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Novel Inhibitors of Toll Like Receptor 4 for the Prevention and Treatment of Inflammatory Disorders

Unmet Need / Invention Novelty: TLR4 (Toll-like receptor 4) is the most upstream receptor in the pro-inflammatory cascade for endotoxin lipopolysaccharide (LPS). While normally downregulated gradually after full-term birth, high levels of TLR4 expression in infants born prematurely is associated with the development of NEC (necrotizing enterocolitis),...

Published: 3/14/2025 | Inventor(s): David Hackam, Peng Lu, Chhinder Sodhi, Peter Wipf, Adam Montoya

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Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Inflammation > Necrotizing Enterocolitis, Clinical and Disease Specializations > Pediatrics