Search Results - clinical+and+disease+specializations+%3e+geriatrics

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GCPII Inhibition for the Treatment of Sarcopenia and Aging

Unmet Need:Sarcopenia is the progressive loss of muscle mass and function, and is a natural part of the aging process. Age-related muscle loss and weakness can contribute to frailty and increase the likelihood of falls and fractures in older adults. Recent reports found that 5-13% of persons over the age of 65 years and >50% of people 80 years and...

Published: 5/10/2024 | Inventor(s): Barbara Slusher, Carolyn Tallon

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Geriatrics

Conditional Tau Mouse Lines that Faithfully Recapitulate Alzheimer’s Disease-like Pathologies

Value Proposition: Effective therapy for Alzheimer’s disease (AD), the most common form of dementia and a devastating illness for the elderly, remains a great unmet need. For translational research and preclinical drug development, animal models that faithfully mimic the cardinal pathological features of AD are critical. A major limitation of current...

Published: 5/9/2024 | Inventor(s): Philip Wong, Donald Price, Tong Li

Keywords(s): Alzheimer's Disease, Basic Research Biomarker, Cell Lines, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Mouse Cell Lines, Mouse Model, Neurodegeneration

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Measuring Patient Mobility in the ICU using a Novel Non-Invasive Sensor

Unmet NeedPatient mobilization is a critical variable that can predict future physical impairments and the ultimate length of stay for intensive care unit (ICU) patients. Measuring patient mobilization requires a clinical staff member to monitor a video feed of multiple patients in an ICU ward and make subjective distinctions on their level of mobility....

Published: 5/9/2024 | Inventor(s): Suchi Saria, Andy Jinhua Ma, Austin Reiter

Keywords(s): Accelerometer, Disease Indication, Environmental Sensing, Geriatric Conditions, Imaging and Sensing Systems, Sensors

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Technology Classifications > Computers, Electronics & Software > Sensors, Technology Classifications > Industrial Tech > Energy, Infrastructure & Environment, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Energy, Infrastructure & Environment

Fall Prevention App

This is a smartphone app designed to help patients attending fall prevention clinic. Fall Prevention App was developed to help coordinate care of patients coming to the Hopkins Fall Prevention Clinic with the PMR Department. The app does not collect any patient information and does not communicate this information to anyone else. It is designed to...

Published: 5/9/2024 | Inventor(s): Levan Atanelov

Keywords(s): Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Disease Indication, Falls, Geriatric Conditions, Physics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics > Falls, Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Geriatrics

Biomarkers of Alzheimer's and other Diseases of Cognition

Unmet Need Alzheimer’s disease (AD) results in progressive loss of cognitive function. The common methods of AD diagnoses are clinical observations and medical imaging. As new therapies for AD are discovered, there is a need for simple biomarkers that can be related to the disease pathogenesis. Current biomarkers for AD are unreliable and are not highly...

Published: 5/9/2024 | Inventor(s): Paul Worley, Desheng Xu, Meifang Xiao

Keywords(s): Alzheimer's Disease, Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Neurodegeneration

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology

Oral Glucose Tolerance Test for Mild Cognitive Impairment/Alzheimer's Disease Biomarker Development

UNMET NEEDAlzheimer’s disease is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills, and eventually the ability to carry out the simplest tasks. Treatment of Alzheimer’s disease (AD) is significantly hampered by the lack of easily accessible biomarkers that can detect disease presence and predict disease risk...

Published: 5/9/2024 | Inventor(s): Esther Oh, Constantine Lyketsos, Suzanne Craft

Keywords(s): Alzheimer's Disease, Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Neurodegeneration

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology

MRM Assay Measurement of Amyloid Precursor Protein in Healthy and Alzheimers Disease Cerebrospinal Fluids

C12148: Method for Measuring Amyloid Precursor Proteins for Alzheimer’s DiseaseNovelty: This invention develops a method to measure the concentrations of various forms of Amyloid Precursor Proteins (APP) in cerebrospinal fluid (CSF).Value Proposition: Alzheimer's disease (AD) is the most common form of dementia. There is no cure for the disease....

Published: 5/9/2024 | Inventor(s): Jennifer Van Eyk, Xiaoqian Liu, Richard O'brien

Keywords(s): Alzheimer's Disease, Assay, Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Neurodegeneration, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

BACE2 Knockout Mice

C04556: BACE2 Knockout Mice Technical Details: Two beta-secretases termed BACE1 and BACE2 have been shown to generate the Alzheimer's disease Abeta peptides. To examine the physiological roles of BACE2 and to determine whether BACE2 is the major beta-secretase in neurons, Johns Hopkins University researchers have created mice with targeted inactivation...

Published: 5/9/2024 | Inventor(s): Jonathan Yu, Donald Price, Philip Wong

Keywords(s): Alzheimer's Disease, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Neurodegeneration, Translational Research Biomarker

Beta-Secretase (BACE1) Polyclonal Antisera

C03929: Beta-Secretase (BACE1) Polyclonal Antisera Technical Details: To facilitate our understanding of the physiological role of BACE1 and its involvement in the generation of the Alzheimer?s disease (AD) Ab peptides, we generated a rabbit polyclonal antibody against BACE1. Our BACE1 antisera will be useful in the BACE1 levels and expression patterns...

Published: 5/9/2024 | Inventor(s): Huaibin Cai, Donald Price, Philip Wong

Keywords(s): Alzheimer's Disease, Antibodies, Biologics, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Geriatric Conditions, Neurodegeneration, Proteomics/Immunoassays, Proteomics/Immunoassays Antiserum, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Beta - Secretase (BACE1) Knockout Mice

C03774: Beta - Secretase (BACE1) Knockout Mice Technical Details: Two beta-secretases termed BACE1 and BACE2 have been shown to generate the Alzheimer's disease Abeta peptides. To examine the physiological roles of BACE1 and to determine whether BACE1 is the major beta-secretase in neurons, Johns Hopkins University researchers have created mice...

Published: 5/9/2024 | Inventor(s): Huaibin Cai, Donald Price, Philip Wong

Keywords(s): Alzheimer's Disease, Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Neurodegeneration

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