Search Results - david+graham

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Unmet Need: Viral infections in humans, animals, plants and insects lead to many societal burdens including disease and agricultural loss. Most anti-viral treatment strategies to date are limited in scope to the virus of interest and often result in drug resistance, incomplete efficacy, and/or toxicity. Costs for viral specific targets can be massive...

Published: 5/9/2024 | Inventor(s): Upinder Singh, Scott Grecian, Brian Agnew, David Graham

Keywords(s): Antagonists/Inhibitors, Disease Indication, Drug Delivery Mechanism, Infectious Diseases, Oral Administration, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Multiplex Mass Spectrometry Assay on a Pentaflouropropyl (PFPP) Stationary Phase

Dried blood spot (DBS) tests are an important diagnostic tool used for newborns. Unfortunately DBS has a variety limitations. According to the CDC, approximately four million DBS tests are required for infants are born in the United States each year. Conventional newborn screening with DBS begins with the addition of capillary blood droplets from a...

Published: 5/10/2024 | Inventor(s): David Graham, Aurelie Roux, Robert Harlan

Keywords(s):

Category(s): Clinical and Disease Specializations > Hematology, Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Research Tools > Blood & Tissue Samples, Technology Classifications > Diagnostics

OMICS Integrator: A Bioinformatics Pipeline to Integrate and Interpret Multi Omics Data

The major bottleneck of proteomics is no longer the ability to generate data, but the correct analysis of proteomics data, and mining as much information from it as possible. This new software allows us to rapidly analyze data generated by mass spectrometry in an extensive maner using advanced charge state determination of MS spectra, search spectra...

Published: 5/9/2024 | Inventor(s): Gerhard Thallinger, Juergen Hartler, Nathan Edwards, David Graham, Rhoel David Dinglasan, Ravi Tharakan, Ceereena Ubaida Mohien

Keywords(s): Computer and Network Systems, Computer Software, Computing; Calculating; Counting, Database Management Software, Electrical Digital Data Processing, Physics

Category(s): Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Algorithms

A Novel Method for Unambiguous, Quantitative Detection of Full-length and Truncated Thioredoxin from Complex Biological Samples

Unmet Need: Thioredoxin (TRX) is an essential protein that acts as antioxidant and can be used as a general marker of many different disease conditions involving oxidative stress. Currently, the level of thioredoxin is detected using ELISA methods. While potentially informative, there may be several problems inherent in this technique as this protein...

Published: 5/9/2024 | Inventor(s): Mary Zink, Susan Trow-Follstaedt, David Graham

Keywords(s): Assay, Basic Research Biomarker, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics, Peptides, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Assays

Development of Peptide Antibody Depletion (PAD) and its Application to Mass Spectrometry Sample Preparation

C04975: Development of Peptide Antibody Depletion (PAD) and its Application to Mass Spectrometry Sample Preparation Technical Details: One of the major limitations of mass spectrometry is obtaining mass information on proteins in the presence of contaminating materials or other high abundant proteins that, when present in the sample, suppress the...

Published: 5/9/2024 | Inventor(s): David Graham, Rebekah Gundry, Jennifer Van Eyk

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Research Instrument

Category(s): Technology Classifications > Research Tools