Search Results - justin+bailey

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Nucleoside-modified mRNA-lipid nanoparticle lineage vaccine for Hepatitic C

Value Proposition· Compositions for inducing anti-HCV immune responses · Nucleoside-modified RNA encoding one or more HCV antigens to induce robust preventive or therapeutic adaptive immune responses against HCV Unmet Need· Hepatitis C virus (HCV) infection remains a significant clinical burden and is the leading cause of liver transplantation...

Published: 5/10/2024 | Inventor(s): Justin Bailey, Stuart Ray, James Crowe, Andrew Flyak, George Shaw, Drew Weissman

Keywords(s):

Category(s): Technology Classifications > Diagnostics

Compositions and Method for Identification of HCV Vaccine Antigens Capable of Inducing Broadly Neutralizing Antibodies

Unmet Need: Currently, only a small percentage of people infected with Hepatitis C Virus (HCV) are treated with direct-acting antiviral (DAA) therapy worldwide. Whilst effective and safe, DAA remains unavailable to many, especially in resource limited settings, and curative treatment does not prevent continued disease progression or reinfection. To...

Published: 5/10/2024 | Inventor(s): Justin Bailey, Nicole Frumento, Andrea Lynn Cox

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases

Immune cell metabolic profiling to quantify immunosuppression

Unmet Need / Invention Novelty: Treatment with immunosuppressionis required for patients who have undergone solid organ transplantation or who have autoimmune diseases but no standard test exists that can sensitively measure immune cells for the extent of suppression. There is a critical need for a sensitive approach that can quantify the degree of...

Published: 5/10/2024 | Inventor(s): Andrea Lynn Cox, Elizabeth Thompson, Justin Bailey, Katherine Cascino

Keywords(s):

Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Transplantation

Novel HIV Antiviral Proteins and Their Uses in Therapeutic Methods

Unmet Need: HIV infection remains a significant global health burden despite availability of current antiviral treatments. With increasing drug resistance against available therapeutics, there is an urgent need for additional strategies to treat HIV. Technical Details: Researchers at Johns Hopkins University have identified novel candidates for HIV...

Published: 5/9/2024 | Inventor(s): David Thomas, Ashwin Balagopal, Ramy El-Diwany, Robert Siliciano, Joel Blankson, Stuart Ray, Michael Chattergoon, Justin Bailey

Keywords(s): Biomarker, Disease Indication, HIV, HIV/AIDS, Infectious Diseases, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Deconvolution of polyclonal hepatitis C virus-specific neutralizing antibodies in plasma

Unmet Need: Hepatitis C Virus (HCV) is a leading cause of liver cancer worldwide. Although treatments have been developed, these drugs do not protect against reinfection and are often cost prohibitive to patients. Therefore, there is an urgent need for the development of an effective HCV vaccine. There is currently no efficient method to assess antibody...

Published: 5/9/2024 | Inventor(s): Justin Bailey, Valerie Kinchen, Guido Massaccesi, Stuart Ray, Andrea Lynn Cox

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Know-how

Category(s): Technology Classifications > Research Tools > Assays, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus (HCV)

Hepatitis C virus E1E2 genes stimulating development of broadly neutralizing antibodies

Unmet Need185 million people worldwide are infected with Hepatitis C (HCV). It is a major cause of liver failure and hepatocellular carcinoma. Recent development of potent, oral, interferon-free therapies have improved treatment of HCV significantly, but treatment alone is unlikely to eradicate the disease. There remain the issues of therapy being costly,...

Published: 5/9/2024 | Inventor(s): Justin Bailey, James Crowe, Andrew Flyak, George Shaw, Stuart Ray

Keywords(s): Biologics, Disease Indication, Hepatitis C Virus, Hepatitis C Virus (HCV), Infectious Diseases, Therapeutic Matter, Therapeutic Substance, Therapeutics, Vaccine, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Vaccines, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections