Search Results - monoclonal+antibodies

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Antibodies that Enhance PAD4 Activity for the Study of Autoimmune Diseases

Value Proposition· Enhanced Research Capabilities: Provides five distinct human monoclonal antibodies that enhance PAD4 activity for in vitro and in vivo experimental assays, enabling researchers to study PAD4's function in autoimmune diseases such as rheumatoid arthritis.· Scalable Production: Utilizes commercially available immortalized...

Published: 7/24/2026 | Inventor(s): Felipe Andrade, Jing Shi, Antony Rosen, Erika Darrah

Keywords(s): Antibodies, Autoimmune Diseases, Basic Research Biomarker, Discovery/Research Tools, Disease Indication, Inflammatory Disorders, Monoclonal Antibodies, Research Reagent

Category(s): Clinical and Disease Specializations > Autoimmunity, Technology Classifications > Diagnostics, Technology Classifications > Research Tools > Antibodies

Hybridoma expressing anti-RG-1 mAb for the study of human papillomavirus L2

Technology DescriptionJHU scientists generated a hybridoma expressing a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising conserved residues neutralized pseudoviruses HPV5,...

Published: 7/23/2026 | Inventor(s): Ratish Gambhira, Richard Roden

Keywords(s): Antibodies, Basic Research Biomarker, Cell Model, Discovery/Research Tools, Hybridomas, In Vitro Research Tool, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Highly Specific Monoclonal Antibodies for Human ZnT8

Unmet NeedType 2 diabetes (T2D) is a growing worldwide public health issue affecting over 500 million people while creating a $1 trillion economic burden on global healthcare economies. Many current and new therapeutics demonstrate varying degrees of effectiveness, but no single agent or combination thereof has been able to provide patients with lasting...

Published: 7/24/2026 | Inventor(s): Dax Fu, Chengfeng Merriman

Keywords(s): Antibodies, Biologics, Diabetes, Discovery/Research Tools, Disease Indication, Metabolic Disorders, Monoclonal Antibodies, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker, Type II Diabetes

Category(s): Technology Classifications > Research Tools > Research Antibodies, Clinical and Disease Specializations > Diabetes > Type 2 Diabetes, Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies

Antibodies to Visual Pigment Proteins, Transcription Factor Sox17, and Multimerized Epitope Tags

Unmet Need:Canonical Wnt signaling is one of the major pathways involved in embryonic development and tissue regeneration. Recent studies suggest that canonical Wnt signaling is vital for brain angiogenesis and the acquisition of barrier properties by the microvasculature. There is a need in the field for the development of reagents that allow for the...

Published: 7/24/2026 | Inventor(s): Jeremy Nathans

Keywords(s): Antibodies, Discovery/Research Tools, Labels/Markers, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Research Antibodies

Single-chain Knobs-in-holes Bispecific Antibody Construction

Unmet Need: In the United States, 40% of males and 38% of females will develop cancer in their lifetimes. Additionally, as of 2015, the annual direct medical costs of cancer stood at $80.2 billion. Targeted therapies, such as monoclonal antibody drugs, show great promise in cancer treatment, but these therapies still have many important limitations...

Published: 7/24/2026 | Inventor(s): Jamie Spangler, Denis Wirtz, Huilin Yang, Wentao Wang, Michelle Karl

Keywords(s): Antibodies, Discovery/Research Tools, Monoclonal Antibodies, Research Reagent, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies, Technology Classifications > Research Tools > Research Antibodies

A Mouse Monoclonal Antibody Against Human LINE-1 ORF1p

Invention Novelty:Johns Hopkins researchers have developed a monoclonal antibody against the cancer-associated protein LINE-1 ORF1p. Technical Overview:There is great unmet need for a method of easily and broadly screening for cancer. Biomarkers, one of the major tools used in cancer screening, are usually specific for one cancer type, making testing...

Published: 7/23/2026 | Inventor(s): Kathleen Burns, Jef Boeke, Nemanja Rodic, Martin Taylor

Keywords(s): Antibodies, Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, Monoclonal Antibodies, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools

Monoclonal Antibodies Against the Barth Syndrome Gene Product, TAZ1, for Research and Diagnostic Applications

Unmet Need: Barth syndrome (BTHS) is an X-linked disease characterized by cardiac and skeletal myopathies, delayed growth until puberty, and cyclic neutropenia; if undiagnosed, affected boys have only a 30% chance of survival to age four. The BTHS gene TAFAZZIN encodes a monolysocardiolipn transacylase that is evolutionarily conserved from yeast to...

Published: 7/23/2026 | Inventor(s): Steven Claypool

Keywords(s): Antibodies, Barth Syndrome, Barth Syndrome (BTHS), Barth syndrome (BTHS), Discovery/Research Tools, Disease Indication, Genetic Disorders, Monoclonal Antibodies, Research Reagent, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Barth Syndrome, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Antibodies, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools

Monoclonal Antibodies Against Leukocyte Adhesion Receptor Beta-Chain, Methods of Producing These Antibodies and Use Therefore

Invention Novelty: This technology is a novel monoclonal antibody specific against an epitope that suppresses immune response mediated diseases such as AIDS.Value Proposition: Acquired immunodeficiency syndrome (AIDS) is a fatal, incurable disease characterized by profound immunosuppression, opportunistic infection and neuropathies. Current therapies...

Published: 7/23/2026 | Inventor(s): James Hildreth, Thomas August

Keywords(s): Antibodies, Discovery/Research Tools, Disease Indication, HIV/AIDS, Infectious Diseases, Monoclonal Antibodies, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS

An Adduct-specific Anti-thymidylate Synthase Antibody for Monitoring Fluorouracil Anticancer Therapy

TITLEAn Adduct-specific Anti-thymidylate Synthase Antibody for Monitoring Fluorouracil Anticancer TherapyCASE NUMBERC11954ABSTRACTWe developed a functional assay for a class of widely used anti-cancer drugs, 5-fluorouracil and related compounds (SFU). It is well established that SFU works largely by inhibiting the enzyme thymidylate synthase (TS) in...

Published: 7/23/2026 | Inventor(s): Kalpeshkumar Patel, Scott Kern

Keywords(s): Antibodies, Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, Monoclonal Antibodies, Pharmakodynamic Biomarker, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

CTD110.6 monoclonal antibody

Technical Details: O-linked N-acetylglucosamine (O-GlcNAc) is a newly described but ubiquitous dynamic modification of key regulatory proteins in side virtually all multi-cellular eukaryotic cells. Recently, this sugar modification has been shown to be as abundant as protein phosphorylation, often competing with this key regulatory switch in the cell?s...

Published: 7/23/2026 | Inventor(s): Frank Comer, Gerald Hart

Keywords(s): Alzheimer's Disease, Antibodies, Biologics, Cancers, CNS and Neurological Disorders, Diabetes, Discovery/Research Tools, Disease Indication, Metabolic Disorders, Monoclonal Antibodies, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Metabolic Diseases, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

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