Search Results - william+bishai

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Identification of Novel Coumestan Derivatives as Pks13 Inhibitors against Mycobacterium Tuberculosis

Unmet NeedTuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis (Mtb), which typically impacts the lungs. In 2016, there were 10.4 million new cases of TB and 1.7 million deaths worldwide, with approximately one-fourth of the world’s population infected. As a result, TB is one of the leading infectious disease...

Published: 5/9/2024 | Inventor(s): William Bishai, Shichun Lun, Li-Fang Yu, Shu-Huan Wang, Fan Yang, Jie Tang, Hendra Gunosewoyo, Ashlee Earl, Abigail Manson, Wei Zhang

Keywords(s): Antagonists/Inhibitors, Disease Indication, Infectious Diseases, Myobacterium Tuberculosis, Natural compounds, Non-novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Tuberculosis (TB)

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB)

Further Improved Derivatives of Isoniazid with Enhanced Activity

Unmet NeedIn 2015, there were approximately 10.4 million new cases of tuberculosis (TB). More than 95% of cases and deaths due to TB are found in developing countries with India, Indonesia, China, Pakistan and South Africa accounting for 60% of global TB cases. TB is an airborne disease that can be easily spread from person to person. The market for...

Published: 5/9/2024 | Inventor(s): Vojo Deretic, Graham Timmins, William Bishai

Keywords(s): Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Lead Indole-2-carboxyamide Derivative Compounds for Treatment of TB

Unmet NeedAlthough effective therapy exists for TB caused by drug-susceptible mycobacterium tuberculosis, this therapy requires daily administration of multiple drugs for a minimum of 6 months. The consequence of noncompliance with the existing TB treatment leads to the development of drug-resistant TB in which case both first-line and second-line drug...

Published: 5/9/2024 | Inventor(s): Shichun Lun, Alan Kozikowski, Jozef Stec, Oluseye Onajole, Haidan Guo, William Bishai

Keywords(s): Antagonists/Inhibitors, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Molecular Target of Mycobacterium Tuberculosis for Development of Drug and Vaccine

Susceptibility Target for TB TherapyJHU REF: C10895Invention novelty: This invention has identified a new target and a new way to kill the Mycobacterium tuberculosis pathogen.Value Proposition: Currently the mechanism by which M. tuberculosis maintains 3-3 cross-linkages in the peptidoglycan layer is not fully understood. Inventors at JHU and Universite...

Published: 5/9/2024 | Inventor(s): Jean-Luc Mainardi, Marie Lavollay, Michel Arthur, Radhika Gupta, Gyanu Lamichhane, William Bishai

Keywords(s): Bacterial Infections, Biomarker, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Infectious Diseases, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics, Tuberculosis, Tuberculosis (TB)

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

A Library of a Large Collection of Genotypically Defined Mutants

C04275: A Library of a Large Collection of Genotypically Defined Mutants Value Proposition: Tuberculosis is a serious and lethal infectious disease that exists worldwide. There is a recognized need to understand the infectivity mechanisms used by mycobacterium to identify useful therapeutic and prophylactic targets. JHU researchers have generated...

Published: 5/9/2024 | Inventor(s): Deborah Geiman, Gyanu Lamichhane, Matteo Zignol, William Bishai

Keywords(s): Biomarker, Clinical Diagnostics, Computer and Network Systems, Computer Software, Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Database Management Software, In Vitro Diagnostics, Physics

Category(s): Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Diagnostics > Diagnostic Biomarkers