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Particulate Drug Delivery System to Enable Targeted Ultrasound-gated Release of Neuromodulatory Agents

Targeted, noninvasive neuromodulation of the brain of an otherwise awake subject could revolutionize both basic and clinical neuroscience. Towards this goal, the JHU scientists have developed nanoparticles that allow noninvasive uncaging of a neuromodulatory drug upon the application of focused ultrasound. These nanoparticles are composed of biodegradable...

Published: 7/24/2026 | Inventor(s): Jordan Green, Raag Airan, Randall Meyer

Keywords(s): CNS and Neurological Disorders, Disease Indication, Drug Delivery Mechanism, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Nerve Disorders and Injury, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices > Neurostimulation

Quantitative HIV diagnostic that detects mutational burden

Value PropositionStraightforward and scalable: Researchers at Johns Hopkins have created a diagnostic assay that can quantify viral HIV particles in plasma and, at the same time, predict whether they are replication competent.Sensitive and low cost: This diagnostic tool can detect low levels of viremia and distinguish single mutations without the need...

Published: 7/24/2026 | Inventor(s): Francesco Simonetti

Keywords(s):

Category(s): Clinical and Disease Specializations > Research Tools > Assays, Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > HIV, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS

FlowMate Device

Value Proposition:· Easier dose release activation, leading to enhanced dry powder dose delivery in pediatric patients.· Cost-efficient attachment utilizing a magnetic system that is less vulnerable to mechanical failure. · Built-in visual and auditory feedback mechanism to confirm system actuation.Technology Description· Researchers...

Published: 7/24/2026 | Inventor(s): Mandeep Jassal, Lily Zhu, Yunong Bai, Isaree Pitaktong, Punthitra Arpornsuksant, Damali Egyen-Davis, Varun Kedia, Colin Lee, George Coles, Carlton Lee, Maxwell Xu, Aditya Khandeshi

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases > Asthma, Clinical and Disease Specializations > Respiratory Diseases > Chronic Obstructive Pulmonary Disorder, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Therapeutic Devices

Sutureless Adhesive Connectors for Tissue Repair

Value Proposition· Eliminates the need for time-consuming microsurgical sutures for tubular organ repair, reducing operative time and anesthesia exposure.· Minimizes additional tissue trauma caused by suturing, improving functional recovery and reducing complications.· Uses biodegradable materials and engineered adhesives/nanostructures...

Published: 7/23/2026 | Inventor(s): Hai-Quan Mao, Ahmet Hoke

Keywords(s): Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

Same‑Day Antibiotic Susceptibility Screening

Value Proposition· Faster, same‑day guidance for prescribing antibiotics: Rapid bedside screening platform that captures cultures and tests bacteria from clinical specimens (e.g., urine) to inform immediate antibiotics prescribing in doctors’ offices, urgent care, and outpatient clinics.· Useful for low‑volume infections: Because the system...

Published: 7/24/2026 | Inventor(s): Andrew Feldman, Hannah Gray, Jeffrey Lin, Charles Young

Keywords(s): Bacterial Infections, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Point of Care

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Precision Medicine Tools, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Applied Physics Laboratory > Applied Physics Laboratory

Non-surgical treatment for corneal blindness

Value Proposition· Non-surgical, non-invasive treatment for loss of vision caused by corneal damage.· Cost effective to manufacture· Easy application· Regenerates existing cornea structure to restore vision.Unmet NeedThe only curative option for many cases of corneal blindness remains surgical corneal transplantation, a resource‑intensive...

Published: 7/24/2026 | Inventor(s): Kannan Rangaramanujam, Samuel Yiu, Minjie Chen, Siva Pramodh Kambhampati, Hui Lin

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ophthalmology, Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy, Clinical and Disease Specializations > Ophthalmology > Corneal Neovascularization, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

MRGPRX4 Targeted Therapeutics and Research Tools for Melanoma Diagnosis, Modeling, and Treatment

Unmet NeedMelanoma incidence continues to rise sharply, and current therapies remain inadequate for many patient populations, especially those lacking drug‑targetable mutations such as BRAF. A major limitation in melanoma research and drug discovery is the absence of models and targets that reflect the biology of non‑BRAF‑driven melanoma. Recent findings...

Published: 7/24/2026 | Inventor(s): Xinzhong Dong, Naina Gour

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Melanoma, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Dermatology

Use of Non-labeled Sugars in MRI

Value Proposition: ADVANTAGES: • Provides an alternative approach to measure MR contrast sensitive to both metabolic and vascular properties (perfusion and permeability) of tissue. • Uses a natural biodegradable compound that is already available in the clinic, without the need for paramagnetic, magnetic, or radioactive isotope labeling....

Published: 7/23/2026 | Inventor(s): Guanshu Liu, Dmitri Artemov, Yoshinori Kato, Kannie Chan, Michael Mcmahon, Peter van Zijl

Keywords(s): Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices

Novel HPV Vaccine

Value Proposition: • A broadly protective vaccine against HPV. • Can be delivered without needles. • Can be chemically synthesized at low cost. Technical Details: Human papillomavirus (HPV) infections are the most common sexually transmitted infection in the United States. Infection by over 15 different oncogenic HPV genotypes is a cause of...

Published: 7/23/2026 | Inventor(s): Hannah Alphs-Jackson, Ratish Gambhira, Richard Roden

Keywords(s): Biologics, Cancers, Disease Indication, Therapeutic Matter, Therapeutic Substance, Therapeutics, Vaccine

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Therapeutic Modalities

Leucine-Rich Repeat Kinase 2 (LRRK2) cDNA Vectors Research Reagent

Studies have shown that mutations in the LRRK2 gene are the most common determinants of late-onset Parkinsons disease (PD) susceptibility. These cDNA vectors comprise wild type LRRK2 cDNA or mutated LRRK2 cDNA that can be expressed in cells to decipher the biochemical pathways and pathology of PD. Other advantages include:• Produced from human source...

Published: 7/23/2026 | Inventor(s): Ted Dawson

Keywords(s): Basic Research Biomarker, Cloning Reagents, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Nucleotide, Parkinson's Disease, Research Reagent

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Parkinson's Disease

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