Search Results - lino+tessarollo

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Generation of Tetracycline-Regulatable Conditional AIMP2 (Aminoacyl-tRNA Synthetase Complex-interacting Multifunctional Protein 2) Transgenic Mice

Invention novelty: This tangible material is a transgenic mice model expressing AIMP2 (Aminoacyl-tRNA synthetase complex-interacting multifunctional protein 2), a protein strongly associated with pathogenesis of Parkinson’s disease (PD). Value Proposition: No animal models overexpressing human AIMP2 exist. These transgenic mice are tools that can facilitate...

Published: 6/12/2026 | Inventor(s): Lino Tessarollo, Valina Dawson, Yunjong Lee, Debbie Swing, Ted Dawson

Keywords(s): CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Parkinson's Disease, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

CUG Expressing tg Mice

Value Proposition: These transgenic mouse models express a short untranslatable fragment of exon 2A of the gene junctophilin 3 (JPH3) containing either 10 or 100 consecutive CUG triplets in the brain. Relevant publication: Rudnicki et al. Huntington's disease-like 2 is associated with CUG repeat-containing RNA foci. Ann Neurol. 2007 Mar;61(3):272-82. Technical...

Published: 6/12/2026 | Inventor(s): Lino Tessarollo, Russell Margolis, Christopher Ross, Dobrila Rudnicki

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools