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Isogenic SF3B1 cell lines for drug discovery
SF3B1 mutations are present in a number of cancers. These mutations cause abnormal splicing within human cells and can lead to genomic alterations that confer cancerous phenotypes. Our research has led to the creation of isogenic cell lines that have specific mutations within the SF3B1 gene, thus mimicking human cancer mutations. In addition, we have...
Published: 9/26/2024
|
Inventor(s):
Ben Ho Park
,
William Dalton
Keywords(s):
Cell Lines
,
Discovery/Research Tools
,
Human Cell Lines
,
In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools > Human Cell Lines
ESR1 Mutations in Human Breast Cancer Cells
TITLE ESR1 mutations in human breast cancer cells CASE NUMBER C13950 ABSTRACT Newly discovered mutations in the estrogen receptor alpha gene, ESR1, are thought to predict for resistance to certain endocrine therapies in breast cancers that express hormone receptors. FEATURES Johns...
Published: 9/26/2024
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Inventor(s):
David Chu
,
Ben Ho Park
Keywords(s):
Cell Lines
,
Discovery/Research Tools
,
Human Cell Lines
,
In Vitro Research Tool
,
Target-based Screening Tool
,
Translational Research Biomarker
Category(s):
Technology Classifications > Research Tools
,
Technology Classifications > Research Tools > Human Cell Lines
Exon 20 Wildtype Control Knock in MCF-10A Cells
TITLE Exon 20 Wildtype Control Knock in MCF-10A Cells DESCRIPTION A human breast epithelial cell line (MCF-10A) with gene targeting resulting in no change in the PIK3CA gene after homologous recombination, (wildtype control). TANGIBLE MATERIAL: Human PIK3CA (H1047R/+) MCF10A Cell Line ASSOCIATED INSTITUTION Oncology, School of Medicine PI:...
Published: 9/26/2024
|
Inventor(s):
Ben Ho Park
Keywords(s):
Basic Research Biomarker
,
Cell Lines
,
Cell Model
,
Discovery/Research Tools
,
Epithelial Cells
,
Human Cell Lines
,
In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools > Human Cell Lines
,
Technology Classifications > Research Tools
Functional Analysis of Non-amplified/overexpressed HER2 L869R Heterozygous in Human Somatic Breast Cells
TITLE Functional analysis of non-amplified/overexpressed HER2 L869R heterozygous in human somatic breast cellsJHU Ref. #C13782ABSTRACTHuman epidermal growth factor receptor 2 (HER2) missense mutations have been reported in human cancers and primarily occur in the absence of HER2 gene amplification. Whether...
Published: 9/26/2024
|
Inventor(s):
Ben Ho Park
,
Daniel Zabransky
,
Sarah Croessmann
Keywords(s):
Breast Cancer
,
Cancers
,
Cell Lines
,
Discovery/Research Tools
,
Disease Indication
,
Human Cell Lines
,
In Vitro Research Tool
,
Translational Research Biomarker
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Oncology > Breast Cancer
,
Clinical and Disease Specializations > Women's Health
,
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools > Human Cell Lines
,
Clinical and Disease Specializations > Oncology
,
Technology Classifications > Research Tools
Overexpression of ntrk1 cDNA in the Nontumorgenic Breast Epithelial Cell Line MCF-10A
TITLE Overexpression of ntrk1 cDNA in the non tumorgenic breast epithelial cell line MCF-10AJHU Ref. #C13626ABSTRACTThe overexpression of ntrk1 cDNA in the pIRESneo3 plasmid in human non-cancerous breast epithelial cell line MCF-10A. Ntrk1 is amplified in some breast cancers and MCF-10A is a non-cancerous...
Published: 9/26/2024
|
Inventor(s):
Ben Ho Park
,
Kelly Kyker-Snowman
Keywords(s):
Breast Cancer
,
Cancers
,
Cell Lines
,
Discovery/Research Tools
,
Disease Indication
,
Human Cell Lines
,
In Vitro Research Tool
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Oncology > Breast Cancer
,
Clinical and Disease Specializations > Women's Health
,
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools > Human Cell Lines
,
Clinical and Disease Specializations > Oncology
,
Technology Classifications > Research Tools
PIK3CA wild type and AKT1 E17K and PIK3CA H1047R knock-in MCF-7 cells
C12186: PIK3CA Wild Type and AKT1 E17K and PIK3CA H1047R Knock-in MCF-7 CellsNovelty: MCF-7 derivatives with different mutations in the phosphatidylinositol-3-kinase (PI3-kinase) pathway gene PIK3CA and AKT1.Value Proposition: MCF-7 is the most widely used human breast cancer cell line, and it serves as a valuable model for preclinical investigations...
