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Search Results - antibodies
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A Novel and Unique Set of Human
Antibodies
to Human Resistin and to Human Resitin-like Molecule Beta (RELMB) that can be used to Target these Proteins in Human Disease
Unmet NeedAutoinflammatory responses, your body’s innate defense mechanism against infections and stressors, can become overactive and cause chronic inflammation in various tissues and organs. Inflammatory diseases affect more than 200 million people worldwide and include pulmonary hypertension, scleroderma, rheumatoid arthritis, pulmonary fibrosis,...
Published: 3/13/2025
|
Inventor(s):
Roger Johns
Keywords(s):
Antibodies
,
Biologics
,
Cardiovascular Diseases
,
Disease Indication
,
Hypertension
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Clinical and Disease Specializations
,
Technology Classifications > Therapeutic Modalities >
Antibodies
,
Technology Classifications > Therapeutic Modalities > Biologics
,
Clinical and Disease Specializations > Cardiovascular
,
Technology Classifications > Therapeutic Modalities
,
Clinical and Disease Specializations > Cardiovascular > Hypertension
Hybridoma expressing anti-RG-1 mAb for the study of human papillomavirus L2
Technology DescriptionJHU scientists generated a hybridoma expressing a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising conserved residues neutralized pseudoviruses HPV5,...
Published: 3/13/2025
|
Inventor(s):
Ratish Gambhira
,
Richard Roden
Keywords(s):
Antibodies
,
Basic Research Biomarker
,
Cell Model
,
Discovery/Research Tools
,
Hybridomas
,
In Vitro Research Tool
,
Monoclonal
Antibodies
,
Research Reagent
Category(s):
Technology Classifications > Research Tools >
Antibodies
,
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools
Highly Specific Monoclonal
Antibodies
used as Allosteric Inhibitors and Specific Biosensors of Human ZnT8
Unmet NeedType 2 diabetes (T2D) is a growing worldwide public health issue affecting over 500 million people while creating a $1 trillion economic burden on global healthcare economies. Many current and new therapeutics demonstrate varying degrees of effectiveness, but no single agent or combination thereof has been able to provide patients with lasting...
Published: 3/14/2025
|
Inventor(s):
Dax Fu
,
Chengfeng Merriman
Keywords(s):
Antibodies
,
Biologics
,
Diabetes
,
Discovery/Research Tools
,
Disease Indication
,
Metabolic Disorders
,
Monoclonal
Antibodies
,
Research Reagent
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
,
Translational Research Biomarker
,
Type II Diabetes
Category(s):
Technology Classifications > Research Tools > Research
Antibodies
,
Clinical and Disease Specializations > Diabetes > Type 2 Diabetes
,
Technology Classifications > Therapeutic Modalities > Therapeutic
Antibodies
Rapid Assay for Carcinoma Stem Cells
Unmet NeedWhile cancer therapeutics have drastically improved patient outcomes in numerous indications, novel methods to prevent cancer metastasis and recurrence are needed. Cancer stem cells (CSCs) are a unique subpopulation of a tumor that are more oncogenic and slow-growing than other cancer cells within the tumor. CSCs make up approximately .1-10%...
Published: 3/13/2025
|
Inventor(s):
William Matsui
,
Xiaobing He
,
David Berman
Keywords(s):
Antibodies
,
Biologics
,
Bladder Cancer
,
Cancers
,
Disease Indication
,
Immunotherapy
,
Single
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
,
Therapy Type
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Urology
,
Technology Classifications > Therapeutic Modalities >
Antibodies
,
Technology Classifications > Therapeutic Modalities > Biologics
,
Technology Classifications > Therapeutic Modalities > Immunotherapies
,
Technology Classifications > Therapeutic Modalities
,
Clinical and Disease Specializations > Oncology
,
Clinical and Disease Specializations > Oncology > Bladder Cancer
Neuritin Impact T Cell Tolerance Induction and Maintenance and is a Target for Tumor Immunotherapy
Unmet NeedCancer immunotherapy is a therapeutic approach that has revolutionized advanced cancer treatment. In particular, the use of therapeutic blocking
antibodies
to cytotoxic T-lymphocyte antigen 4 (CTLA4) and programmed cell death protein (PD-1) has achieved routine clinical use in numerous indications. Despite these promising results, monotherapy...
Published: 3/14/2025
|
Inventor(s):
Drew Pardoll
,
Hong Yu
,
Joseph Barbi
,
Fan Pan
,
Charles Drake
Keywords(s):
Antibodies
,
Autoimmune Diseases
,
Biologics
,
Cancers
,
Combination
,
Disease Indication
,
Inflammatory Disorders
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
,
Therapy Type
Category(s):
Clinical and Disease Specializations > Autoimmunity
,
Clinical and Disease Specializations > Oncology
,
Technology Classifications > Therapeutic Modalities > Biologics
,
Technology Classifications > Therapeutic Modalities > Immunotherapies
,
Technology Classifications > Therapeutic Modalities > Therapeutic
Antibodies
Screening Method to Identify Scleroderma Immune Responses with Anti-cancer Activity, and Induction of such Immune Responses for Cancer Therapy
Unmet NeedEpidemiological studies have shown that patients with scleroderma, a type of autoimmune rheumatic disease affecting the skin and connective tissues, have an increased risk of developing cancer relative to the general population. The exact etiology of scleroderma is still unknown. The Scleroderma Foundation estimates about 100,000 to 300,000...
