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Compositions and Method for Identification of HCV Vaccine Antigens Capable of Inducing Broadly Neutralizing Antibodies

Unmet Need: Currently, only a small percentage of people infected with Hepatitis C Virus (HCV) are treated with direct-acting antiviral (DAA) therapy worldwide. Whilst effective and safe, DAA remains unavailable to many, especially in resource limited settings, and curative treatment does not prevent continued disease progression or reinfection. To...

Published: 5/10/2024 | Inventor(s): Justin Bailey, Nicole Frumento, Andrea Lynn Cox

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases

Immune cell metabolic profiling to quantify immunosuppression

Unmet Need / Invention Novelty: Treatment with immunosuppressionis required for patients who have undergone solid organ transplantation or who have autoimmune diseases but no standard test exists that can sensitively measure immune cells for the extent of suppression. There is a critical need for a sensitive approach that can quantify the degree of...

Published: 5/10/2024 | Inventor(s): Andrea Lynn Cox, Elizabeth Thompson, Justin Bailey, Katherine Cascino

Keywords(s):

Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Transplantation

Deconvolution of polyclonal hepatitis C virus-specific neutralizing antibodies in plasma

Unmet Need: Hepatitis C Virus (HCV) is a leading cause of liver cancer worldwide. Although treatments have been developed, these drugs do not protect against reinfection and are often cost prohibitive to patients. Therefore, there is an urgent need for the development of an effective HCV vaccine. There is currently no efficient method to assess antibody...

Published: 5/9/2024 | Inventor(s): Justin Bailey, Valerie Kinchen, Guido Massaccesi, Stuart Ray, Andrea Lynn Cox

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Know-how

Category(s): Technology Classifications > Research Tools > Assays, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus (HCV)

Use of Consensus Sequence as Vaccine Antigen to Enhance Recognition of Virulent Viral Variants

C04630: Use of Consensus Sequence as Vaccine Antigen to Enhance Recognition of Virulent Viral Variants Technical Details: Vaccines for diverse viruses will be most effective when they direct the recipient?s response to recognize the most virulent form of the organism. Scientists at JHU have found that circulating strains of hepatitis C virus (HCV)...

Published: 5/9/2024 | Inventor(s): Andrea Lynn Cox, David Thomas, Stuart Ray

Keywords(s): Biologics, Disease Indication, Hepatitis C Virus, Hepatitis C Virus (HCV), Infectious Diseases, Therapeutic Matter, Therapeutic Substance, Therapeutics, Vaccine, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Therapeutic Modalities > Vaccines, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities