Search Results - clinical+and+disease+specializations+%3e+urology

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Tool for Transurethral Deployment and Fixation of Graft for the Management and Treatment of Urethral Strictures

Novel temporary implant can offer a durable treatment for male urethral stricture by converting a complex open reconstructive surgery into a simple procedure.Unmet NeedUrethral stricture disease causes fibrotic narrowing of the urethra leading to incomplete voiding, frequent and painful urination, and high rates of urinary tract infection. Graft-based...

Published: 5/9/2024 | Inventor(s): Chanya Godzich Elakkad, Teja Maruvada, Joseph Pia, Shravya Srigiri, Kendall Covington, Edward Wright

Keywords(s): Disease Indication, Fixation Devices, Interventional and Surgical Systems, Surgical Instruments, Urinary Disorders

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Urology, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices

METHOD OF SIZE MEASUREMENT IN MONO-VISION SCOPE IMAGES

Unmet NeedKidney stone disease affects up to 1 in 8 people (12%) worldwide and is commonly treated by a procedure known as flexible ureteroscopy (URS). During URS, kidney stones are fragmented and extracted through the ureter. URS involves significant intra-operative decision making since surgeons must accurately assess the size of the stone fragments...

Published: 5/9/2024 | Inventor(s): Dan Stoianovici, Brian Matlaga, Sunghwan Lim, Wesley Ludwig

Keywords(s): Disease Indication, Image Processing Software, Imaging and Sensing Systems, In Vivo Medical Imaging, Kidney Disorders, Kidney stones

Category(s): Technology Classifications > Medical Devices > Imaging, Clinical and Disease Specializations > Urology

Rapid Assay for Carcinoma Stem Cells

Unmet NeedWhile cancer therapeutics have drastically improved patient outcomes in numerous indications, novel methods to prevent cancer metastasis and recurrence are needed. Cancer stem cells (CSCs) are a unique subpopulation of a tumor that are more oncogenic and slow-growing than other cancer cells within the tumor. CSCs make up approximately .1-10%...

Published: 5/9/2024 | Inventor(s): William Matsui, Xiaobing He, David Berman

Keywords(s): Antibodies, Biologics, Bladder Cancer, Cancers, Disease Indication, Immunotherapy, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Urology, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Bladder Cancer

Methods to achieve enhanced delivery to the bladder

Unmet Need: Bladder cancer is a global disease, with 540,000 incident cases and 188,000 deaths in 2015 worldwide. In the United States 81,190 patients will be diagnosed in 2018 and 17,240 will die from their disease.(1) The first-line treatment of non-muscle-invasive bladder cancer (NMIBC) is the transurethral resection of bladder tumors (TURBT),...

Published: 5/9/2024 | Inventor(s): Laura Ensign-Hodges, Justin Hanes, Abhijit Date, Trinity Bivalacqua, Max Kates

Keywords(s): Bladder Cancer, Cancers, Chemotherapy, Disease Indication, Drug Delivery Vehicle, Nanoparticles, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Urology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Bladder Cancer

Engulfment Gene GULP1 as a Functional Tumor Suppressor in Urothelial Carcinoma

Invention Novelty:The technology identifies a novel biomarker to detect the presence of bladder cancer via a urine test. The technology could be coupled with existing urine-based cancer tests to improve sensitivity as a diagnostic or to test drug efficacy. Value Proposition:Bladder cancer (BC) is the 6th most common cancer in the US, with approximately...

Published: 5/9/2024 | Inventor(s): Mohammad Hoque, Masamichi Hayashi, Elisa Guida

Keywords(s): Biomarker, Bladder Cancer, Cancers, Disease Indication, Epigenetic, Methylation, Pharmakodynamic Biomarker, Therapeutic Matter, Therapeutics, Urothelial Carcinoma

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Bladder Cancer, Clinical and Disease Specializations > Oncology > Urothelial Carcinoma, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Urology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

PHARMACEUTICAL AGENTS TARGETING CANCER STEM CELLS

UNMET NEEDChronic environmental exposure induces cancer stem cells (CSCs) with SOX2 overexpression, one of the most important CSC factor for urothelial cancer (UC). COX2 and YAP1 coordinately regulate SOX2 expression, and mutually compensate for the reduction of expression of SOX2 to maintain CSCs. Thus targeting the COX2/YAP/SOX2 signaling axis eliminates...

Published: 5/9/2024 | Inventor(s): Mohammad Hoque, David Sidransky, Akira Oki

Keywords(s): Antagonists/Inhibitors, Bladder Cancer, Cancers, Combination, Disease Indication, Non-novel, Predicted Novelty, Small Molecules, Targeted Therapy/Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Urothelial Carcinoma

Category(s): Clinical and Disease Specializations > Oncology > Bladder Cancer, Clinical and Disease Specializations > Oncology > Urothelial Carcinoma, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Urology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets