Search Results - in+vivo+research+tool

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TC-1/A2

TITLE: TC-1/A2 cell lineCASE NUMBER: C04953TECHNOLOGYJHU Scientists characterized the ability of DNA-encoding calreticulin linked to DNA-encoding E7 antigen to generate HLA-A2-restricted E7-specific CD8+ T-cell responses in HLA-A2 (AAD) transgenic mice, as well as antitumor effects against an E7+ HLA-A2+ tumor cell line, TC-1/A2.TECHNICAL DETAILSScientists...

Published: 6/20/2024 | Inventor(s): Chien-Fu Hung, T.c. Wu

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

B7-DC Knockout Mice

Detailed DescriptionThe Pdcd1lg2 gene encodes the costimulatory molecule PD-L2 which is expressed in dendritic cells (DCs). To establish the mouse line Stk 017515 - B6N.129(Cg)-Pdcd1lg2tm2Dmp/J which is deficient for PD-L2, a genomic fragment containing exon 2 of the programmed cell death 1 ligand 2 (Pdcd1lg2 which encodes PD-L2) gene, two of loxP sites...

Published: 6/20/2024 | Inventor(s): Drew Pardoll, Lieping Chen, Kevin Gorski, Haruo Tsuchiya, Tahiro Shin

Keywords(s): Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models

Targeting PTPN22 in Cancer Therapy

Unmet NeedTumor-infiltrating lymphocytes (TILs) such as B-cells, T-cells, and natural killers are gaining traction in anti-tumor immune responses. TILs involve the use of special immune cells called T-cells, otherwise known as lymphocytes, which protect the body from viral infections, fight cancer, and coordinate the activities of other cells during...

Published: 6/20/2024 | Inventor(s): Elizabeth Jaffee, Won Jin Ho, Soren Charmsaz

Keywords(s): Cancers, Combination, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Target, Targeted Therapy/Immunotherapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Research Tools > Animal Models

An ex vivo Model for Rapid Evaluation of Choroidal Mast Cell Degranulation

Unmet NeedAlmost 11 million people in the United States have symptoms of age-related macular degeneration (AMD). AMD is a multifactorial disease distinguished by progressive degeneration in the macular region of the eye, resulting in irreversible central vision loss among the elderly population. Current evidence suggests that inflammation plays a vital...

Published: 6/20/2024 | Inventor(s): Gerard Lutty, Shuntaro Ogura

Keywords(s): Discovery/Research Tools, Disease Indication, Eye Disorders, In Vitro Research Tool, In Vivo Research Tool, Macular Degeneration, Rat Model, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Assays, Clinical and Disease Specializations > Ophthalmology > Macular Degeneration, Clinical and Disease Specializations > Ophthalmology > Dry Age-Related Macular Degeneration

Method for Labeling, Purifying, Enriching and Magnetic Resonance Imaging of Extracellular Vesicles Using Surface-functionalized Magnetic Particles

Unmet NeedExtracellular vesicles (EVs) are membrane structures that are naturally occurring and act as carriers for DNA, RNA, or nutrients. Recently EVs have also been looked at as potential drug delivery systems or carriers of biomarkers for particular diseases. MRI is a non-invasive method to image EVs and study their movement and distribution throughout...

Published: 6/20/2024 | Inventor(s): Guanshu Liu, Zheng Han

Keywords(s): Discovery/Research Tools, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, In Vivo Research Tool

Category(s): Technology Classifications > Diagnostics > Diagnostic Imaging

Tll1 Bmp1 Double Mutant – JHU Developed

Invention Novelty: The Johns Hopkins researchers have developed BTKO mice having floxed alleles for both Bmp1 and Tll1, such that they can be conditionally knocked out either temporally, postnatally, or in a tissue-specific, non-lethal manner and have overcome issues of functional redundancy. Value Proposition: Osteogenesis imperfecta (OI), or brittle...

Published: 6/20/2024 | Inventor(s): Se-Jin Lee

Keywords(s): Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Skeletal Disorders, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Sav1 Conditional Knockout Mice

Unmet NeedThe Hippo signaling pathway governs organ size, tissue homeostasis and regeneration, through its control of cellular proliferation, survival and apoptosis. Its dysregulation has been implicated in cancer, fibrosis, and cardiovascular disease. Research tools that improve our understanding of Hippo pathway function in healthy and disease states...

Published: 6/20/2024 | Inventor(s): Duojia Pan, Nailing Zhang

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models

Anastasis Biosensor CaspaseTracker rtTA

Anastasis Biosensor CaspaseTracker rtTA – C15014 Unmet NeedAnastasis, Greek for "rising to life", is a newly discovered cell recovery phenomenon by which a cell undergoes reversal of apoptosis or programmed cell death. Research has shown that even cells that exhibit the hallmarks of late-stage cell death such as activation of executioner caspases...

Published: 6/20/2024 | Inventor(s): Ho Lam Tang, Ho Man Holly Tang

Keywords(s): Animal Imaging Tools, apoptosis, Biomarker, Clinical Diagnostics, Discovery/Research Tools, Imaging Agent, Imaging and Sensing Systems, In Vitro Diagnostics, In Vivo Medical Imaging, In Vivo Research Tool, Labels/Markers, Research Reagent

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Biomarkers

C13783 - Pirt-Cre Mice

Invention novelty: JHU researchers have generated generated Pirt-Cre mice in which Cre recombinase is expressed specifically in all primary sensory neurons in dorsal root ganglion (DRG) under the control of Pirt promoter. Value Proposition:Primary sensory neurons in dorsal root ganglion (DRG) play essential role in initiating, transmitting, and modulating...

Published: 6/20/2024 | Inventor(s): Xinzhong Dong

Keywords(s): Basic Research Biomarker, Chronic Pain, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Itch, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Itch

Conditional Tau Mouse Lines that Faithfully Recapitulate Alzheimer’s Disease-like Pathologies

Value Proposition: Effective therapy for Alzheimer’s disease (AD), the most common form of dementia and a devastating illness for the elderly, remains a great unmet need. For translational research and preclinical drug development, animal models that faithfully mimic the cardinal pathological features of AD are critical. A major limitation of current...

Published: 6/20/2024 | Inventor(s): Philip Wong, Donald Price, Tong Li

Keywords(s): Alzheimer's Disease, Basic Research Biomarker, Cell Lines, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Mouse Cell Lines, Mouse Model, Neurodegeneration

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

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