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B7-DC Knockout Mice

Detailed DescriptionThe Pdcd1lg2 gene encodes the costimulatory molecule PD-L2 which is expressed in dendritic cells (DCs). To establish the mouse line Stk 017515 - B6N.129(Cg)-Pdcd1lg2tm2Dmp/J which is deficient for PD-L2, a genomic fragment containing exon 2 of the programmed cell death 1 ligand 2 (Pdcd1lg2 which encodes PD-L2) gene, two of loxP sites...

Published: 3/14/2025 | Inventor(s): Drew Pardoll, Lieping Chen, Kevin Gorski, Haruo Tsuchiya, Tahiro Shin

Keywords(s): Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models

Targeting PTPN22 in Cancer Therapy

Unmet NeedTumor-infiltrating lymphocytes (TILs) such as B-cells, T-cells, and natural killers are gaining traction in anti-tumor immune responses. TILs involve the use of special immune cells called T-cells, otherwise known as lymphocytes, which protect the body from viral infections, fight cancer, and coordinate the activities of other cells during...

Published: 3/14/2025 | Inventor(s): Elizabeth Jaffee, Won Jin Ho, Soren Charmsaz

Keywords(s): Cancers, Combination, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Target, Targeted Therapy/Immunotherapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Research Tools > Animal Models

Tll1 Bmp1 Double Mutant – JHU Developed

Invention Novelty: The Johns Hopkins researchers have developed BTKO mice having floxed alleles for both Bmp1 and Tll1, such that they can be conditionally knocked out either temporally, postnatally, or in a tissue-specific, non-lethal manner and have overcome issues of functional redundancy. Value Proposition: Osteogenesis imperfecta (OI), or brittle...

Published: 3/13/2025 | Inventor(s): Se-Jin Lee

Keywords(s): Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Skeletal Disorders, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Musculoskeletal, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Sav1 Conditional Knockout Mice

Unmet NeedThe Hippo signaling pathway governs organ size, tissue homeostasis and regeneration, through its control of cellular proliferation, survival and apoptosis. Its dysregulation has been implicated in cancer, fibrosis, and cardiovascular disease. Research tools that improve our understanding of Hippo pathway function in healthy and disease states...

Published: 3/14/2025 | Inventor(s): Duojia Pan, Nailing Zhang

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models

PKD2 Neo Mouse Line (also called Pkd2cond mutant)

Conditional Mouse Model of Polycystic Kidney Disease (PKD2Cond)JHU REF: C11721Material available at Jackson Laboratory (www.jax.org)Stock No: 017292 - B6.129X1(Cg)-Pkd2tm1.1Tjwt/JInvention novelty: This tangible material is a transgenic mouse strain with a mutant Pkd2 (Polycystic Kidney Disease 2) gene. This Pkd2 conditional mouse model may be used...

Published: 3/13/2025 | Inventor(s): Gregory Germino, Terry Watnick

Keywords(s): Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Genetically Engineered Mice

ABSTRACTJHU researchers have constructed a wide variety of genetically engineered mice that are useful for research. FEATURESThe collection includes gene knockout mice and a variety of fluorescent reporter mice. It allows an investigator to monitor the effect of gene knock out or the results of selective expression of reporters in defined cells/tissues....

Published: 3/13/2025 | Inventor(s): Jeremy Nathans

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

C09948: A Mouse Model of Hemophilia A

Overview: These knock-out mice are deficient of endogenous Factor VIII making them useful for hemophilia A studies. The mice are available via The Jackson Laboratory Strain: 004424; B6;129S4-F8tm1Kaz/JTechnical DetailsMice that are homozygous for the targeted, X chromosome-linked mutant allele are viable and fertile. Homozygous females and carrier males...

Published: 3/13/2025 | Inventor(s): Haig Kazazian, John Gearhart, Ann Lawler, Lilia Bi

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, Genetic Disorders, Hemophilia, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Hemophilia, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools

024414 B6129(SJL)-Grip1-tm1Rlh, 024415 B6.129S6(Cg)-Wwc1-tm1.1Rlh, 024417 B6.129S6(SJL)-Prkcz-tm1.1Rlh, 024418 B6.129S6-Gria1-tm7Rlh, 024419 B6.129(Cg)-Gria2-tm2Rlh, 024420 B6.129(Cg)-Gria1-tm4Rlh

TITLE: 024414 B6.129(SJL)-Grip1tm1Rlh 024415 B6.129S6(Cg)-Wwc1tm1.1Rlh024417 B6.129S6(SJL)-Prkcz tm1.1Rlh024418 B6.129S6-Gria1tm7Rlh 024419 B6.129(Cg)-Gria2tm2Rlh024420 B6.129(Cg)-Gria1tm4Rlh CASE NUMBER: C13635ABSTRACTInformation are from Jacksons Lab website (https://www.jax.org/mouse-search?searchTerm=Richard%20Huganir)Stock No. 024414 B6.129(SJL)-Grip1tm1Rlh...

Published: 3/13/2025 | Inventor(s): Richard Huganir

Keywords(s): CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Psychiatric Diseases, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

CCL20 Reporter and Conditional Knockout Mice

TITLE CCL20 Reporter and Conditional Knockout MiceCASE NUMBERC13357ABSTRACTCCL20 a member of the macrophage inflammatory protein family and signal through the receptor CCR6, genomic location have been identified as a region important for bone quality. However, the role of CCL20 signaling in regulating...

Published: 3/13/2025 | Inventor(s): Scott Kominsky

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Inflammatory Disorders, Knock Out Mouse Model, Mouse Model, Skeletal Disorders

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Inflammation

Ankyrin-G Conditional Forebrain Knockout Mouse Model of Human Psychiatric Disorders

TITLE Ankyrin-G Conditional Forebrain Knockout Mouse Model of Human Psychiatric DisordersCASE NUMBERC13170ABSTRACTThe Ankyrin-G locus has emerged from Genome-Wide Association Studies as one of the risk factors for human psychiatric disorders. It has been positive mainly in studies of bipolar disorder,...

Published: 3/13/2025 | Inventor(s): Christopher Ross, Shanshan Zhu, Vann Bennett

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

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