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Induction of Synthetic Lethality with Epigenetic Therapy (ISLET) by Combined DNA Methyltransferase and Aurora Kinase Inhibition

Invention NoveltyThis invention is a novel paradigm for the induction of synthetic lethality through epigenetic modulations. This can induce functionality and efficacy of therapeutics against cancer cells that may have resistance to each therapeutic alone. Value PropositionThe complex and adaptive nature of the host of diseases termed cancer poses significant...

Published: 9/26/2024 | Inventor(s): Srinivasan Yegnasubramanian, William Nelson, Ajay Vaghasia, Philipp Nuhn

Keywords(s): Cancers, Chemotherapy/Targeted Therapy, Combination, Disease Indication, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities