baker, Sinisa Urban

Keywords(s): Alzheimer's Disease, Assay, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, In Vitro Diagnostics, Infectious Diseases, Malaria, Parkinson's Disease, Tuberculosis (TB)

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Clinical and Disease Specializations > Neurology > Parkinson’s Disease

Guinea Pig-passaged H37Rv rel Mtb Mutant, rel Complement Strain, rel Tetracycline-inducible Knock-in Strain, rel Tetracycline-inducible Knock-down Strain

C11518: Transgenic rel Tubercle Bacilli for Anti-Tuberculosis Drug ScreeningNovelty: Transgenic guinea pig-passaged tubercle bacilli with modified rel expression levels useful for the identification of novel anti-tuberculosis therapeutics.Value Proposition: To date, tuberculosis (TB) infections are often unrecognized due to the ability of tubercle bacilli...

Published: 5/9/2024 | Inventor(s): Petros Karakousis

Keywords(s): Bacterial Infections, Basic Research Biomarker, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Infectious Diseases, Knock Out Rabbit Model, Rabbit Model, Tuberculosis (TB)

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB)