Search Results - jurgen+bosch

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Unmet NeedIndividuals with impaired immunity, including those with advanced HIV infection, organ transplants, and on immunosuppressive regimens are susceptible to major fungal pathogens, such as Cryptococcus neoformans and Candida albicans. Cryptococcus neoformans is particularly problematic for AIDS patients. Over a million people worldwide suffer...

Published: 5/9/2024 | Inventor(s): Jurgen Bosch, Arturo Casadevall, Eric Jung

Keywords(s): Antagonists/Inhibitors, Disease Indication, Fungal Infections, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Fungal Infections, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

Inhibition of Autophagy in Cancer Lines

There is an unmet need for selective and specific autophagy inhibitors in cancer research and cancer drug development. Many cancer types rely on autophagy, whereby the cell degrades unnecessary or damaged cellular components, to maintain homeostasis of the cell, particularly in the hypoxic environment of rapidly proliferating tumors. Autophagy pathways...

Published: 5/9/2024 | Inventor(s): Jurgen Bosch

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

A novel Malaria vaccine candidate

Novel Peptide Targeting for Malaria Therapeutic ApplicationsJHU REF: C12845Invention Novelty: Use of Plasmodium-derived peptides to reduce red blood cell invasion of Plasmodium parasites for the prevention and treatment of malariaValue Proposition: Malaria is an infectious disease caused by Plasmodium parasites. In order to induce fatal symptoms of...

Published: 5/9/2024 | Inventor(s): Jurgen Bosch, Daisy Colon Lopez, Ryan Smith

Keywords(s): Biologics, Disease Indication, Immunotherapy, Infectious Diseases, Malaria, Parasitic Infections, Peptide, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

Small Molecule Malarial Aldolase-trap Enhancers and Glideosome Inhibitors

C12661: Novel Anti-Malarial Compounds and CompositionsNovelty: This technology provides new classes of anti-malarial compounds and a method to identify such compounds.Value Proposition: Nearly half the worlds population is at risk of acquiring malaria, which is caused by the Plasmodium family of protozoan parasites. Common drugs used to treat malaria...

Published: 5/9/2024 | Inventor(s): Sondra Nemetski, Timothy Cardozo, Jurgen Bosch

Keywords(s): Agonists/Promoters, Antagonists/Inhibitors, Disease Indication, Infectious Diseases, Malaria, Novel, Parasitic Infections, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities