🔍
Search Results - basic+research+biomarker
280
Results
Sort By:
Published Date
Updated Date
Title
ID
Descending
Ascending
Efficient, Expansive, User-defined DNA Mutagenesis
C12015: Efficient, Expansive, User-defined DNA MutagenesisNovelty: This invention provides a leap forward in saturation mutagenesis called PFunkel. PFunkel is a next-generation Kunkel mutagenesis strategy that can, for the first time, efficiently and cheaply produce libraries containing user-defined mutations, including sequentially permuted genes....
Published: 3/13/2025
|
Inventor(s):
Elad Firnberg
,
Marc Ostermeier
Keywords(s):
Basic Research Biomarker
,
Discovery/Research Tools
,
In Vitro Research Tool
,
Know-how
Category(s):
Technology Classifications > Research Tools
K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells
C10037: K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells Technical Details: Single oncogenic point mutation in codon 12 of K-Ras was "knocked in" to the commercially available MCF-l0A cell line and two other hTERT immortalized human breast epithelial cell lines. Looking for Partners: The cell lines described in this...
Published: 3/13/2025
|
Inventor(s):
Ben Ho Park
Keywords(s):
Basic Research Biomarker
,
Cell Lines
,
Cell Model
,
Discovery/Research Tools
,
Epithelial Cells
,
Human Cell Lines
,
In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools > Human Cell Lines
,
Technology Classifications > Research Tools
Hybridoma expressing anti-RG-1 mAb for the study of human papillomavirus L2
Technology DescriptionJHU scientists generated a hybridoma expressing a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising conserved residues neutralized pseudoviruses HPV5,...
Published: 3/13/2025
|
Inventor(s):
Ratish Gambhira
,
Richard Roden
Keywords(s):
Antibodies
,
Basic Research Biomarker
,
Cell Model
,
Discovery/Research Tools
,
Hybridomas
,
In Vitro Research Tool
,
Monoclonal Antibodies
,
Research Reagent
Category(s):
Technology Classifications > Research Tools > Antibodies
,
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools
Diazen-1-ium-1, 2-diolate Derivatives as New Nitroxyl Donors
Unmet NeedHeart failure is a continuously growing health issue in the United States. According to a study by the CDC, approximately 6.2 million Americans had heart failure between the years 2013-2016, and that number is expected to breach 8 million by 2030 (see AHA). Acute decompensated heart failure (ADHF), a potentially fatal cause of respiratory...
Published: 3/13/2025
|
Inventor(s):
Christopher Pavlos
,
Preeya Kapur Boppana
,
John Toscano
Keywords(s):
Basic Research Biomarker
,
Discovery/Research Tools
,
Enzymes
,
Recombinant Proteins
,
Research Reagent
Category(s):
Technology Classifications > Research Tools > Proteins, Ligands & Receptors
,
Technology Classifications > Research Tools
Alpha 2 Collagen VIII (Col8a2) Q455K Knock-in Mouse Model of Fuchs Endothelial Corneal Dystrophy
Unmet Need:Fuchs’ endothelial corneal dystrophy (FECD) is a genetic disease affecting the cornea and is estimated to affect 7% of the adult population (see Aiello et al. 2022). The first genetic defect shown to cause FECD was a point mutation in the alpha 2 collagen 8 gene (Col8a2). The disease results in a buildup of fluid in the cornea and causes...
Published: 3/13/2025
|
Inventor(s):
Albert Jun
Keywords(s):
Basic Research Biomarker
,
Cell Lines
,
Corneal Dystrophy
,
Discovery/Research Tools
,
Disease Indication
,
Eye Disorders
,
Fuchs' Endothelial Corneal Dystrophy
,
Fuchs Endothelial Corneal Dystrophy (FECD)
,
In Vitro Research Tool
,
Mouse Cell Lines
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Rare Diseases
,
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools > Cell Lines
,
Clinical and Disease Specializations > Ophthalmology
,
Technology Classifications > Research Tools
,
Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy
,
Clinical and Disease Specializations > Ophthalmology > Fuchs' Endothelial Corneal Dystrophy
Antigens for preparation of monoclonal antibodies
Unmet NeedMonoclonal Antibodies (mAB) serve an important role in both research and medical applications to better understand components of biochemical pathways and the development of chronic diseases (Tabrizi et al, 2006[SN1] ). There is a global need for the advancement of antibodies to help target and fully understand the various, complex, molecular,...
Published: 3/13/2025
|
Inventor(s):
Gerald Hart
Keywords(s):
Antigens
,
Basic Research Biomarker
,
Cell Signaling
,
Discovery/Research Tools
,
Research Reagent
Category(s):
Technology Classifications > Research Tools > Proteins, Ligands & Receptors
,
Technology Classifications > Research Tools
Mouse Monoclonal Antibody 8A2
Unmet NeedMonoclonal Antibodies (mAB) serve an important role in cellular research and therapeutic applications. They are utilized to better understand various systems such as biochemical pathways, diseases, and mutations in the structures of invertebrates. There is a need to develop antibodies that specifically target areas within the biological landscape...
Published: 3/13/2025
|
Inventor(s):
Michael Matunis
Keywords(s):
Basic Research Biomarker
,
Discovery/Research Tools
,
Proteomics/Immunoassays
,
Proteomics/Immunoassays Antibodies
,
Research Reagent
Category(s):
Technology Classifications > Research Tools > Antibodies
,
Technology Classifications > Research Tools > Assays
,
Technology Classifications > Research Tools
TC-1/A2
TITLE: TC-1/A2 cell lineCASE NUMBER: C04953TECHNOLOGYJHU Scientists characterized the ability of DNA-encoding calreticulin linked to DNA-encoding E7 antigen to generate HLA-A2-restricted E7-specific CD8+ T-cell responses in HLA-A2 (AAD) transgenic mice, as well as antitumor effects against an E7+ HLA-A2+ tumor cell line, TC-1/A2.TECHNICAL DETAILSScientists...
Published: 3/13/2025
|
Inventor(s):
T.c. Wu
,
Chien-Fu Hung
Keywords(s):
Basic Research Biomarker
,
Discovery/Research Tools
,
In Vivo Research Tool
,
Knock In Mouse Model
,
Mouse Model
Category(s):
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools
Improved Production of Clavulanic Acid by Genetic Engineering of Streptomyces Clavuligerus
Clavulanic acid is a potent b-lactamase inhibitor used to combat resistance to penicillin and cephalosporin antibiotics. There is a demand for high-yielding fermentation strains for industrial production of this valuable product. Clavulanic acid biosynthesis is initiated by the condensation of L-arginine and D-glyceraldehyde-3-phosphate (G3P). To overcome...
Published: 3/13/2025
|
Inventor(s):
Rong-feng Li
,
Craig Townsend
Keywords(s):
Bacterial Infections
,
Basic Research Biomarker
,
Cell Signaling
,
Discovery/Research Tools
,
Disease Indication
,
Infectious Diseases
,
Inhibitors
,
Research Reagent
,
Therapeutic Method
,
Therapeutics
Category(s):
Clinical and Disease Specializations
,
Technology Classifications > Research Tools > Proteins, Ligands & Receptors
,
Technology Classifications > Therapeutic Modalities
,
Clinical and Disease Specializations > Infectious Diseases
,
Technology Classifications > Research Tools
,
Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections
Profiling of Interferon signaling to diagnose autoimmune disorders
Unmet Need / Invention Novelty: Diagnosing an autoimmune disease using standard laboratory tests is challenging and often requires secondary validation due to high rates of false positives and overlapping biological signatures with other diseases. There is a critical need for an improved method to detect autoimmune disease signatures in tissue collected...
Published: 3/13/2025
|
Inventor(s):
Livia Casciola-Rosen
,
Antony Rosen
,
John Hall
Keywords(s):
Autoimmune Diseases
,
Basic Research Biomarker
,
Biomarker
,
Clinical Diagnostics
,
Discovery/Research Tools
,
Disease Indication
,
In Vitro Diagnostics
,
In Vitro Research Tool
,
Inflammatory Disorders
,
Research Instrument
Category(s):
Technology Classifications > Research Tools
,
Technology Classifications > Diagnostics > Biomarkers
,
Clinical and Disease Specializations > Autoimmunity
1
2
3
4
5
6
7
8
9
10
...
JHTV Home
|
Search
|
Login/Subscribe
2017 - 2022 © Johns Hopkins Technology Ventures. All Rights Reserved. Powered by
Inteum