Published: 3/13/2025
|
Inventor(s):
Ami Shah
,
Livia Casciola-Rosen
,
Antony Rosen
,
Takeru Igusa
,
Marikki Laiho
Keywords(s):
Antibodies
,
Autoimmune Diseases
,
Biologics
,
Biomarker
,
Cancers
,
Clinical Diagnostics
,
Diagnostic Biomarker
,
Disease Indication
,
In Vitro Diagnostics
,
Inflammatory Disorders
,
Risk Stratification
,
Scleroderma
,
Skin Disorders
,
Skin Fibrosis
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Oncology
,
Clinical and Disease Specializations > Autoimmunity
,
Clinical and Disease Specializations > Fibrosis
,
Clinical and Disease Specializations > Rare Diseases
,
Clinical and Disease Specializations > Inflammation
,
Clinical and Disease Specializations > Immunology
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools
,
Technology Classifications > Diagnostics > Diagnostic Biomarkers
,
Technology Classifications > Therapeutic Modalities > Biologics
,
Technology Classifications > Therapeutic Modalities >
Antibodies
,
Technology Classifications > Therapeutic Modalities > Targets
,
Technology Classifications > Computers, Electronics & Software
,
Clinical and Disease Specializations > Dermatology
,
Technology Classifications > Diagnostics
,
Technology Classifications > Therapeutic Modalities
,
Clinical and Disease Specializations > Dermatology > Scleroderma
Antibodies
to Visual Pigment Proteins, Transcription Factor Sox17, and Multimerized Epitope Tags
Unmet Need:Canonical Wnt signaling is one of the major pathways involved in embryonic development and tissue regeneration. Recent studies suggest that canonical Wnt signaling is vital for brain angiogenesis and the acquisition of barrier properties by the microvasculature. There is a need in the field for the development of reagents that allow for the...
Published: 3/14/2025
|
Inventor(s):
Jeremy Nathans
Keywords(s):
Antibodies
,
Discovery/Research Tools
,
Labels/Markers
,
Monoclonal
Antibodies
,
Research Reagent
Category(s):
Technology Classifications > Research Tools > Proteins, Ligands & Receptors
,
Technology Classifications > Research Tools > Research
Antibodies
Single-chain Knobs-in-holes Bispecific Antibody Construction
Unmet Need: In the United States, 40% of males and 38% of females will develop cancer in their lifetimes. Additionally, as of 2015, the annual direct medical costs of cancer stood at $80.2 billion. Targeted therapies, such as monoclonal antibody drugs, show great promise in cancer treatment, but these therapies still have many important limitations...
Published: 3/14/2025
|
Inventor(s):
Jamie Spangler
,
Denis Wirtz
,
Huilin Yang
,
Wentao Wang
,
Michelle Karl
Keywords(s):
Antibodies
,
Discovery/Research Tools
,
Monoclonal
Antibodies
,
Research Reagent
,
Therapeutic Matter
,
Therapeutic Substance Synthesis Method
,
Therapeutics
Category(s):
Technology Classifications > Therapeutic Modalities > Therapeutic
Antibodies
,
Technology Classifications > Research Tools > Research
Antibodies
Human Stem Cells and Monoclonal
Antibodies
(MY-10)
Human Stem Cells and Monoclonal
Antibodies
(MY-10) Case Number C02182 ABSTRACT Monoclonal antibodies that recognize a stage-specific antigen on immature human marrow cells. These antibodies are useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marrow transplantation. Cell suspensions containing...
Published: 3/13/2025
|
Inventor(s):
Curt Civin
Keywords(s):
Antibodies
,
Biologics
,
Bone Marrow
,
Bone Marrow Transplant
,
Cell Therapy
,
Disease Indication
,
Single
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
,
Therapy Type
,
Transplants
Category(s):
Clinical and Disease Specializations
,
Technology Classifications > Therapeutic Modalities >
Antibodies
,
Technology Classifications > Therapeutic Modalities > Biologics
,
Technology Classifications > Therapeutic Modalities > Cell Therapies
,
Technology Classifications > Therapeutic Modalities
,
Clinical and Disease Specializations > Transplantation
,
Clinical and Disease Specializations > Transplantation > Bone Marrow Transplant
Manipulation of Regulatory T Cell and DC Function by Targeting Neuritin Gene Using
Antibodies
, Agonists and Antagonists
Unmet NeedThe recent breakthroughs in immuno-oncology have changed the way that researchers think about treating autoimmune diseases and cancer by modulating the immune system. Regulatory T cells (Treg) limit autoimmunity but also attenuate the potency of antitumor immunity. Enhancement of Treg function could treat autoimmune diseases while the inhibition...
Published: 3/13/2025
|
Inventor(s):
Drew Pardoll
,
Joseph Barbi
,
Fan Pan
,
Hong Yu
,
Ching-Tai Huang
,
Xiaoyu Pan
,
Charles Drake
,
Jonathan Powell
Keywords(s):
Antibodies
,
Biologics
,
Cancers
,
Disease Indication
,
Immunotherapy
,
Infectious Diseases
,
Single
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
,
Therapy Type
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Infectious Diseases
,
Clinical and Disease Specializations > Oncology
,
Technology Classifications > Therapeutic Modalities > Immunotherapies
,
Technology Classifications > Therapeutic Modalities
,
Technology Classifications > Therapeutic Modalities >
Antibodies
,
Technology Classifications > Therapeutic Modalities > Biologics
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