Published: 9/26/2024
|
Inventor(s):
Ben Ho Park
,
Josh Lauring
Keywords(s):
Breast Cancer
,
Cancer Cells
,
Cancers
,
Cell Lines
,
Cell Model
,
Discovery/Research Tools
,
Disease Indication
,
Human Cell Lines
,
In Vitro Research Tool
,
Translational Research Biomarker
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Oncology > Breast Cancer
,
Clinical and Disease Specializations > Women's Health
,
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools > Human Cell Lines
,
Clinical and Disease Specializations > Oncology
,
Technology Classifications > Research Tools
AKT1 Knock in Cells
C10605: AKT1 Knock in Cells Value Proposition: JHU scientists have generated a cell line incorporating a single base pair mutation “knocked in” within the AKT1 oncogene, single allele, into the MCF-10A human breast epithelial cell line resulting in a heterozygous E17K amino acid change. Additionally, a control “knock in” wild type cell line was...
Published: 9/26/2024
|
Inventor(s):
Josh Lauring
,
Ben Ho Park
Keywords(s):
Cell Lines
,
Cell Model
,
Discovery/Research Tools
,
Epithelial Cells
,
Human Cell Lines
,
In Vitro Research Tool
,
Translational Research Biomarker
Category(s):
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools > Human Cell Lines
,
Technology Classifications > Research Tools
MMSET Knock Out and Knock Down Multiple Myeloma Cells
C10575: MMSET Knock Out and Knock Down Multiple Myeloma Cells Value Proposition: • Effective knockout/knockdown Multiple Myeloma cells line for the study of t(4;14)(p16;q32), worst prognostic subgroup in Multiple Myeloma Patients. Technical Details: Multiple myeloma (MM) is an incurable hematologic malignancy characterized by recurrent chromosomal...
Published: 9/26/2024
|
Inventor(s):
Josh Lauring
,
Ben Ho Park
Keywords(s):
Basic Research Biomarker
,
Blood Cancer
,
Cancer Cells
,
Cancers
,
Cell Model
,
Discovery/Research Tools
,
Disease Indication
,
Hematologic Malignancies
,
In Vitro Research Tool
,
Multiple Myeloma
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Hematology
,
Clinical and Disease Specializations > Oncology > Hematologic Malignancies
,
Clinical and Disease Specializations > Oncology > Multiple Myeloma
,
Clinical and Disease Specializations > Rare Diseases
,
Technology Classifications > Research Tools > Cell Lines
,
Clinical and Disease Specializations > Oncology
,
Technology Classifications > Research Tools
,
Technology Classifications > Research Tools > Human Cell Lines
K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells
C10037: K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells Technical Details: Single oncogenic point mutation in codon 12 of K-Ras was "knocked in" to the commercially available MCF-l0A cell line and two other hTERT immortalized human breast epithelial cell lines. Looking for Partners: The cell lines described in this...
Published: 9/26/2024
|
Inventor(s):
Ben Ho Park
Keywords(s):
Basic Research Biomarker
,
Cell Lines
,
Cell Model
,
Discovery/Research Tools
,
Epithelial Cells
,
Human Cell Lines
,
In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools > Human Cell Lines
,
Technology Classifications > Research Tools
Estrogen Receptor in Knock out (ERIK) Cells
C10036: Estrogen Receptor in Knock out (ERIK) Cells Technical Details: Receptor positive non-tumorigenic human breast epithelial cell line derived from the commercially available MCF-10A human breast epithelial cell line with the p21 gene somatically deleted. Looking for Partners: The cell lines described in this invention can be used in screens...
Published: 9/26/2024
|
Inventor(s):
Ben Ho Park
Keywords(s):
Basic Research Biomarker
,
Cell Lines
,
Cell Model
,
Discovery/Research Tools
,
Epithelial Cells
,
Human Cell Lines
,
In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools > Human Cell Lines
,
Technology Classifications > Research Tools
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