Search Results - basic+research+biomarker

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Incorporation of Lysine Tags as a Universal System for Controlling Protein Expression

Value Proposition· Precise and Tunable Protein Translation Control: Poly(A) track length can be varied from 1-12 AAA codons, providing precise and adjustable control over protein output.· Minimal Complexity: This technology offers predictable, graded control of protein expression using only a short DNA sequence insert—no external inducers,...

Published: 1/22/2026 | Inventor(s): Dorothy Green, Sergej Djuranovic

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Nucleotide, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools

NK1-Cre mice

Invention novelty: Project neurons in the spinal cord play essential role in transmitting and modulating pain and itch signals from the periphery. NK1 is the receptor of the major pain and itch neurotransmitter peptide substance P. NK1 is expressed in the project neurons in the dorsal horn of the spinal cord. Dysfunction of these neurons often leads...

Published: 1/22/2026 | Inventor(s): Xinzhong Dong

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

SCA12 Tools – SCA12 Fibroblasts, iPSCs and Polyclonal Antibodies to Investigate SCA12

Value PropositionFirst in class patient-derived biological tools for investigation of SCA12, a rare neurodegenerative disease with no known cure. Unmet NeedSpinocerebellar ataxia type 12 (SCA12) is a rare neurodegenerative disease that affects the cerebellum, commonly resulting in upper limb tremors and muscle spasms, with some patients reporting a...

Published: 1/22/2026 | Inventor(s): Russell Margolis, Pan Li, Christopher Ross

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Neurology > Neurodegeneration

TH-2A-CreER Mice

Value Proposition· Enhanced labeling efficiency: The TH-2A-CreER mouse line achieves higher labeling efficiency compared to existing mouse lines through the 2A peptide system that ensures elevated CreER expression levels· Multi-population targeting: Enables labeling and functional manipulation of TH-expressing neuronal populations including...

Published: 1/22/2026 | Inventor(s): David Ginty

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Efficient, Expansive, User-defined DNA Mutagenesis

C12015: Efficient, Expansive, User-defined DNA MutagenesisNovelty: This invention provides a leap forward in saturation mutagenesis called PFunkel. PFunkel is a next-generation Kunkel mutagenesis strategy that can, for the first time, efficiently and cheaply produce libraries containing user-defined mutations, including sequentially permuted genes....

Published: 1/22/2026 | Inventor(s): Elad Firnberg, Marc Ostermeier

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Know-how

Category(s): Technology Classifications > Research Tools

K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells

C10037: K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells Technical Details: Single oncogenic point mutation in codon 12 of K-Ras was "knocked in" to the commercially available MCF-l0A cell line and two other hTERT immortalized human breast epithelial cell lines. Looking for Partners: The cell lines described in this...

Published: 1/22/2026 | Inventor(s): Ben Ho Park

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, Discovery/Research Tools, Epithelial Cells, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

Hybridoma expressing anti-RG-1 mAb for the study of human papillomavirus L2

Technology DescriptionJHU scientists generated a hybridoma expressing a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising conserved residues neutralized pseudoviruses HPV5,...

Published: 1/22/2026 | Inventor(s): Ratish Gambhira, Richard Roden

Keywords(s): Antibodies, Basic Research Biomarker, Cell Model, Discovery/Research Tools, Hybridomas, In Vitro Research Tool, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Diazen-1-ium-1, 2-diolate Derivatives as New Nitroxyl Donors

Unmet NeedHeart failure is a continuously growing health issue in the United States. According to a study by the CDC, approximately 6.2 million Americans had heart failure between the years 2013-2016, and that number is expected to breach 8 million by 2030 (see AHA). Acute decompensated heart failure (ADHF), a potentially fatal cause of respiratory...

Published: 1/22/2026 | Inventor(s): Christopher Pavlos, Preeya Kapur Boppana, John Toscano

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Alpha 2 Collagen VIII (Col8a2) Q455K Knock-in Mouse Model of Fuchs Endothelial Corneal Dystrophy

Unmet Need:Fuchs’ endothelial corneal dystrophy (FECD) is a genetic disease affecting the cornea and is estimated to affect 7% of the adult population (see Aiello et al. 2022). The first genetic defect shown to cause FECD was a point mutation in the alpha 2 collagen 8 gene (Col8a2). The disease results in a buildup of fluid in the cornea and causes...

Published: 1/22/2026 | Inventor(s): Albert Jun

Keywords(s): Basic Research Biomarker, Cell Lines, Corneal Dystrophy, Discovery/Research Tools, Disease Indication, Eye Disorders, Fuchs' Endothelial Corneal Dystrophy, Fuchs Endothelial Corneal Dystrophy (FECD), In Vitro Research Tool, Mouse Cell Lines

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy, Clinical and Disease Specializations > Ophthalmology > Fuchs' Endothelial Corneal Dystrophy

Antigens for preparation of monoclonal antibodies

Unmet NeedMonoclonal Antibodies (mAB) serve an important role in both research and medical applications to better understand components of biochemical pathways and the development of chronic diseases (Tabrizi et al, 2006[SN1] ). There is a global need for the advancement of antibodies to help target and fully understand the various, complex, molecular,...

Published: 1/22/2026 | Inventor(s): Gerald Hart

Keywords(s): Antigens, Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

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