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Unmet NeedUrinary tract infections (UTIs) are infections in any part of the urinary system (e.g., kidney, ureter, bladder, urethra, etc.). They are the most common outpatient infections, with over 7 million patient visits per year, 50-60% of which occur in adult women [1][2]. UTIs are generally diagnosed via urinalysis which can be used to detect changes...

Published: 5/10/2024 | Inventor(s): Stuart Ray, Nicholas Durr, Benjamin Haeffele, Rene Vidal, Gregory McKay, Carolina Pacheco, Taylor Bobrow

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Nucleoside-modified mRNA-lipid nanoparticle lineage vaccine for Hepatitic C

Value Proposition· Compositions for inducing anti-HCV immune responses · Nucleoside-modified RNA encoding one or more HCV antigens to induce robust preventive or therapeutic adaptive immune responses against HCV Unmet Need· Hepatitis C virus (HCV) infection remains a significant clinical burden and is the leading cause of liver transplantation...

Published: 5/10/2024 | Inventor(s): Justin Bailey, Stuart Ray, James Crowe, Andrew Flyak, George Shaw, Drew Weissman

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Category(s): Technology Classifications > Diagnostics

Novel HIV Antiviral Proteins and Their Uses in Therapeutic Methods

Unmet Need: HIV infection remains a significant global health burden despite availability of current antiviral treatments. With increasing drug resistance against available therapeutics, there is an urgent need for additional strategies to treat HIV. Technical Details: Researchers at Johns Hopkins University have identified novel candidates for HIV...

Published: 5/9/2024 | Inventor(s): David Thomas, Ashwin Balagopal, Ramy El-Diwany, Robert Siliciano, Joel Blankson, Stuart Ray, Michael Chattergoon, Justin Bailey

Keywords(s): Biomarker, Disease Indication, HIV, HIV/AIDS, Infectious Diseases, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Deconvolution of polyclonal hepatitis C virus-specific neutralizing antibodies in plasma

Unmet Need: Hepatitis C Virus (HCV) is a leading cause of liver cancer worldwide. Although treatments have been developed, these drugs do not protect against reinfection and are often cost prohibitive to patients. Therefore, there is an urgent need for the development of an effective HCV vaccine. There is currently no efficient method to assess antibody...

Published: 5/9/2024 | Inventor(s): Justin Bailey, Valerie Kinchen, Guido Massaccesi, Stuart Ray, Andrea Lynn Cox

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Know-how

Category(s): Technology Classifications > Research Tools > Assays, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus (HCV)

Hepatitis C virus E1E2 genes stimulating development of broadly neutralizing antibodies

Unmet Need185 million people worldwide are infected with Hepatitis C (HCV). It is a major cause of liver failure and hepatocellular carcinoma. Recent development of potent, oral, interferon-free therapies have improved treatment of HCV significantly, but treatment alone is unlikely to eradicate the disease. There remain the issues of therapy being costly,...

Published: 5/9/2024 | Inventor(s): Justin Bailey, James Crowe, Andrew Flyak, George Shaw, Stuart Ray

Keywords(s): Biologics, Disease Indication, Hepatitis C Virus, Hepatitis C Virus (HCV), Infectious Diseases, Therapeutic Matter, Therapeutic Substance, Therapeutics, Vaccine, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Vaccines, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Genotype 1 HCV Pseudoparticle Library

C11773: Library of Genotype 1 Hepatitis C Virus particlesNovelty: This technology consists of a wide range of human genotype 1 hepatitis C viral (HCV-1) particles, which can be used for research and development of anti-HCV-1 therapies.Value Proposition: Availability of a library of HCV-1 viral particles provides a valuable resource for anti-HCV-1 drug...

Published: 5/9/2024 | Inventor(s): Stuart Ray, William Osburn

Keywords(s): Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Disease Indication, Hepatitis C Virus (HCV), Infectious Diseases, Physics

Category(s): Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus (HCV)

A computational approach for generating representative hepatitis C virus genomic sequences

C11517: Novel Synthetic Genomic Reconstruct for HCV TherapeuticsNovelty: This technology is an optimized synthetic reconstruct of genotype 1a hepatitis C virus (HCV) that is representative of globally-circulating strains of HCVValue Proposition: The reconstructed HCV genotype 1a virus is highly functional without adaptive mutations, which allows it...

Published: 5/9/2024 | Inventor(s): Supriya Munshaw, Lin Liu, Stuart Ray

Keywords(s): Computational Modeling Tool, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, Disease Indication, Hepatitis C Virus (HCV), In Silico Research Tool, Infectious Diseases, Physics

Category(s): Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus (HCV), Technology Classifications > Research Tools

Use of Consensus Sequence as Vaccine Antigen to Enhance Recognition of Virulent Viral Variants

C04630: Use of Consensus Sequence as Vaccine Antigen to Enhance Recognition of Virulent Viral Variants Technical Details: Vaccines for diverse viruses will be most effective when they direct the recipient?s response to recognize the most virulent form of the organism. Scientists at JHU have found that circulating strains of hepatitis C virus (HCV)...

Published: 5/9/2024 | Inventor(s): Andrea Lynn Cox, David Thomas, Stuart Ray

Keywords(s): Biologics, Disease Indication, Hepatitis C Virus, Hepatitis C Virus (HCV), Infectious Diseases, Therapeutic Matter, Therapeutic Substance, Therapeutics, Vaccine, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Therapeutic Modalities > Vaccines, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities