Search Results - therapeutic+method

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Improved Production of Clavulanic Acid by Genetic Engineering of Streptomyces Clavuligerus

Clavulanic acid is a potent b-lactamase inhibitor used to combat resistance to penicillin and cephalosporin antibiotics. There is a demand for high-yielding fermentation strains for industrial production of this valuable product. Clavulanic acid biosynthesis is initiated by the condensation of L-arginine and D-glyceraldehyde-3-phosphate (G3P). To overcome...

Published: 5/9/2024 | Inventor(s): Rong-feng Li, Craig Townsend

Keywords(s): Bacterial Infections, Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Disease Indication, Infectious Diseases, Inhibitors, Research Reagent, Therapeutic Method, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

Methods for Continuous Production of Uniform Polyelectrolyte Nanoparticles

Unmet NeedPolyelectrolyte nanoparticles have been widely used for various therapeutic delivery applications, from low molecular weight drugs to peptides and proteins. They are prepared by mixing oppositely charged polymers in aqueous media and are heterogeneous in terms of size and surface charge. However, current production methods rely on bulk mixing...

Published: 5/9/2024 | Inventor(s): Hai-Quan Mao, Jose Santos, Yong Ren, John-Michael Williford

Keywords(s): Drug Delivery Vehicle, Nanoparticles, Therapeutic Matter, Therapeutic Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Artificial Lymph Nodes for T cell Immunotherapy

Unmet Need Adoptive T cell transfer immunotherapy is a promising approach for treating a variety of cancer tumors. They involve the removal, culture, and expansion of resident T cells ex-vivo several thousand fold before reinfusion back into the body. However, a concern with current culturing methods is their inconsistency in developing and retaining...

Published: 5/9/2024 | Inventor(s): Jonathan Schneck, John Hickey, Hai-Quan Mao

Keywords(s): Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, Immunotherapy, In Vitro Research Tool, Single, Therapeutic Matter, Therapeutic Method, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations > Immuno-Oncology

A Novel Method to Efficiently Synthesize a Biodegradable Dextran to Use as an Efficient Cationic Nanopolymer Carrier for siRNA Delivery

Unmet NeedIn theory, RNA interference (RNAi) can be used to decrease expression of any gene driving a disease or pathology, but has seen limited clinical usage as gene therapy due to technical issues, i.e., small interfering RNA (siRNA) cannot enter cells efficiently due to their weight and charge. As such, a carrier molecule is needed to bring siRNA...

Published: 5/9/2024 | Inventor(s): Zaver Bhujwalla, Zhihang Chen

Keywords(s): Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Nucleic Acid, Polymers, Therapeutic Matter, Therapeutic Method, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Research Tools > Nucleic Acids

Developing an Interactive, Personalized Safety Decision Smart Phone Application to Prevent and Respond to Intimate Partner Violence in College Women

Technology OverviewThis technology is a personalized safety decision application for access through smart phones targeting college women. The safety decision-making process (e.g., knowing the advantages and disadvantages of the relationship, having enough information to make a safety decision, helping a friend in an abusive relationship) will increase...

Published: 5/9/2024 | Inventor(s): James Case, Nancy Glass

Keywords(s): Education Management, Educational Mobile App, Educational Tools, Operations Management, Therapeutic Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Computers, Electronics & Software > Education Tech

An Insulin-loaded Nanoparticle and the Method for Preparing Thereof

Unmet Need:Repeated injections of insulin is the standard of care for treating Type 1 diabetes, and essential for control and management of Type 2 diabetes. Drawbacks of this treatment include poor patient compliance, discomfort, and an impaired lifestyle, and hypoglycemia. Oral administration of insulin, if successful, could deliver insulin such that...

Published: 5/9/2024 | Inventor(s): Hai-Quan Mao, Jose Santos, Zhiyu He, Huahua Huang, Lixin Liu, Kam Leong, Yongming Chen

Keywords(s): Diabetes, Disease Indication, Drug Delivery Vehicle, Metabolic Disorders, Nanoparticles, Therapeutic Matter, Therapeutic Method, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

A Microfabricated Multiple Actuation Device for Mechanical Conditioning of 3D Microtissues

We have recently demonstrated an approach that enables mechanical stimulation of microtissues via magnetic actuation of magnetic microspheres bonded to one of the cantilevers in each device (ALL THREE ZHAO REFS). This has notably allowed measurement of the mechanical stiffness of such constructs, and hence analysis of the relative contribution of cells...

Published: 5/9/2024 | Inventor(s): Fan Xu, Ruogang Zhao, Tristin Metz, Alan Liu, Yu Shi, Daniel Reich

Keywords(s): Implanted Device, Implants, Therapeutic Devices, Therapeutic Method, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

C13222 - A Novel Method to Reduce H3T3 Phosphorylation in Rapidly Dividing Cells

C13222UNMET NEEDCancer is incredibly difficult to treat, due to the confluence of factors that cause and perpetuate the disease and the difficulty of targeting cancer cells without affecting normal cells. As such, the academic and industry space is perpetually engaged in researching new targets and pharmacological strategies. For the past few decades,...

Published: 5/9/2024 | Inventor(s): Jing Xie, Xin Chen

Keywords(s): Cancers, Disease Indication, Therapeutic Method, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Tailored Activity Program for People with Dementia

C12825: Tailored Activity Program (TAP) for Improved Lifestyle with DementiaNovelty: An individualized home-based intervention program to reduce behavioral challenges, improve engagement for dementia patients and to improve quality of life of both the patient and the caregiver.Value Proposition: Approximately one third of people over 80 years of age...

Published: 5/9/2024 | Inventor(s): Catherine Piersol, Laura Gitlin

Keywords(s): CNS and Neurological Disorders, Dementia, Disease Indication, Education Management, Educational Curriculum, Interactive Learning Module, Medical Education, Neurodegeneration, Operations Management, Therapeutic Method, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Dementia, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology, Technology Classifications > Computers, Electronics & Software > Healthcare IT

Family Spirit Program: Family Strengthening for Native American Communities

C12042: Family Spirit Program: Family Strengthening for Native American CommunitiesNovelty: The invention is a method designed in the form of home visiting intervention program to support young Native American Indian women during pregnancy and 3 years post-partum.Value Proposition: The Family Spirit Program is an evidence-based and culturally tailored...

Published: 5/9/2024 | Inventor(s): John Walkup, Allison Barlow

Keywords(s): Therapeutic Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities

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