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Dextran Hydrogel Scaffolds Enhance Angiogenic Responses and Promote Complete Skin Regeneration During Burn Wound Healing

Unmet Need:Third-degree burns involve damage to both the epidermal and dermal layers and may also entail damage to underlying muscles, bones, and tendons. Such burns heal with thick scars, which result in contractures that distort the surrounding tissue. Deep third-degree burns usually require skin grafting to achieve wound closure, but the cosmetic...

Published: 5/9/2024 | Inventor(s): Guoming Sun, Xianjie Zhang, John Harmon, Sharon Gerecht

Keywords(s): Disease Indication, Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Peptide Hydrogels for Delivery of Immunosuppressive Drugs and Uses Thereof

Unmet NeedMore than 1 million tissue transplantations are performed each year. Organ transplantation therapies are typically combined with immunosuppressive agents to reduce the risk of allograft rejection and to enhance transplant survival. However, current immunosuppressive drugs are administered systemically and have several dose-limiting side effects...

Published: 5/9/2024 | Inventor(s): Giorgio Raimondi, Joel Schneider, Poulami Majumder

Keywords(s): Disease Indication, Drug Delivery Vehicle, Hydrogel, Inflammatory Disorders, Therapeutic Matter, Therapeutics, Tissue/organ transplant rejection

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Compositions and methods for controlled release suprachoroidal drug delivery

Unmet Need / Invention Novelty: Traditional routes of administrating drugs to the eye are limited by lack of efficiency, frequent side effects, and poor patient tolerance of repeated injections into the eye. Injections into the suprachoroidal space (SCS) is an attractive strategy to overcome these limitations and to provide for targeted delivery of...

Published: 5/9/2024 | Inventor(s): Laura Ensign-Hodges, Peter Campochiaro, Justin Hanes, Yoo Chun Kim, Jikui Shen, Jie Fu

Keywords(s): Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Eye Disorders, Hydrogel, Local Ocular, Microspheres, Polymers, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Cell Impregnated Nanofiber Stent Sleeve ("CINSS") for Intravascular Growth Factor Production

Invention novelty:Stem cells are harnessed to create a stent-based “paracrine factor factory” using a novel biodegradable nanofiber sleeve which protects the cells from washout and immune attack, and provides a sheltered in vivo on-stent milieu for the cells to continuously produce and deliver healing growth factors and exosomes to injured tissue.Value...

Published: 5/9/2024 | Inventor(s): Chao-Wei Hwang, Zhiyong Xia, Virginia Bogdan, Jeffrey Brinker, Gary Gerstenblith, Peter Johnston, Steven Schulman, Gordon Tomaselli, Robert Weiss

Keywords(s): Drug Delivery Vehicle, Hydrogel, Implanted Device, Implants, Stent, Therapeutic Devices, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities

Cellulose-Based Hydrogels and Methods of Making Thereof

Unmet NeedHydrogels are water-insoluble polymers with the ability to swell without dissolution and to retain a large portion of solution within their structure. They have many uses, including contact lenses, wound dressings, tissue regenerative applications, orthopedic applications, drug delivery systems, sanitary napkins, cosmetic implants, and other...

Published: 5/9/2024 | Inventor(s): Julia Patrone, Morgana Trexler, Marcia Patchan, Xiomara Calderon-Colon, Jennifer Breidenich, Jeffrey Maranchi, Jennifer Elisseeff, Jenna Graham, Oliver Schein

Keywords(s): Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Therapeutic Nanofiber Hydrogels for Local Treatment of Brain-related Diseases

We have developed a novel type of therapeutic agent-containing liquids that comprise self-assembling peptide nanofibers and physically encapsulated and chemically bound medicinal compounds, capable of transforming into a gel form upon contact with body fluids. The resulting gel can gradually release the incorporated therapeutic agents in a controlled...

Published: 5/9/2024 | Inventor(s): Honggang Cui, Alfredo Quinones-Hinojosa

Keywords(s): CNS and Neurological Disorders, Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics, Topical Administration

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Biocompatible "smart" nanogels as carriers for hydrophobic drugs

The present invention involves a biocompatible nanogel composition for the delivery of hydrophobic substances that are not readily soluble in organic solvents. These nanogels have been designed to contain hydrophobic cores which encapsulate the insoluble molecules, and a hydrophilic shell which allows long term systemic circulation. The nanogels constitute...

Published: 5/9/2024 | Inventor(s): Savita Bisht, Georg Feldmann, Anirban Maitra

Keywords(s): Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Implantable Multilayer 3D Scaffold Consisting of Highly Aligned Electrospun Fibers for Neuronal Regeneration Applications

C10716: Implantable Multilayer 3D Scaffold for Neuronal Regeneration ApplicationsValue Proposition:The multilayer 3D conduit is a superior candidate for nerve repair and clinical regeneration applications.• The novel wall structure made of double-sided fibers increases the opportunities for cell migration so that more cells populate the regenerating...

Published: 5/9/2024 | Inventor(s): Jared Cregg, Han Wang, Michael Mullins, Martin Oudega, Ryan Gilbert, Andres Hurtado

Keywords(s): CNS and Neurological Disorders, Disease Indication, Drug Delivery Vehicle, Hydrogel, Implanted Device, Implants, Spinal Cord Injury, Therapeutic Devices, Therapeutic Matter, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Spinal Cord Injury, Clinical and Disease Specializations > Traumatic Injury, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Medical Devices > Regenerative Medicine

Self-Assembling Verteporfin Amphiphiles (SAVA) for Local Cancer Therapy

Unmet Need: Brain tumors including aggressive Glioblastoma (GBM) remain a large societal burden due to the large number of affected patients and overall poor survival rates. A promising FDA-approved drug verteporfin (VP) was identified that directly targets transcription factors upregulated in GBM, but practical use of this drug to treat GBM is limited...

Published: 5/9/2024 | Inventor(s): Sagar Shah, Juan Carlos Martinez-Gutierrez, Alejandro Ruiz-Valls, Ran Lin, Honggang Cui, Alfredo Quinones-Hinojosa

Keywords(s): Brain Cancer, Cancers, Disease Indication, Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology > Brain Cancer, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Novel Peptide Hydrogels Generating Chemical Exchange Saturation Transfer MRI Contrast and Uses Thereof

C12189: Novel Self-Assembling Peptide Hydrogels for MRINovelty: Self-assembling peptide hydrogels that can function as non-metallic MRI contrast agents.Value Proposition: Currently used metallic or non-metallic MRI contrast agents have some limitations for in vivo imaging such as toxicity or difficulties in distinguishing the contrast from other sources...

Published: 5/9/2024 | Inventor(s): Nikita Oskolkov, Xiaolei Song, Michael Giano, Joel Schneider, Kannie Chan, Michael Mcmahon

Keywords(s): Drug Delivery Vehicle, Hydrogel, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities

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