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Discovery of 2,6-Dimethoxy-4-(5-Phenyl-4-Thiophen-2-yl-1H-Imidazol-2-yl)-Phenol (DPTIP) a Small Molecule Inhibitor of Neutral Sphingomyelinase 2 (nSMase2) for the Treatment of Neurodegenerative and Oncologic Diseases

Unmet NeedAlzheimer’s disease (AD) is the most common form of dementia, affecting approximately 5.7 million people in the United States in 2018. Yet, no cure exists for AD, and AD therapeutics presently on the market fail to treat the disease’s underlying causes. Recent studies in mice reveal that exosomes released from glial cells contribute to the...

Published: 5/9/2024 | Inventor(s): Barbara Slusher, Camilo Rojas, Ajit Thomas, Norman Haughey, Marc Ferrer, Xin Hu

Keywords(s): Antagonists/Inhibitors, Cancers, CNS and Neurological Disorders, Disease Indication, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules

Emetine for Inhibition of Human Cytomegalovirus (HCMV)

UNMET NEED: Infection with human cytomegalovirus (HCMV) continues to be a major threat for pregnant women and immunocompromised hosts. Although anti-HCMV therapies are available, development of new agents are desired because of the limited drugs approved for HCMV, the side effects associated with them, and the emergence of resistant viral mutants during...

Published: 5/9/2024 | Inventor(s): Ravit Boger, Marc Ferrer, Juan Marugan, Andres Garcia, Noel Southall, Xin Hu

Keywords(s): Antagonists/Inhibitors, Cytomegalovirus, Disease Indication, Infectious Diseases, Non-novel, Off-the-shelf, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Cytomegalovirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities