Search Results - craig+townsend

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Improved Production of Clavulanic Acid by Genetic Engineering of Streptomyces Clavuligerus

Clavulanic acid is a potent b-lactamase inhibitor used to combat resistance to penicillin and cephalosporin antibiotics. There is a demand for high-yielding fermentation strains for industrial production of this valuable product. Clavulanic acid biosynthesis is initiated by the condensation of L-arginine and D-glyceraldehyde-3-phosphate (G3P). To overcome...

Published: 5/9/2024 | Inventor(s): Rong-feng Li, Craig Townsend

Keywords(s): Bacterial Infections, Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Disease Indication, Infectious Diseases, Inhibitors, Research Reagent, Therapeutic Method, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

New Antibacterials Against D,D- and L,D-Transpeptidases

Unmet needb-lactam antibacterial agents target peptidoglycan biosynthesis and are used for treatment of infection, but have been ineffective in treatment of Tuberculosis (TB). This lack of activity has been attributed to the presence of b-lactamase and limited penetration of the thick mycolate coat. Thus, new generation of antibacterial agents to treat...

Published: 5/9/2024 | Inventor(s): Craig Townsend, Evan Lloyd

Keywords(s): Antagonists/Inhibitors, Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

A Method for Late Introduction of the (8R)-Hydroxyl Group in Carbapenem beta-Lactam Antibiotic Synthesis

C10954: Enzymes and Methods for Improved Syntheses of Carbapenem Beta-Lactam AntibioticsValue Proposition:• Regio- and stereospecific introduction of the (8R)-hydroxyl group late in a chemoenzymatic production process• Simpler, more chemically robust starting materials can be used from the outset allowing more vigorous reaction conditions in subsequent...

Published: 5/9/2024 | Inventor(s): Micah Bodner, Michael Freeman, Ryan Phelan, Craig Townsend

Keywords(s): Disease Indication, Infectious Diseases, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

Novel Inhibitors of Bacterial Growth

Novel Inhibitors of Bacterial GrowthJHU REF: C13624Invention novelty: Novel antibacterials that inhibit non-classical transpeptidases.Value Proposition: Resistance to existing antibacterials is being reported at an alarming rate. Therefore, new antibacterials that work by inhibiting novel enzymes would be of high utility in treating bacterial infections....

Published: 5/9/2024 | Inventor(s): Gyanu Lamichhane, Joel Freundlich, Shaogang Li, Sean Ekins, Craig Townsend, Evan Lloyd, Nicole Parrish, Amit Kaushik, Pankaj Kumar

Keywords(s): Antagonists/Inhibitors, Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities