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System and Method for Antimicrobial Drug Susceptibility Screening at the Bedside

Value Proposition· Faster, same‑day guidance for prescribing antibiotics: Rapid bedside screening platform that captures cultures and tests bacteria from clinical specimens (e.g., urine) to inform immediate antibiotics prescribing in doctors’ offices, urgent care, and outpatient clinics.· Useful for low‑volume infections: Because the system...

Published: 3/13/2026 | Inventor(s): Andrew Feldman, Hannah Gray, Jeffrey Lin, Charles Young

Keywords(s): Bacterial Infections, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Point of Care

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Precision Medicine Tools, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Applied Physics Laboratory > Applied Physics Laboratory

bio-IB3

Unmet NeedAccording to the CDC, approximately 5.8-million individuals aged 65+ in the United States were living with Alzheimer’s disease in 2020 (see CDC). Alzheimer’s disease leads to memory impairment that progressively affects the ability of individuals to conduct daily tasks and worsens with time. Currently, the diagnosis of Alzheimer’s disease...

Published: 3/12/2026 | Inventor(s): Esther Oh, Stina Tucker, David Borchelt, Juan Troncoso

Keywords(s): Alzheimer's Disease, Antibodies, Biologics, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Neurodegeneration, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration

Non-surgical treatment for corneal blindness

Value Proposition· Non-surgical, non-invasive treatment for loss of vision caused by corneal damage.· Cost effective to manufacture· Easy application· Regenerates existing cornea structure to restore vision.Unmet NeedThe only curative option for many cases of corneal blindness remains surgical corneal transplantation, a resource‑intensive...

Published: 3/13/2026 | Inventor(s): Kannan Rangaramanujam, Samuel Yiu, Minjie Chen, Siva Pramodh Kambhampati, Hui Lin

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ophthalmology, Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy, Clinical and Disease Specializations > Ophthalmology > Corneal Neovascularization, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

MRGPRX4 Targeted Therapeutics and Research Tools for Melanoma Diagnosis, Modeling, and Treatment

Unmet NeedMelanoma incidence continues to rise sharply, and current therapies remain inadequate for many patient populations, especially those lacking drug‑targetable mutations such as BRAF. A major limitation in melanoma research and drug discovery is the absence of models and targets that reflect the biology of non‑BRAF‑driven melanoma. Recent findings...

Published: 3/13/2026 | Inventor(s): Xinzhong Dong, Naina Gour

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Melanoma, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Dermatology

Use of Non-labeled Sugars in MRI

Value Proposition: ADVANTAGES: • Provides an alternative approach to measure MR contrast sensitive to both metabolic and vascular properties (perfusion and permeability) of tissue. • Uses a natural biodegradable compound that is already available in the clinic, without the need for paramagnetic, magnetic, or radioactive isotope labeling....

Published: 3/12/2026 | Inventor(s): Guanshu Liu, Dmitri Artemov, Yoshinori Kato, Kannie Chan, Michael Mcmahon, Peter van Zijl

Keywords(s): Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices

L2 Lipopeptide Vaccine for Prevention of Human Papillomavirus Infection

C10218: L2 Lipopeptide Vaccine for Prevention of Human Papillomavirus Infection Value Proposition: • A broadly protective vaccine against HPV. • Can be delivered without needles. • Can be chemically synthesized at low cost. Technical Details: Human papillomavirus (HPV) infections are the most common sexually transmitted infection in the...

Published: 3/12/2026 | Inventor(s): Hannah Alphs-Jackson, Ratish Gambhira, Richard Roden

Keywords(s): Biologics, Cancers, Disease Indication, Therapeutic Matter, Therapeutic Substance, Therapeutics, Vaccine

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Therapeutic Modalities

Human LRRK2 cDNA

Studies have shown that mutations in the LRRK2 gene are the most common determinants of late-onset Parkinsons disease (PD) susceptibility. These cDNA vectors comprise wild type LRRK2 cDNA or mutated LRRK2 cDNA that can be expressed in cells to decipher the biochemical pathways and pathology of PD. Other advantages include:• Produced from human source...

Published: 3/12/2026 | Inventor(s): Ted Dawson

Keywords(s): Basic Research Biomarker, Cloning Reagents, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Nucleotide, Parkinson's Disease, Research Reagent

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Parkinson's Disease

Biomimetic Platforms to Model Vascular Pathophysiology, Diagnostics, and Therapy

Value Proposition· Biomimetic platform of human pulmonary arterioles that enables researchers and clinicians to better understand pulmonary hypertension.· Precisely engineered, tunable, functional, and anatomically accurate biomimetic human pulmonary microvasculature supports quantitative analysis of endothelial and smooth muscle cell...

Published: 3/12/2026 | Inventor(s): Lewis Romer, David Gracias, Jayson Pagaduan, Anil Bhatta, Xing Chen, Qianru Jin

Keywords(s): Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Lung Disorders, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

Patient-specific Trackable Cutting Guides

Value Proposition· Novel Mechanism: Bone-anchored guide with an attachment device, an integrated cut-location indicator, and an adjustable arm-support that carries a trackable feature.· Disease-Modifying Potential: Increases cut accuracy, reducing malalignment, lowering revision risk, and preserving bone stock through precisely guided resections.· Broad...

Published: 3/12/2026 | Inventor(s): Mehran Armand, Gerald Grant, Peter Liacouras, Ryan Murphy, Chad Gordon

Keywords(s): Interventional and Surgical Systems, Surgical Navigation

Category(s): Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices, Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal > Osteoporosis, Applied Physics Laboratory > Applied Physics Laboratory

Targeting of Myeloid-Derived Suppressor Cells (MDSCs) for Cancer Treatment

Value Proposition· Addresses key resistance mechanism: targets MDSCs, a central driver of resistance to immune checkpoint inhibitors in metastatic and poorly immunogenic cancers· Synergistic combination strategy: Combines epigenetic modulators (HDAC and DNA methyltransferase inhibitors) with anti-PD-1 and anti-CTLA-4 antibodies to restore...

Published: 3/12/2026 | Inventor(s): KiBem Kim, Bert Vogelstein, Kenneth Kinzler, Shibin Zhou

Keywords(s): Antagonists/Inhibitors, Antibodies, Biologics, Cancers, Combination, Disease Indication, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Targeted Therapy/Immunotherapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

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