Search Results - mouse+model+xenograft

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Generation of Tetracycline-Regulatable Conditional AIMP2 (Aminoacyl-tRNA Synthetase Complex-interacting Multifunctional Protein 2) Transgenic Mice

Transgenic Mouse Model for Parkinson’s Disease JHU REF: [C12196] Invention novelty: This tangible material is a transgenic mice model expressing AIMP2 (Aminoacyl-tRNA synthetase complex-interacting multifunctional protein 2), a protein strongly associated with pathogenesis of Parkinson’s disease (PD). Value Proposition: No animal models overexpressing...

Published: 10/23/2025 | Inventor(s): Lino Tessarollo, Valina Dawson, Yunjong Lee, Debbie Swing, Ted Dawson

Keywords(s): CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Parkinson's Disease, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Genetically Engineered Mice

ABSTRACTJHU researchers have constructed a wide variety of genetically engineered mice that are useful for research. FEATURESThe collection includes gene knockout mice and a variety of fluorescent reporter mice. It allows an investigator to monitor the effect of gene knock out or the results of selective expression of reporters in defined cells/tissues....

Published: 10/23/2025 | Inventor(s): Jeremy Nathans

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

SCID hprt-null, NOG hprt-null mice

Mouse models to cultivate cancer cellsJHU REF: [C12012 and C05132]Invention novelty: Propagation of human cancer cells in immunodeficient mice and isolation of these cells without contamination with mouse cells.Value Proposition: • These mouse lines may be used for various applications including: Cancer cell line isolation. These mice may...

Published: 10/23/2025 | Inventor(s): James Eshleman, Anirban Maitra

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, In Vivo Research Tool, Mouse Cell Lines, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Wnt Signaling Mice

Title: Wnt Signaling Mice JHU ref: C10729 JAX Stock No: 008614 B6;129-Sfrp2tm1Nat/J DESCRIPTION LacZ and a selectable neomycin marker replace the first coding exon of the frizzled-related protein 2 gene in this targeted mutation strain. Homozygotes exhibit mild syndactyly of the toes of the hind legs and are viable and fertile....

Published: 10/23/2025 | Inventor(s): Jeremy Nathans

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

IDH1 Mutant Glioma Xenograft (JHH-273)

Invention Novelty: A stable, patient-derived IDH- 1 mutant glioma xenograft designed to evaluate potential IDH targeted drug therapies.Value Proposition: IDH-1 (Isocitrate Dehydrogenase) is a very common mutation observed in low-grade glioma tumors. Current IDH-mutated cell lines lack sufficient genetic characteristics similar to human pathologies and...

Published: 10/23/2025 | Inventor(s): Alexandra Borodovsky, Gregory Riggins

Keywords(s): Basic Research Biomarker, Brain Cancer, Cancers, Discovery/Research Tools, Disease Indication, Glioma, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology > Glioma, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

Chemically-induced Mutations of Sema3a, Sec24b, and Megf8 in Mouse

Value Proposition· Novel loss-of-function mutations: Three distinct ENU-induced point mutations (Sema3A^K108N, Sec24b^Y613X, and Megf8^L1775P) that create specific loss-of-function phenotypes while maintaining protein expression and secretion· Validated genetic models: Each strain has been thoroughly characterized and phenotypically validated...

Published: 10/23/2025 | Inventor(s): Janna Merte, David Ginty

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Chemically-induced Mutations of B3gnt1 and Ispd in Mouse

Value Proposition· Human disease relevance: Recapitulate key dystroglycanopathy features including cobblestone lissencephaly, neuronal migration defects, and muscular dystrophy· Complementary severity spectrum: B3gnt1 mutants survive to adulthood with mild symptoms; Crppa mutants show severe early phenotypes· Drug discovery ready: Enable...

Published: 10/23/2025 | Inventor(s): Kevin Wright, David Ginty

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

CPT1c Conditional Transgenic Mice

CPTlc conditional transgenic miceJHU REF: C10555Brief Description:Carnitine Palmitoyltransferase 1C (CPT1c) conditional transgenic Mice are useful for determining the enaymatic and physiologic function of CPTlc enzymesand for developing inhibitors of CPT1c.

Published: 10/23/2025 | Inventor(s): Michael Wolfgang

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

A Novel Obesity Model: Human Synphilin-1 Transgenic Mouse

Invention novelty: The technology is a transgenic mouse strain (SP1) utilizing synphilin-1 to control food intake and body weight thus providing a convenient model for obesity studies.Value Proposition: The technology provides a unique genetic obesity model for future studies of the pathogenesis of obesity and related disorders.Key features include:-...

Published: 10/23/2025 | Inventor(s): Christopher Ross, Timothy Moran, Wanli Smith

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Metabolic Disorders, Mouse Model, Mouse Model Xenograft, Obesity

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Metabolic Diseases > Obesity, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Research Tools

Histone Reporter Alleles: Tools for in vitro and in vivo Epigenetic Therapeutic Development - Treatment Method

METHODS FOR TREATING MENDELIAN DISORDERS OF THE EPIGENETICMACHINERYJHU REF: C13083Invention novelty: A genetically encoded histone reporter allele system which can be utilized for high throughput screening in in vitro cellular systems.Value Proposition: Epigenetic modifications are thought to be one of the critical mechanisms that mediate gene-environment...

Published: 10/23/2025 | Inventor(s): Harry Dietz, Hans Bjornsson

Keywords(s): Basic Research Biomarker, Biomarker, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, Epigenetic, Genetic Disorders, In Vitro Diagnostics (Old), In Vitro Research Tool, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Assays, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Diagnostics > Biomarkers

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