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Improved Production of Clavulanic Acid by Genetic Engineering of Streptomyces Clavuligerus

Clavulanic acid is a potent b-lactamase inhibitor used to combat resistance to penicillin and cephalosporin antibiotics. There is a demand for high-yielding fermentation strains for industrial production of this valuable product. Clavulanic acid biosynthesis is initiated by the condensation of L-arginine and D-glyceraldehyde-3-phosphate (G3P). To overcome...

Published: 5/9/2024 | Inventor(s): Rong-feng Li, Craig Townsend

Keywords(s): Bacterial Infections, Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Disease Indication, Infectious Diseases, Inhibitors, Research Reagent, Therapeutic Method, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

COMPOSITIONS AND METHODS FOR PREPARATION OF COMPOSITE POLYMER FILMS ON NON-CONDUCTING SUBSTRATES, INCLUDING BANDAGES, AND THEIR USE FOR TREATING WOUNDS

Technology DescriptionResearchers at Johns Hopkins have developed a polymer film coating for bandages and/or medical devices. treating or preventing infections. The coating can be used to delivery drugs for the treatment or prevention of infections, as the material can be synthesized to include several bioactive agents immobilized in such a way that...

Published: 5/9/2024 | Inventor(s): Hai-Quan Mao, Lloyd Miller, Alyssa Ashbaugh, Xuesong Jiang, Jesse Zheng, Sashank Reddy, Bartlomiej Kachniarz

Keywords(s): Bacterial Infections, Disease Indication, Drug Delivery Device, Implanted Device, Implants, Infectious Diseases, Medical Devices, Therapeutic Devices

Category(s): Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Inhibitors of Beta Lactamase

Unmet NeedDrug resistance to antibiotics, especially β-lactam antibiotics such as penicillin, cephalosporin and related compounds is one of the most serious problems in the treatment of infectious diseases. It represents not only a significant medical problem, but a major public health and economic burden. Reports from the Center for Disease Control...

Published: 5/9/2024 | Inventor(s): Samuel Milstein, Irene Luque, Xiao Yingxin, Raphael Ottenbrite, Patrick Ross, Ernesto Freire

Keywords(s): Antagonists/Inhibitors, Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

B7-DC Variants in the Stimulation of Immune Responses

Unmet NeedUnfortunately, many human tumor cells have evolved ways of deactivating the body’s immune system by expressing inhibitory signals (e.g., PD-L1, CTLA-4) on tumor cell surfaces. As a consequence, there is a pressing need for novel immunotherapies that would allow immune cells to bypass specific inhibitory signals on tumor cells and carry out...

Published: 5/9/2024 | Inventor(s): Lieping Chen

Keywords(s): Bacterial Infections, Biologics, Cancers, Disease Indication, Immunotherapy, Infectious Diseases, Peptide, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

New Antibacterials Against D,D- and L,D-Transpeptidases

Unmet needb-lactam antibacterial agents target peptidoglycan biosynthesis and are used for treatment of infection, but have been ineffective in treatment of Tuberculosis (TB). This lack of activity has been attributed to the presence of b-lactamase and limited penetration of the thick mycolate coat. Thus, new generation of antibacterial agents to treat...

Published: 5/9/2024 | Inventor(s): Craig Townsend, Evan Lloyd

Keywords(s): Antagonists/Inhibitors, Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Novel Molecular Method for the Detection of Mycobacterium Tuberculosis

Unmet NeedTuberculosis (TB) is a potentially serious infectious respiratory disease that is spread via coughs and sneezes. TB is one of the world’s deadliest diseases; one-fourth of the global population is currently infected with TB. In 2016 alone, 10.4 million people contracted TB with 1.7 million TB-related deaths. Lack of resources in developing...

Published: 5/9/2024 | Inventor(s): Pankaj Kumar, Gyanu Lamichhane

Keywords(s): Assay, Biomarker, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Infectious Diseases, Tuberculosis

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools > Assays

A Combination of Carbapenem and Avibactam for Treatment of Bacterial Infections

UNMET NEEDMultidrug-resistant (MDR) pathogens, e.g. Mycobacterium tuberculosis (TB) are a growing threat with significant economic ramifications. In particular, TB is one of the top 10 causes of death worldwide, with an estimated 10.4 million people infected, globally. An estimated 1.8 million deaths are attributable to TB. MDR-TB is TB that does not...

Published: 5/9/2024 | Inventor(s): Gyanu Lamichhane

Keywords(s): Antagonists/Inhibitors, Bacterial Infections, Combination, Disease Indication, Infectious Diseases, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

Streamlined Platform for Bacterial Identification and Antimicrobial Susceptibility Test

Unmet NeedFor managing dangerous infections, clinicians need to know what bacteria strain(s) is/are causing the infections, the bacterial loads, and the antibiotic resistance profile of the bacteria. Without knowing this vital information in a timely manner, it is impossible to begin using narrow-spectrum antibiotics that can effectively treat the...

Published: 5/9/2024 | Inventor(s): Tza-Huei (Goes by Jeff) Wang, Pornpat Athamanolap, Liben Chen, Kuangwen Hsieh

Keywords(s): Assay, Bacterial Infections, Clinical Diagnostics, Diagnostic Tool, Disease Indication, In Vitro Diagnostics, Measurement Tool, Microfluidic

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

RiBns for Rhomboid Proteases

This invention describes a method for creating novel, inhibitors of desired bacterial rhomboid proteases (RhP), and applies this method to produce potent antibiotics. The value proposition is very high providing a means of identifying and creating novel, specific bacterial Rhp inhibitors (antibiotics) with a novel mechanism of action to prevent/overcome...

Published: 5/9/2024 | Inventor(s): Sinisa Urban, Shiv Gandhi, Sangwoo Cho

Keywords(s): Antagonists/Inhibitors, Bacterial Infections, Biologics, Disease Indication, Infectious Diseases, Malaria, Parasitic Infections, Peptide, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Therapeutic Modalities > Small Molecules

Clinical Decision Support MDR-TB Application

We have conceptualized and designed a clinical decision support application for MDR-TB. This application will assist clinicians (doctors, nurses, pharmacists) with the following types of information: a) standardized regimens; b) weight-based dosing; c) drug-drug interactions; d) side effect monitoring; e) symptom management; f) adherence to care.

Published: 5/9/2024 | Inventor(s): Jason Farley

Keywords(s): Bacterial Infections, Clinical Workflow Management System, Clinical Workflow Management Tools, Disease Indication, Healthcare Management, Infectious Diseases, Operations Management, Tuberculosis, Tuberculosis (TB)

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis, Technology Classifications > Computers, Electronics & Software > Clinical Management, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases

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