Search Results - cancer+cells

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Artificial Lymph Nodes for T cell Immunotherapy

Unmet Need Adoptive T cell transfer immunotherapy is a promising approach for treating a variety of cancer tumors. They involve the removal, culture, and expansion of resident T cells ex-vivo several thousand fold before reinfusion back into the body. However, a concern with current culturing methods is their inconsistency in developing and retaining...

Published: 9/26/2024 | Inventor(s): Jonathan Schneck, John Hickey, Hai-Quan Mao

Keywords(s): Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, Immunotherapy, In Vitro Research Tool, Single, Therapeutic Matter, Therapeutic Method, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations > Immuno-Oncology

Semaphorin 3D and Plexin D1 as New Therapeutic Targets for Pancreatic Cancer Treatment

Unmet Need: Most patients with pancreatic ductal adenocarcinoma (PDA) present with metastatic disease at the time of diagnosis or will recur with metastases after surgical treatment. Technology Overview: Semaphorin-plexin signaling mediates the migration of neuronal axons during development and of blood vessels during angiogenesis. The expression of...

Published: 9/26/2024 | Inventor(s): Lei Zheng

Keywords(s): Biomarker, Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Mechanism-of-action Biomarker, Pancreatic Cancer, Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

Development of an in vitro Model of Metastatic Cancer

Unmet Need: Metastasis is by far the main cause of cancer lethality; the majority of cancer death from solid tumors are due to metastatic cancer spread from the tumor to other sites in the body. Key features of metastatic cascade are invasion, migration, and epithelial-mesenchymal transition (EMT). There are models of cancer cell metastasis but they...

Published: 9/26/2024 | Inventor(s): Shanmugasundaram Ganapathy-Kanniappan, Rani Kunjithapatham

Keywords(s): Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Unique Organ-specific Metastatic Human Breast Cancer Cell Lines

TITLEUnique organ-specific metastatic human breast cancer cell lines CASE NUMBERC13010 ABSTRACTA history of clinical observations has demonstrated that breast cancer metastases are capable of sustained deadly growth in several vital organs, such as, lung, brain, and liver as well as bone/marrow, ovaries, adrenals, lymph nodes, and skin. In order to...

Published: 9/26/2024 | Inventor(s): Venu Raman, Paul Winnard

Keywords(s): Breast Cancer, Cancer Cells, Cancers, Cell Lines, Cell Model, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

USP9x-deficient HCT116 and DLD-1 Cells

USP9X-deficient cancer cell linesJHU REF: [C11655]Invention novelty: The technology consists of colorectal cancer cell lines possessing a knockout mutation in the USP9X gene with/without an additional deletion of p53.Value PropositionThe cell lines present an opportunity to study the effect of loss of apoptotic control on colorectal cancer cells. Study...

Published: 9/26/2024 | Inventor(s): Dennis Harris, Fred Bunz

Keywords(s): Basic Research Biomarker, Cancer Cells, Cancers, Cell Model, Colorectal Cancer, Discovery/Research Tools, Disease Indication, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

Targeting outer nuclear membrane Bcl-2

C12294: Transgenic Bcl2 Cells and ProPSA Panel for Prostate Cancer Drug DiscoveryNovelty: Recombinant proPSA panel and transgenic Bcl2 prostate cancer cell lines, enabling the detailed mechanistic analysis of prostate tumorigenesis and development of novel anti-cancer treatment strategies.Value Proposition: Due to the lack of early clinical manifestations...

Published: 9/26/2024 | Inventor(s): Simon Williams

Keywords(s): Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Prostate Cancer, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

PIK3CA wild type and AKT1 E17K and PIK3CA H1047R knock-in MCF-7 cells

C12186: PIK3CA Wild Type and AKT1 E17K and PIK3CA H1047R Knock-in MCF-7 CellsNovelty: MCF-7 derivatives with different mutations in the phosphatidylinositol-3-kinase (PI3-kinase) pathway gene PIK3CA and AKT1.Value Proposition: MCF-7 is the most widely used human breast cancer cell line, and it serves as a valuable model for preclinical investigations...

Published: 9/26/2024 | Inventor(s): Ben Ho Park, Josh Lauring

Keywords(s): Breast Cancer, Cancer Cells, Cancers, Cell Lines, Cell Model, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Novel Human Metastatic Breast Cancer Cell Line (RBC3)

C11928: Novel Human Metastatic Breast Cancer Cell Line (RBC3) Value Proposition: Johns Hopkins researchers developed a human breast cancer cell line (RBC3) to study spinal metastasis. Specifically, the cell line was isolated from a spinal metastatic lesion, and was tagged with GFP and luciferase. When RBC3 is injected into the left ventricle of athymic...

Published: 9/26/2024 | Inventor(s): Daniel Sciubba, Mari Groves, Colette Aprhys, Rachel Sarabia-Estrada, Patricia Zadnik

Keywords(s): Breast Cancer, Cancer Cells, Cancers, Cell Lines, Cell Model, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Molecular Signatures of Invasive Cancer Subpopulations

C11851: Assay and molecular signature to identify invasive cancer cell population in tumorsNovelty: This invention is an assay for evaluating the metastatic potential of epithelial cancers, and a molecular signature linked to aggressive and invasive cancer subpopulations.Value Proposition: Inventors have developed an assay to enable stratification of...

Published: 9/26/2024 | Inventor(s): Kevin Cheung, Andrew Ewald

Keywords(s): Assay, Basic Research Biomarker, Biomarker, Cancer Cells, Cancers, Cell Model, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Mechanism-of-action Biomarker, Prognostic Biomarker, Risk Stratification, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Epithelial Cancer

BARH-like Gene 1 (BARX1) in Gastric Carcinogenesis

C11718: Novel Epigenetic Diagnostic Biomarker for Gastric CancerNovelty: A novel epigenetic biomarker for gastric cancer to enable earlier diagnosis and subsequent intervention.Value Proposition: Currently gastric cancer is diagnosed by tissue biopsies, which are invasive and can be inaccurate, often resulting in delayed diagnosis. This invention identified...

Published: 9/26/2024 | Inventor(s): Stephen Meltzer, Rachana Agarwal

Keywords(s): Biomarker, Cancer Cells, Cancers, Cell Model, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, Gastric Cancer, In Vitro Diagnostics, In Vitro Research Tool, Prognostic Biomarker, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Gastric Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Prognostic Biomarkers

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