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Improved Production of Clavulanic Acid by Genetic Engineering of Streptomyces Clavuligerus

Clavulanic acid is a potent b-lactamase inhibitor used to combat resistance to penicillin and cephalosporin antibiotics. There is a demand for high-yielding fermentation strains for industrial production of this valuable product. Clavulanic acid biosynthesis is initiated by the condensation of L-arginine and D-glyceraldehyde-3-phosphate (G3P). To overcome...

Published: 5/9/2024 | Inventor(s): Rong-feng Li, Craig Townsend

Keywords(s): Bacterial Infections, Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Disease Indication, Infectious Diseases, Inhibitors, Research Reagent, Therapeutic Method, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

Cell Lines Expressing APC in Inducible Manner

C04202: Cell Lines Expressing APC in Inducible Manner Technical Details: JHU scientists have created an inducible expression system for APC in HT-29 colorectal carcinoma cells. Using this novel inducible expression system, it was shown that APC inhibits cell growth through increased apoptosis. Details are described in the paper by Morin et al.,...

Published: 5/9/2024 | Inventor(s): Kenneth Kinzler, Patrice Morin, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Cell Signaling, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Inhibitors, Research Reagent, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

Apolipoprotein C-1 Induced Apoptosis

C04159: Apolipoprotein C-1 Induced Apoptosis Technical Details: Apolipoprotein C-I, a small basic protein in human blood, induces apoptosis in cultured human arterial smooth muscle cells through the neutral sphingomyelin (N-SMase) pathway, and the subsequent second messenger steps. An inhibitor of N-SMase abrogates this effect.Looking for Partners:...

Published: 5/9/2024 | Inventor(s): Peter Kwiterovich, Subroto Chatterjee

Keywords(s): Basic Research Biomarker, Cardiovascular Diseases, Cell Signaling, Discovery/Research Tools, Disease Indication, Inhibitors, Myocardial Infarction (MI), Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Clinical and Disease Specializations > Cardiovascular > Myocardial Infarction

Securin is Required for Chromosomal Stability in Human Cells

C03816: Securin is Required for Chromosomal Stability in Human CellsValue Proposition: ADVANTAGES • hSecurin-/- cells exhibit chromosomal instability • hSecurin-/- cells are defective in their ability to execute anaphase • hSecurin-/- cells have gross aneuploidy • Method to screen for agents that inhibit aneuploidyTechnical...

Published: 5/9/2024 | Inventor(s): Prasad Jallepalli, Christoph Lengauer, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Assay, Biomarker, Cancers, Cell Signaling, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, Inhibitors, Pharmakodynamic Biomarker, Research Reagent, Therapeutic Matter, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities