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Membrane Active Chelators (MACs) as Chemotherapueutic Agents for Treatment of Human African Trypanosomiasis (HAT)

Membrane Activated Chelators (MACs) are proprietary neuroprotective drugs [D-PHARM LTD; Rehovot Isreal] that modulate cell membrane metal ion homeostasis by adopting an inactive conformation outside only in the lipid environment of cell membranes. In this environment, the drugs are able to unable to bind metal ions at their elevated non-physiological...

Published: 5/9/2024 | Inventor(s): Dennis Grab

Keywords(s): Antagonists/Inhibitors, Chemotherapy, Disease Indication, Human African Trypanosomiasis, Human African Trypanosomiasis (HAT), Infectious Diseases, Non-novel, Parasitic Infections, Predicted Novelty, Repurposed, Single, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Human African Trypanosomiasis, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities