Search Results - mouse+model+xenograft

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Generation of Tetracycline-Regulatable Conditional AIMP2 (Aminoacyl-tRNA Synthetase Complex-interacting Multifunctional Protein 2) Transgenic Mice

Transgenic Mouse Model for Parkinson’s Disease JHU REF: [C12196] Invention novelty: This tangible material is a transgenic mice model expressing AIMP2 (Aminoacyl-tRNA synthetase complex-interacting multifunctional protein 2), a protein strongly associated with pathogenesis of Parkinson’s disease (PD). Value Proposition: No animal models overexpressing...

Published: 9/26/2024 | Inventor(s): Lino Tessarollo, Valina Dawson, Yunjong Lee, Debbie Swing, Ted Dawson

Keywords(s): CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Parkinson's Disease, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Genetically Engineered Mice

ABSTRACTJHU researchers have constructed a wide variety of genetically engineered mice that are useful for research. FEATURESThe collection includes gene knockout mice and a variety of fluorescent reporter mice. It allows an investigator to monitor the effect of gene knock out or the results of selective expression of reporters in defined cells/tissues....

Published: 9/26/2024 | Inventor(s): Jeremy Nathans

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

SCID hprt-null, NOG hprt-null mice

Mouse models to cultivate cancer cellsJHU REF: [C12012 and C05132]Invention novelty: Propagation of human cancer cells in immunodeficient mice and isolation of these cells without contamination with mouse cells.Value Proposition: • These mouse lines may be used for various applications including: Cancer cell line isolation. These mice may...

Published: 9/26/2024 | Inventor(s): James Eshleman, Anirban Maitra

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, In Vivo Research Tool, Mouse Cell Lines, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Wnt Signaling Mice

Title: Wnt Signaling Mice JHU ref: C10729 JAX Stock No: 008614 B6;129-Sfrp2tm1Nat/J DESCRIPTION LacZ and a selectable neomycin marker replace the first coding exon of the frizzled-related protein 2 gene in this targeted mutation strain. Homozygotes exhibit mild syndactyly of the toes of the hind legs and are viable and fertile....

Published: 9/26/2024 | Inventor(s): Jeremy Nathans

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

IDH1 Mutant Glioma Xenograft (JHH-273)

Invention Novelty: A stable, patient-derived IDH- 1 mutant glioma xenograft designed to evaluate potential IDH targeted drug therapies.Value Proposition: IDH-1 (Isocitrate Dehydrogenase) is a very common mutation observed in low-grade glioma tumors. Current IDH-mutated cell lines lack sufficient genetic characteristics similar to human pathologies and...

Published: 9/26/2024 | Inventor(s): Alexandra Borodovsky, Gregory Riggins

Keywords(s): Basic Research Biomarker, Brain Cancer, Cancers, Discovery/Research Tools, Disease Indication, Glioma, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology > Glioma, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

Chemically-induced Mutations of Sema3a, Sec24b, and Megf8 in Mouse

MUTATIONS OF SEMA3A, SEC24B, AND MEGF8 IN MOUSE MODELSJHU REF: C12484 Invention novelty: This tangible material includes a mutant strain of mice produced by inducing chemical mutations of SEMA3A, SEC24B and MEGf8 mutations in mouse models. Value PropositionSema3a point mutant miceSec24b point mutant mice Megf8L1775P point mutant mouseTechnical DetailsJohns...

Published: 9/26/2024 | Inventor(s): Janna Merte, David Ginty

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Chemically-induced Mutations of B3gnt1 and Ispd in Mouse

MUTANT MOUSE MODELS FOR NEURODEVELOPMENTAL RESEARCH JHU REF: C12482Invention novelty: This tangible material includes mouse models with mutant B3gnt1 and Ispd genes.Value PropositionMouse strains with chemically-induced mutations of B3gnt1 and Ispd genes.Technical DetailsJohns Hopkins researchers have developed chemically altered mouse strain with mutations...

Published: 9/26/2024 | Inventor(s): Kevin Wright, David Ginty

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

CPT1c Conditional Transgenic Mice

CPTlc conditional transgenic miceJHU REF: C10555Brief Description:Carnitine Palmitoyltransferase 1C (CPT1c) conditional transgenic Mice are useful for determining the enaymatic and physiologic function of CPTlc enzymesand for developing inhibitors of CPT1c.

Published: 9/26/2024 | Inventor(s): Michael Wolfgang

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

A Novel Obesity Model: Human Synphilin-1 Transgenic Mouse

Invention novelty: The technology is a transgenic mouse strain (SP1) utilizing synphilin-1 to control food intake and body weight thus providing a convenient model for obesity studies.Value Proposition: The technology provides a unique genetic obesity model for future studies of the pathogenesis of obesity and related disorders.Key features include:-...

Published: 9/26/2024 | Inventor(s): Christopher Ross, Timothy Moran, Wanli Smith

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Metabolic Disorders, Mouse Model, Mouse Model Xenograft, Obesity

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Metabolic Diseases > Obesity, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Research Tools

Histone Reporter Alleles: Tools for in vitro and in vivo Epigenetic Therapeutic Development - Treatment Method

METHODS FOR TREATING MENDELIAN DISORDERS OF THE EPIGENETICMACHINERYJHU REF: C13083Invention novelty: A genetically encoded histone reporter allele system which can be utilized for high throughput screening in in vitro cellular systems.Value Proposition: Epigenetic modifications are thought to be one of the critical mechanisms that mediate gene-environment...

Published: 9/26/2024 | Inventor(s): Harry Dietz, Hans Bjornsson

Keywords(s): Basic Research Biomarker, Biomarker, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, Epigenetic, Genetic Disorders, In Vitro Diagnostics (Old), In Vitro Research Tool, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Assays, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Diagnostics > Biomarkers

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