Search Results - jamie+spangler

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Engineered Cytokine-antibody Fusion for Targeted Expansion of Immune Effector Cells

Unmet NeedGlobal revenue from the cytokine therapeutics market was valued at approximately $16.5 billion in 2018, and cytokine immunotherapy is a promising field of anti-cancer treatments for a broad range of cancer types. In particular, interleukin-2 (IL-2) therapy is shown to stimulate anti-cancer immunity. However, IL-2 activates contradictory immune...

Published: 5/9/2024 | Inventor(s): Jamie Spangler, Jakub Tomala, Michael Leff, Seth Ludwig, Elissa Leonard, Marek Kovar, Jirina Kovarova

Keywords(s): Biologics, Cancers, Disease Indication, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Antibodies, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Biologics

Anti-Human IgG–Invertase Fusion Protein for Quantitative Immunosensing Using Glucometers

Unmet Need / Invention Novelty To mitigate the spread of infectious diseases, rapid and widely available testing methods are needed to screen immunity at the population scale. Current antibody quantification assays often require lab-based instrumentation and methodology that can only be used/followed by skilled personnel. Unfortunately, at-home tests...

Published: 5/10/2024 | Inventor(s): Jamie Spangler, Miguel Aller Pellitero, Boris Juelg, Netzahualcoyotl Arroyo, Elissa Leonard

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vivo Diagnostics

Engineered Tolerogenic Artificial Antigen-presenting Cells for Specific Expansion of Regulatory T Cells

Unmet NeedGlobal incidence of autoimmune disease is on the rise, and currently one in twelve Americans (including one in 9 women) suffer from autoimmune disease. Particularly, Type 1 Diabetes (T1D) represents a highly prevalent autoimmune disease, affecting over 20 million people. These diseases occur when the body’s immune system incorrectly attacks...

Published: 5/9/2024 | Inventor(s): Jordan Green, Jamie Spangler, Stephany Tzeng, Kelly Rhodes, Giorgio Raimondi, Marcos Iglesias Lozano, Jakub Tomala, Derek VanDyke, Randall Meyer

Keywords(s): Autoimmune Diseases, Biologics, Discovery/Research Tools, Disease Indication, Drug Delivery Vehicle, Inflammatory Disorders, Polymers, Recombinant Proteins, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Transplants

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Transplantation, Clinical and Disease Specializations > Diabetes > Type 1 Diabetes, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Cell Therapies

A Platform to Improve Metabolic Glycoengineering in Biomanufacturing

Unmet Need: Methods to control glycosylation, a critical post-translational modification of therapeutic proteins, now focus on maintaining conventional glycosylation profiles. Strict adherence to naturally-occurring glycosylation patterns, however, hinders and in some cases precludes the development of novel protein therapeutics required for rare diseases...

Published: 5/9/2024 | Inventor(s): Kevin Yarema, Christian Agatemor, Christopher Saeui, Matthew Buettner, Jamie Spangler, Seth Ludwig, Zachary Bernstein, Kris Dammen-Brower, Riddhima Deenar Chitre

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Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Industrial Tech

Platform for Population-Scale Screening of COVID-19 Antibodies

Unmet NeedCOVID-19 is a disease caused by the novel coronavirus SARS-CoV-2. As of September 2020, there are over 33 million cases of COVID-19 globally, resulting in 1 million deaths from the virus. Due to diverse individual responses to the virus and limited testing, it has been particularly hard to identify individuals that present no or mild symptoms...

Published: 5/10/2024 | Inventor(s): Netzahualcoyotl Arroyo, Jamie Spangler, Taekjip Ha, Elissa Leonard, Miguel Aller Pellitero, Soojung Hur, Harrison Khoo

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Category(s): Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Medical Devices, Technology Classifications > Diagnostics

Single-chain Knobs-in-holes Bispecific Antibody Construction

Unmet Need: In the United States, 40% of males and 38% of females will develop cancer in their lifetimes. Additionally, as of 2015, the annual direct medical costs of cancer stood at $80.2 billion. Targeted therapies, such as monoclonal antibody drugs, show great promise in cancer treatment, but these therapies still have many important limitations...

Published: 5/9/2024 | Inventor(s): Jamie Spangler, Denis Wirtz, Huilin Yang, Wentao Wang, Michelle Karl

Keywords(s): Antibodies, Discovery/Research Tools, Monoclonal Antibodies, Research Reagent, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies, Technology Classifications > Research Tools > Research Antibodies

Engineered Bispecific Antibodies for Targeted Inhibition of Tumor Metastasis

Description: Unmet Need. In the United States, 40% of males and 38% of females will develop cancer in their lifetimes. Many types of cancers, including triple negative breast cancer (TNBC) and pancreatic ductal adenocarcinoma (PDAC), have devastatingly low five year survival rates, even after the removal of primary tumors. Poor prognoses for these cancer...

Published: 5/9/2024 | Inventor(s): Jamie Spangler, Denis Wirtz, Huilin Yang, Wentao Wang, Michelle Karl

Keywords(s): Target, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies, Clinical and Disease Specializations > Oncology