Search Results - denis+wirtz

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Phenotypic Microarray for Diagnosis of Cancer

Invention novelty: High Throughput Screening of pancreatic cancer cells by developing a phenotypic microarray Value Proposition: The market for cancer diagnostics is ever-expanding as the focus of global research on cancer reached its peak in the past five years. The use of microarrays as an ideal diagnostic tool for cancer detection is being realized...

Published: 5/9/2024 | Inventor(s): Denis Wirtz, Pei-Hsun Wu, Shyam Khatau, Wei-Chiang Chen, Zev Binder, Jude Phillip, Yiider Tseng

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Pharmakodynamic Biomarker, Prognostic Biomarker, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics, Technology Classifications > Research Tools > Assays

Multi-Compartment Fallopian Tube Organoid Model

Unmet Need: Existing organoid models of the fallopian tube are architecturally simplified compared to the intricate epithelial-lumen interface in scale and structure, and there remains a need in the art for multi-compartment fallopian tube organoids that architecturally simulate the intricate architecture of the epithelial-lumen interface in structural...

Published: 5/10/2024 | Inventor(s): Meng Horng Lee, Gabriella Russo, Denis Wirtz, Ashleigh Crawford, Wenxuan Du

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Medical Devices, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Research Stem Cells, Technology Classifications > Research Tools > Microfluidics, Clinical and Disease Specializations > Oncology

VR-Expressing Cells against Multiple Cytokines and Uses Thereof

Unmet Need· Recent technological breakthroughs have highlighted the therapeutic potential of immunotherapy (e.g., CAR-T cells) and have focused attention and efforts on developing safe and effective immunotherapy modalities.· Despite advances in the field, there remain several challenges to both efficacy and safety of CAR-T and other immunotherapies.· CAR-T...

Published: 5/10/2024 | Inventor(s): Adrian Johnston, Denis Wirtz

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Category(s): Technology Classifications > Therapeutic Modalities > Immunotherapies, Clinical and Disease Specializations > Immuno-Oncology

Computational method for the 3D reconstruction and multi-labelling of serially sectioned tissue

Unmet Need / Invention Novelty: Three-dimensional (3D) tissue reconstruction permits analyses of the relationships between cellular factors, tissue structure, and diseasepathology.Current methods used to visualize and quantify tissue structures in 3D space are limited to small volumes and have various constraints relating to consistency, information...

Published: 5/10/2024 | Inventor(s): Denis Wirtz, Ashley Kiemen, Pei-Hsun Wu, Ralph Hruban, Laura Wood, Alexandra Sneider, Luo Gu, Mehran Habibi, Joo Ho Kim

Keywords(s):

Category(s): Technology Classifications > Research Tools

Workflow for Targeted Analysis of Image Mass Cytometry

Technology Description· Researchers at Johns Hopkins have developed a streamlined workflow for performing targeted imaging in image mass cytometry (IMC) with improved region of interest (ROI) selection. · This approach for ROI identification uses adjacent stained sections (e.g., H&E, PAS) with more prominent tissue features as a guide.· ROI...

Published: 5/10/2024 | Inventor(s): Pei-Hsun Wu, Denis Wirtz, Won Jin Ho

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Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Imaging

Single-chain Knobs-in-holes Bispecific Antibody Construction

Unmet Need: In the United States, 40% of males and 38% of females will develop cancer in their lifetimes. Additionally, as of 2015, the annual direct medical costs of cancer stood at $80.2 billion. Targeted therapies, such as monoclonal antibody drugs, show great promise in cancer treatment, but these therapies still have many important limitations...

Published: 5/9/2024 | Inventor(s): Jamie Spangler, Denis Wirtz, Huilin Yang, Wentao Wang, Michelle Karl

Keywords(s): Antibodies, Discovery/Research Tools, Monoclonal Antibodies, Research Reagent, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies, Technology Classifications > Research Tools > Research Antibodies

Engineered Bispecific Antibodies for Targeted Inhibition of Tumor Metastasis

Description: Unmet Need. In the United States, 40% of males and 38% of females will develop cancer in their lifetimes. Many types of cancers, including triple negative breast cancer (TNBC) and pancreatic ductal adenocarcinoma (PDAC), have devastatingly low five year survival rates, even after the removal of primary tumors. Poor prognoses for these cancer...

Published: 5/9/2024 | Inventor(s): Jamie Spangler, Denis Wirtz, Huilin Yang, Wentao Wang, Michelle Karl

Keywords(s): Target, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies, Clinical and Disease Specializations > Oncology

Comprehensive Phenotyping Reveals Robust Determination to Cellular Biological Age

Technology OverviewJHU researchers have developed a platform to determine the cellular biological age of individuals based on quantifiable functional outputs of their cells. Using a comprehensive approach, of high-throughput single cell technologies to measure biochemical and biophysical properties of cells, we have further developed a generalized linear...

Published: 5/9/2024 | Inventor(s): Jude Phillip, Denis Wirtz, Pei-Hsun Wu, Jeremy Walston

Keywords(s): Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, In Vitro Research Tool, Physics, Research Instrument

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Research Tools