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Compositions and Biomarkers for Human Cancer and Methods of Use

Novel biomarkers for the detection and prognosis of several cancersJHU REF: C12506 Invention novelty: This invention has discovered high frequency mutations in the telomerase reverse transcriptase (TERT) promoter of certain cancers. Value Proposition: Early detection is usually critical for the successful treatment of cancer, therefore there is...

Published: 6/26/2025 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Chetan Bettegowda, Yuchen Jiao, Darell Bigner, Hai Yan, Zachary Reitman, Patrick Killela

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Predictive Algorithms for MISKD Clinical Decision Support System

Unmet NeedChildren hospitalized with SARS-Cov-2 infection are at risk for two similar inflammatory syndromes: Kawasaki disease (KD), and multi-system inflammatory syndrome in children (MIS-C). However, current clinical diagnostic standards for these two conditions have considerable overlap, which can lead to misdiagnosis and suboptimal treatment and...

Published: 6/27/2025 | Inventor(s): Cedric Manlhiot, Bhargava Kumar Chinni, Shelby Kutty

Keywords(s):

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Clinical and Disease Specializations > Infectious Diseases > Covid-19, Clinical and Disease Specializations > Inflammation

Manipulation of Regulatory T Cell and DC Function by Targeting Neuritin Gene Using Antibodies, Agonists and Antagonists

Unmet NeedThe recent breakthroughs in immuno-oncology have changed the way that researchers think about treating autoimmune diseases and cancer by modulating the immune system. Regulatory T cells (Treg) limit autoimmunity but also attenuate the potency of antitumor immunity. Enhancement of Treg function could treat autoimmune diseases while the inhibition...

Published: 6/26/2025 | Inventor(s): Drew Pardoll, Joseph Barbi, Fan Pan, Hong Yu, Ching-Tai Huang, Xiaoyu Pan, Charles Drake, Jonathan Powell

Keywords(s): Antibodies, Biologics, Cancers, Disease Indication, Immunotherapy, Infectious Diseases, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics

Therapeutic KCNK9 Antibody

Value PropositionFirst-in-Class Targeting of a Novel Oncogenic Ion Channel: Inhibiting KCNK9 represents a new therapeutic modality in cancers where traditional approachesTumor-Specific Overexpression Enables Selectivity: KCNK9 is overexpressed in various tumors (e.g., breast, gastric, lung) but has limited expression in most normal tissuesPro-Apoptotic...

Published: 6/27/2025 | Inventor(s): John Laterra, Amy Fulton

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Lung Cancer, Clinical and Disease Specializations > Oncology > Gastric Cancer, Technology Classifications > Therapeutic Modalities > Antibodies

Novel monoclonal antibody inhibitors targeting potassium channel KCNK9

Unmet Need:KCNK9 is one of 15 mammalian subtypes in the highly conserved family of two-pore domain potassium channels (K2P). Under physiological conditions, KCNK9 is primarily expressed in the brain where it serves to maintain cellular membrane potentials. However, overexpression of KCNK9 has been detected in breast, lung, skin, and other cancers, and...

Published: 6/26/2025 | Inventor(s): John Laterra, Han Sun, Min Li, Amy Fulton

Keywords(s): Antibodies, Biologics, Breast Cancer, Cancers, Disease Indication, Lung Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Women's Health, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Lung Cancer

Targeted Antineoplastic Therapeutic for Cancers with High Translation Rates

Value Proposition:Targeted cancer therapeutic and combination therapy to prevent resistanceTarget cancer cell’s vulnerable translation processesTarget aggressive cancers with poor prognoses at present Technology DescriptionThe disclosed technology addresses the major challenge of identifying selective drug therapies that kill cancer cells, without affecting...

Published: 6/27/2025 | Inventor(s): Rachel Green, Sergi Regot, Niladri Sinha, Connor McKenney

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Method and System for the Early Detection of Acute Kidney Injury

Acute kidney injury (AKI) is a condition where the kidneys become unable to adequately filter the blood, causing toxic levels of waste to accumulate throughout the body. AKI is formally defined as a “>50% decrease in glomerular filtration rate (GFR) over a period of hours to days,” which leads to a decline in urine output over time. Measuring urine...

Published: 6/26/2025 | Inventor(s): Aaron Chang, Alexandra Sibole, Sriram Chadalavada, Madeleine Clegg, Patience Osei, Nevin Katz, Jonathan Magruder

Keywords(s): Clinical Diagnostics, Diagnostic Tool, Disease Indication, Kidney Disorders, Measurement Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Nephrology, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Diagnostics

Novel Proteins for Diagnosis and Treatment of Acute Kidney Injury

Novel Proteins for Diagnosis and Treatment of Acute Kidney Injury (AKI)JHU Ref #: C17069 Value PropositionInvention provides compositions and methods useful for the diagnosis and treatment of acute kidney injury (AKI)Demonstrates the feasibility of using a multiomics approach to discover novel, noninvasive markers of AKI that are associated with adverse...

Published: 6/27/2025 | Inventor(s): Chirag Parikh, Yumeng Wen

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Diagnostics, Clinical and Disease Specializations, Clinical and Disease Specializations > Nephrology

Innovative Suit Designs and Doffing Methodologies for Personal Protective Equipment to prevent the spread of Ebola to Health Care Workers

Value Proposition· Increased safety: features back seam entry and exit with integrated doffing and disposal methods to reduce risk of contamination.· Easy to use: Simplified doffing decreases the complexity and time required to doff PPE.· Customizable and comfortable: Design includes sizing adjustments, sweat-wicking features, and...

Published: 6/30/2025 | Inventor(s): Youseph Yazdi, Melody Tan, Matthew Petney, William Patterson, Siavash Parkhideh, Jill Andrews, Patience Osei, Chandrakant Ruparelia, Harshadkumar Sanghvi, Timothy Harrigan, Nahyun Cho, Qian Liu, Sami Messai, Brian Ma, Meagan Hawes, Reeve Heinis, Jason Johnson, Erin Reisfeld, Arjun Vachhani, Timothy Campbell, Neil Rens, Madeleine Clegg, Elizabeth Stokley, Jessica Jeang, Christopher Chiang, Willibrord Shasha, Bailey Topper, Kimberly Ashman, Michael Parlato, Brandon Craft, Paul Fearis, Soumyadipta Acharya

Keywords(s): Disease Indication, Ebola, Industrial Manufacturing, Infectious Diseases, Manufactured Devices, Personal Protective Equipment (PPE), Safety Suits, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Industrial Tech, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Ebola, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Engineering Tech > Industrial Manufacturing

Patient-specific simulation guidance of infarct-related ventricular ablation and cardiac resynchronization therapy

Value Proposition· Non-invasive: MRI-based computational modeling provides guidance for catheter-based ablation or LV electrode placement in the treatment of hear disease.· Personalized: Predicts location of optimal ablation or LV electrode placement for each patient.Unmet Need· Ventricular tachycardia (VT) in the setting of myocardial...

Published: 6/26/2025 | Inventor(s): Natalia Trayanova, Henry Halperin, Jason Constantino, Hermenegild Arevalo

Keywords(s): Cardiovascular Diseases, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Disease Indication, Physics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Computers, Electronics & Software

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