Search Results - ernesto+freire

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Unmet NeedDrug resistance to antibiotics, especially β-lactam antibiotics such as penicillin, cephalosporin and related compounds is one of the most serious problems in the treatment of infectious diseases. It represents not only a significant medical problem, but a major public health and economic burden. Reports from the Center for Disease Control...

Published: 5/9/2024 | Inventor(s): Samuel Milstein, Irene Luque, Xiao Yingxin, Raphael Ottenbrite, Patrick Ross, Ernesto Freire

Keywords(s): Antagonists/Inhibitors, Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

High Affinity Beta Lactamase Inhibitors

C11674: Novel Beta-Lactamase InhibitorsNovelty: This technology comprises of a series of compounds based on a novel scaffold that selectively inhibits the enzyme, beta lactamase with high affinity thereby providing a potential solution to beta-lactam resistance in bacteria.Value Proposition: Development of resistance to currently available beta-lactam...

Published: 5/9/2024 | Inventor(s): Ernesto Freire, Rogelio Siles, Patrick Ross

Keywords(s): Antagonists/Inhibitors, Antibiotic, Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Single, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Small Molecules

High Affinity Chymase Inhibitors

C11636: Novel Chymase Inhibitors for Treatment of AtherosclerosisNovelty: This technology comprises of a series of compounds based on a novel scaffold allowing for selective inhibition of chymase, an enzyme implicated in the development of atheroscleriosis.Value Proposition: Activation of the enzyme chymase, a serine protease sets off a cascade of events...

Published: 5/9/2024 | Inventor(s): Rogelio Siles, Patrick Ross, Ernesto Freire

Keywords(s): Antagonists/Inhibitors, Biomarker, Cardiovascular Diseases, Disease Indication, Mechanism-of-action Biomarker, Novel, Predicted Novelty, Small Molecules, Target, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Cardiovascular > Atherosclerosis

Structural Prediction of Allosterism

C01539: Structural Prediction of AllosterismValue Proposition: During the course of biological function, proteins interact with other proteins, ligands, substrates, inhibitors, etc. These interactions occur at precisely defined locations with the protein but their effects are sometimes propagated to distal regions triggering highly specific responses....

Published: 5/9/2024 | Inventor(s): Ernesto Freire

Keywords(s): Computational Modeling Tool, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, Electrical Digital Data Processing, In Silico Research Tool, Macroscale Modeling, Physics

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Research Tools